Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rajshekhar R. Giraddi"'
Autor:
Chi-Yeh Chung, Zhibo Ma, Christopher Dravis, Sebastian Preissl, Olivier Poirion, Gidsela Luna, Xiaomeng Hou, Rajshekhar R. Giraddi, Bing Ren, Geoffrey M. Wahl
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 495-510.e6 (2019)
Summary: Technological improvements enable single-cell epigenetic analyses of organ development. We reasoned that high-resolution single-cell chromatin accessibility mapping would provide needed insight into the epigenetic reprogramming and transcrip
Externí odkaz:
https://doaj.org/article/78432d3017414d8793a92edd0f5cd258
Autor:
Rajshekhar R. Giraddi, Chi-Yeh Chung, Richard E. Heinz, Ozlen Balcioglu, Mark Novotny, Christy L. Trejo, Christopher Dravis, Berhane M. Hagos, Elnaz Mirzaei Mehrabad, Luo Wei Rodewald, Jae Y. Hwang, Cheng Fan, Roger Lasken, Katherine E. Varley, Charles M. Perou, Geoffrey M. Wahl, Benjamin T. Spike
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
Summary: The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We ad
Externí odkaz:
https://doaj.org/article/38eeb434d83440d7b7cd474042626a72
Autor:
Anna L. Means, Charles J. Cho, Dylan T. Burnette, Olivia Ben-Levy, Geoffrey M. Wahl, Rajshekhar R. Giraddi, Vincent Q. Trinh, Uri Manor, Cynthia Ramos, Abigail C. Neininger, Kathleen E. DelGiorno, Sammy Weiser Novak, Jason C. Mills, Emilee A. Patterson, Ken S. Lau, Nikki K. Lytle, Zhibo Ma, Bob Chen, Leah Caplan, Marcus Tan, James R. Goldenring, Ichiro Matsumoto, Nidhi Jyotsana, Rafael Arrojo e Drigo
Publikováno v:
Gastroenterology
BACKGROUND & AIMSAcinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies was to define the populations arising from ADM, the associated transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd3672fff60ad4a130ad5fa63b18199
https://europepmc.org/articles/PMC8792222/
https://europepmc.org/articles/PMC8792222/
Autor:
Kathleen E. DelGiorno, Sammy Weiser Novak, Dezhen Wang, Chi-Yeh Chung, Mauer Hc, Rajshekhar R. Giraddi, Linjing Fang, Geoffrey M. Wahl, Urade Y, Carolyn O’Connor, Maya Ridinger-Saison, Wahida H. Ali, Maxim N. Shokhirev, Leo Andrade, Ichiro Matsumoto, Makoto Ohmoto, Razia F. Naeem, Pankaj K. Singh, Vavinskaya, Nikki K. Lytle, Kenneth P. Olive, Gubbala Vb, Crystal Tsui, Uri Manor, Galina Erikson
Despite numerous advances in our understanding of pancreatic ductal adenocarcinoma (PDA) genetics and biology, this disease is expected to become the second leading cause of cancer-related U.S. deaths within the next few years. Incomplete understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fee87c23fa010a0ba1b6cc34ab5dc4
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2005
Cancer stem cells (CSCs) are a subpopulation of cancer cells with self-renewal capacity, that fuel tumor growth and contribute to the heterogeneous nature of tumors. First identified in hematological malignancies, CSC populations have to date been pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a75dc6c24203c2ba1de8ce95a7992d7
https://pubmed.ncbi.nlm.nih.gov/31175645
https://pubmed.ncbi.nlm.nih.gov/31175645
Autor:
Christopher Dravis, Zhibo Ma, Bing Ren, Xiaomeng Hou, Gidsela Luna, Geoffrey M. Wahl, Olivier Poirion, Sebastian Preissl, Chi-Yeh Chung, Rajshekhar R. Giraddi
