Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rajshekhar Alli"'
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18027 (2011)
Enhancing the affinity of therapeutic T cell receptors (TCR) without altering their specificity is a significant challenge for adoptive immunotherapy. Current efforts have primarily relied on empirical approaches. Here, we used structural analyses to
Externí odkaz:
https://doaj.org/article/efb41d259f3f4f2a84d555222be9ea0f
Autor:
Terrence L. Geiger, Hossam A. Abdelsamed, Ben Youngblood, Rajshekhar Alli, Carol E. O’Hear, Jacob Halum Basham, Wenting Zheng, Lance E. Palmer, Lindsay L. Jones
Publikováno v:
Leukemia. 32:1157-1167
In vivo persistence of chimeric antigen receptor (CAR)-modified T cells correlates with therapeutic efficacy, yet CAR-specific factors that support persistence are not well resolved. Using a CD33-specific CAR in an acute myeloid leukemia (AML) model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa10d9770eb0ca375d0915d8fd302e66
https://doi.org/10.1038/s41375-017-0008-6
https://doi.org/10.1038/s41375-017-0008-6
Publikováno v:
The Journal of Immunology. 196:2973-2985
How a large number of cytokines differentially signal through a small number of signal transduction pathways is not well resolved. This is particularly true for IL-6 and IL-10, which act primarily through STAT3 yet induce dissimilar transcriptional p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a35aec07f64a67c0290fc56e5428ee
https://doi.org/10.4049/jimmunol.1402953
https://doi.org/10.4049/jimmunol.1402953
Publikováno v:
Mucosal immunology
Breakdown of the epithelial barrier because of toxins or other insults leads to severe colitis. Interleukin-10 (IL-10) is a critical regulator of this, yet its cellular targets and mechanisms of action are not resolved. We address this here. Mice wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40582afb6e8d751f068ca67d20aae775
http://europepmc.org/articles/PMC4045662
http://europepmc.org/articles/PMC4045662
Publikováno v:
The Journal of Immunology. 189:669-678
IL-10 is a critical anti-inflammatory cytokine, the deficiency of which leads to spontaneous autoimmunity. However, therapeutically administered or ectopically expressed IL-10 can either suppress or promote disease. Distinct lineage-specific activiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f43f170e005e6984484c1562ae6a457
https://doi.org/10.4049/jimmunol.1200607
https://doi.org/10.4049/jimmunol.1200607
Publikováno v:
The Journal of Immunology. 182:4439-4447
We describe a simple iterative approach to augment TCR affinity, which we studied using a myelin oligodendrocyte glycoprotein-specific TCR. We hypothesized that single amino acid modifications in TCR CDR3 could enhance TCR sensitivity through focal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121b1399295fb262c75be1110f5948c6
https://doi.org/10.4049/jimmunol.0804377
https://doi.org/10.4049/jimmunol.0804377
Publikováno v:
The Journal of Immunology. 174:3789-3797
We previously showed that transgenically expressed chimeric Ag-MHC-ζ receptors can Ag-specifically redirect T cells against other T cells. When the receptor’s extracellular Ag-MHC domain engages cognate TCR on an Ag-specific T cell, its cytoplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c344457d4826023b574186fde397b9e6
https://doi.org/10.4049/jimmunol.174.6.3789
https://doi.org/10.4049/jimmunol.174.6.3789
Publikováno v:
The Journal of Immunology. 197:674-675
How a large number of cytokines differentially signal through a small number of signal transduction pathways is not well resolved. This is particularly true for IL-6 and IL-10, which act primarily through STAT3 yet induce dissimilar transcriptional p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f3e0d4be992823c9f5816fbc3a95c8
https://doi.org/10.4049/jimmunol.1600853
https://doi.org/10.4049/jimmunol.1600853
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(11)
Whereas increased affinity enhances T cell competitiveness after immunization, the role of affinity in modulating the pathogenicity of self-reactive T cells is less established. To assess this, we generated two myelin-specific, class II MHC-restricte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40014fc0bfc883438f1aff44cf1e9a4
https://pubmed.ncbi.nlm.nih.gov/22025553
https://pubmed.ncbi.nlm.nih.gov/22025553
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18027 (2011)
PLoS ONE
PloS one, vol 6, iss 3
PLoS ONE
PloS one, vol 6, iss 3
Enhancing the affinity of therapeutic T cell receptors (TCR) without altering their specificity is a significant challenge for adoptive immunotherapy. Current efforts have primarily relied on empirical approaches. Here, we used structural analyses to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cc157683db409e3c6848a99a6054af
http://europepmc.org/articles/PMC3063236?pdf=render
http://europepmc.org/articles/PMC3063236?pdf=render