Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rajnikanth Madabushi"'
Publikováno v:
Clinical Pharmacology and Therapeutics
Liver plays a major role in drug metabolism and is one of the main sites of drug adverse effects. Microphysiological systems (MPS), also known as organs-on-a-chip, are a class of microfluidic platforms that recreate properties of tissue microenvironm
Autor:
Richard B. Horenstein, Laura M. Yerges-Armstrong, Issam Zineh, Michael Pacanowski, Robert N. Schuck, Rajnikanth Madabushi, Alan R. Shuldiner, William D. Figg, Cody J. Peer
Publikováno v:
The Journal of Clinical Pharmacology. 54:865-873
Carriers of two copies of the loss-of-function CYP2C19*2 variant convert less clopidogrel into its active metabolite, resulting in diminished antiplatelet responses and higher cardiovascular event rates. To evaluate whether increasing the daily clopi
Autor:
Shiew-Mei Huang, Michael F. Flessner, Prabir Roy-Chaudhury, John K. Leypoldt, Rajnikanth Madabushi, Kellie S. Reynolds, Thomas D. Nolin, Jennifer W. Witcher, William H. Fissell, Lokesh Jain, Patrick Archdeacon, Lei Zhang, George R. Aronoff, Issam Zineh, Rajnish Mehrotra, Stuart L. Goldstein
Publikováno v:
Clinical journal of the American Society of Nephrology : CJASN. 10(1)
The effect of AKI and modern continuous RRT (CRRT) methods on drug disposition (pharmacokinetics) and response has been poorly studied. Pharmaceutical manufacturers have little incentive to perform pharmacokinetic studies in patients undergoing CRRT
Autor:
Pravin R. Jadhav, Lawrence J. Lesko, Fang Li, Christine Garnett, Jogarao V. S. Gobburu, Anshu Marathe, Yaning Wang, Rajnikanth Madabushi, Christoffer W. Tornøe, Hao Zhu, Venkatesh A. Bhattaram, Joo Yeon Lee, Jiang Liu, Satjit Brar, Nitin Mehrotra, Kevin Krudys, Justin C. Earp
Publikováno v:
Clinical pharmacokinetics. 50(10)
Pharmacometric analyses have become an increasingly important component of New Drug Application (NDA) and Biological License Application (BLA) submissions to the US FDA to support drug approval, labelling and trial design decisions. Pharmacometrics i
Autor:
Lawrence J. Lesko, W Hao, Jogarao V. S. Gobburu, Ramana S. Uppoor, Bei Yu, Robert Temple, Mehul Mehta, Rajnikanth Madabushi, V A Bhattaram, D Menon-Andersen, Thomas Laughren, Norman Stockbridge
Publikováno v:
Clinical pharmacology and therapeutics. 90(3)
A critical issue in labeling is to succinctly communicate, in a manner that is readily understandable and actionable, changes in systemic exposure that affect drug dosing. Current practices in labeling make it difficult for prescribers to locate the
Autor:
T. C. Wu, Nam Atiqur Rahman, S. S. Brar, Lei Zhang, Lawrence J. Lesko, Rajnikanth Madabushi, Qi Liu, P. Song, Y. J. Moon, Brian Booth, Joseph A. Grillo, Huang Sm, E Gil Berglund, Kellie S. Reynolds, Ping Zhao, Julie Bullock
Publikováno v:
Clinical pharmacology and therapeutics. 89(2)
Physiologically based pharmacokinetic (PBPK) modeling and simulation is a tool that can help predict the pharmacokinetics of drugs in humans and evaluate the effects of intrinsic (e.g., organ dysfunction, age, genetics) and extrinsic (e.g., drug-drug
Autor:
R P Ramchandani, Christine Garnett, Rajnikanth Madabushi, J Z Duan, J R Powell, D M Chilukuri, Lawrence J. Lesko, Y Men, Jogarao V. S. Gobburu, L. Kenna, Seong H. Jang, V A Bhattaram, C W Tornoe, Jenny J. Zheng, C Bonapace, Yow-Ming C Wang, Wei Qiu
Publikováno v:
Clinical pharmacology and therapeutics. 81(2)
Exploratory analyses of data pertaining to pharmacokinetic, pharmacodynamic, and disease progression are often referred to as the pharmacometrics (PM) analyses. The objective of the current report is to assess the role of PM, at the Food and Drug Adm
Autor:
Zineh, Issam1 Issam.zineh@fda.hhs.gov
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. Jun2019, Vol. 8 Issue 6, p336-339. 4p.
Autor:
Mehrotra, S1, Gobburu, J1
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. Apr2016, Vol. 5 Issue 4, p163-172. 10p.
Autor:
Mehrotra, Nitin nitin.mehrotra@fda.hhs.gov, Yaning Wang, Bhattaram, Venkatesh A., Earp, Justin C., Florian, Jeffry, Garnett, Christine, Jadhav, Pravin R., Krudys, Kevin, Joo-Yeon Lee, Fang Li, Jiang Liu, Madabushi, Rajnikanth, Marathe, Anshu, Tornoe, Christoffer W., Hao Zhu, Gobburu, Jogarao V.
Publikováno v:
Applied Clinical Trials. Feb2012, Vol. 21 Issue 2, p40-52. 9p.