SummaryIt has only recently become possible to obtain single-cell level resolution of the epigenetic changes that occur during organ development. We reasoned that precision single-cell chromatin accessibility mapping of mammary gland development coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8e5875cbb0a7a3cb23cb9e180d7e77
https://doi.org/10.1101/624957
https://doi.org/10.1101/624957
Publikováno v:
Methods in Molecular Biology ISBN: 9781493995233
Cancer stem cells (CSCs) are a subpopulation of cancer cells with self-renewal capacity, that fuel tumor growth and contribute to the heterogeneous nature of tumors. First identified in hematological malignancies, CSC populations have to date been pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eef3384c3b6fd614e15a1535939df4c
https://doi.org/10.1007/978-1-4939-9524-0_4
https://doi.org/10.1007/978-1-4939-9524-0_4
Autor:
Leonardo R. Andrade, Chi-Yeh Chung, Rajshekhar R. Giraddi, Linjing Fang, Uri Manor, H. Carlo Maurer, Dezhen Wang, Susan M. Kaech, Nasun Hah, Maxim N. Shokhirev, Zhibo Ma, Galina Erikson, Makoto Ohmoto, Carolyn O’Connor, Pankaj K. Singh, Ichiro Matsumoto, Kenneth P. Olive, Geoffrey M. Wahl, Razia F. Naeem, Crystal Tsui, Vikas B. Gubbala, Kathleen E. DelGiorno, Sammy Weiser Novak, Yoshihiro Urade, Nikki K. Lytle, Hubert Tseng, Vera Vavinskaya, Maya Ridinger-Saison, Wahida H. Ali
Publikováno v:
Gastroenterology. 159:1866-1881.e8
Background & Aims Development of pancreatic ductal adenocarcinoma (PDA) involves acinar to ductal metaplasia and genesis of tuft cells. It has been a challenge to study these rare cells because of the lack of animal models. We investigated the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee720beaeda9156dda3bc5a6451cc5cc
https://doi.org/10.1053/j.gastro.2020.07.037
https://doi.org/10.1053/j.gastro.2020.07.037
Autor:
Kathleen E, DelGiorno, Chi-Yeh, Chung, Vera, Vavinskaya, H Carlo, Maurer, Sammy Weiser, Novak, Nikki K, Lytle, Zhibo, Ma, Rajshekhar R, Giraddi, Dezhen, Wang, Linjing, Fang, Razia F, Naeem, Leonardo R, Andrade, Wahida H, Ali, Hubert, Tseng, Crystal, Tsui, Vikas B, Gubbala, Maya, Ridinger-Saison, Makoto, Ohmoto, Galina A, Erikson, Carolyn, O'Connor, Maxim Nikolaievich, Shokhirev, Nasun, Hah, Yoshihiro, Urade, Ichiro, Matsumoto, Susan M, Kaech, Pankaj K, Singh, Uri, Manor, Kenneth P, Olive, Geoffrey M, Wahl
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Development of pancreatic ductal adenocarcinoma (PDA) involves acinar to ductal metaplasia and genesis of tuft cells. It has been a challenge to study these rare cells due to lack of animal models. We investigated the role of tuft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5733792ed5f7f8b7094f281e71c177b2
https://doi.org/10.1038/s41575-020-00358-5
https://doi.org/10.1038/s41575-020-00358-5
Autor:
Christopher Dravis, Chi-Yeh Chung, Cheng Fan, Rajshekhar R. Giraddi, Mark Novotny, Benjamin T. Spike, Elnaz Mirzaei Mehrabad, Berhane M. Hagos, Ozlen Balcioglu, Roger S. Lasken, Katherine E. Varley, Richard E. Heinz, Christy L. Trejo, Luo Wei Rodewald, Charles M. Perou, Jae Y. Hwang, Geoffrey M. Wahl
Publikováno v:
Cell reports
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
Cell Reports, Vol 24, Iss 6, Pp 1653-1666.e7 (2018)
SUMMARY The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf69ec6d2a34e3038c5461594a6188d1
https://pubmed.ncbi.nlm.nih.gov/30089273
https://pubmed.ncbi.nlm.nih.gov/30089273