Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Rajni Sonavane"'
Autor:
Anindita Ravindran, Kimiko L. Krieger, Akash K. Kaushik, Hélène Hovington, Sadia Mehdi, Danthasinghe Waduge Badrajee Piyarathna, Vasanta Putluri, Paul Basil, Uttam Rasaily, Franklin Gu, Truong Dang, Jong Min Choi, Rajni Sonavane, Sung Yun Jung, Lisha Wang, Rohit Mehra, Nancy L. Weigel, Nagireddy Putluri, David R. Rowley, Ganesh S. Palapattu, Chantal Guillemette, Louis Lacombe, Éric Lévesque, Arun Sreekumar
Publikováno v:
Cells, Vol 11, Iss 15, p 2329 (2022)
Prostate cancer (PCa) is the second most diagnosed cancer in the United States and is associated with metabolic reprogramming and significant disparities in clinical outcomes among African American (AA) men. While the cause is likely multi-factorial,
Externí odkaz:
https://doaj.org/article/21fa31e76e474fb6b719fbe7d3615cfd
Autor:
Collin Gilbreath, Shihong Ma, Lan Yu, Rajni Sonavane, Carlos M. Roggero, Anvita Devineni, Ryan Mauck, Neil B. Desai, Aditya Bagrodia, Ralf Kittler, Ganesh V. Raj, Yi Yin
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100898- (2021)
The study of DNA damage repair response (DDR) in prostate cancer is restricted by the limited number of prostate cancer cell lines and lack of surrogates for heterogeneity in clinical samples. Here, we sought to leverage our experience with patient d
Externí odkaz:
https://doaj.org/article/81556393fb8f47888a4c4ffdabdcfa43
Autor:
Akash K. Kaushik, Ali Shojaie, Katrin Panzitt, Rajni Sonavane, Harene Venghatakrishnan, Mohan Manikkam, Alexander Zaslavsky, Vasanta Putluri, Vihas T. Vasu, Yiqing Zhang, Ayesha S. Khan, Stacy Lloyd, Adam T. Szafran, Subhamoy Dasgupta, David A. Bader, Fabio Stossi, Hangwen Li, Susmita Samanta, Xuhong Cao, Efrosini Tsouko, Shixia Huang, Daniel E. Frigo, Lawrence Chan, Dean P. Edwards, Benny A. Kaipparettu, Nicholas Mitsiades, Nancy L. Weigel, Michael Mancini, Sean E. McGuire, Rohit Mehra, Michael M. Ittmann, Arul M. Chinnaiyan, Nagireddy Putluri, Ganesh S. Palapattu, George Michailidis, Arun Sreekumar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The molecular alterations driving anti-androgen resistance in prostate cancer are unclear. Here, the authors show, using a network-based approach, that inhibition of the hexosamine biosynthetic pathway is necessary to develop resistance and that incr
Externí odkaz:
https://doaj.org/article/928bd0a4d45444ac89e49f796339b9e4
Publikováno v:
Molecules, Vol 24, Iss 15, p 2783 (2019)
The interaction between androgen receptor (AR) and coactivator proteins plays a critical role in AR-mediated prostate cancer (PCa) cell growth, thus its inhibition is emerging as a promising strategy for PCa treatment. To develop potent inhibitors of
Externí odkaz:
https://doaj.org/article/c1b694cac2184868a7059426aa433db4
Autor:
Ratna K. Vadlamudi, Klaus J. Nickisch, Hareesh B. Nair, Rajeshwar R. Tekmal, Manjeet K. Rao, Vijaya Manthati, Andrew J. Brenner, Ganesh V. Raj, Marek Bajda, Ramachandran Murali, Xinlei Pan, Kam Y.J. Zhang, Kalarickal V. Dileep, Alejandra Chávez-Riveros, Annabel Chang, Xiaonan Li, Kristin A. Altwegg, Uday P. Pratap, Rajni Sonavane, Shihong Ma, Mengxing Li, Mei Zhou, Bindu Santhamma, Gangadhara R. Sareddy, Yiliao Luo, Suryavathi Viswanadhapalli
Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer progression, metastasis, stem cell maintenance, and therapy resistance. Here, we describe a rationally designed first-in-class inhibitor of LIFR, EC359, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07cd43c1488eac97dde539175fac68e
https://doi.org/10.1158/1535-7163.c.6538359.v1
https://doi.org/10.1158/1535-7163.c.6538359.v1
Autor:
Ratna K. Vadlamudi, Klaus J. Nickisch, Hareesh B. Nair, Rajeshwar R. Tekmal, Manjeet K. Rao, Vijaya Manthati, Andrew J. Brenner, Ganesh V. Raj, Marek Bajda, Ramachandran Murali, Xinlei Pan, Kam Y.J. Zhang, Kalarickal V. Dileep, Alejandra Chávez-Riveros, Annabel Chang, Xiaonan Li, Kristin A. Altwegg, Uday P. Pratap, Rajni Sonavane, Shihong Ma, Mengxing Li, Mei Zhou, Bindu Santhamma, Gangadhara R. Sareddy, Yiliao Luo, Suryavathi Viswanadhapalli
Supplementary Figure S1 shows SPR studies and Biotin EC359 pull down assays; Supplementary Figure S2 shows superimposition of hLIFR onto the mLIFR -hLIF complex; Supplementary Figure S3 shows sequence alignment of human (P42702) and mouse (P42703) LI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ee451be075a9d46cb02b1970ab4b84
https://doi.org/10.1158/1535-7163.22506315
https://doi.org/10.1158/1535-7163.22506315
Autor:
Ratna K. Vadlamudi, Klaus J. Nickisch, Hareesh B. Nair, Rajeshwar R. Tekmal, Manjeet K. Rao, Vijaya Manthati, Andrew J. Brenner, Ganesh V. Raj, Marek Bajda, Ramachandran Murali, Xinlei Pan, Kam Y.J. Zhang, Kalarickal V. Dileep, Alejandra Chávez-Riveros, Annabel Chang, Xiaonan Li, Kristin A. Altwegg, Uday P. Pratap, Rajni Sonavane, Shihong Ma, Mengxing Li, Mei Zhou, Bindu Santhamma, Gangadhara R. Sareddy, Yiliao Luo, Suryavathi Viswanadhapalli
Supplementary methods section contain description of synthesis and characterization of EC330 and EC359, SPR studies, structural and sequence comparison of human and mouse LIFR, energy minimization of hLIFR, Protein and ligand preparation, molecular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f80ccb9927594621014305b0b7429d
https://doi.org/10.1158/1535-7163.22506309.v1
https://doi.org/10.1158/1535-7163.22506309.v1
Autor:
Suryavathi Viswanadhapalli, Marek Bajda, Kam Y. J. Zhang, Ramachandran Murali, Manjeet K. Rao, Klaus J. Nickisch, Mengxing Li, Xiaonan Li, Ganesh V. Raj, Annabel Chang, Ratna K. Vadlamudi, Kalarickal V. Dileep, Shihong Ma, Kristin A. Altwegg, Rajni Sonavane, Vijaya Manthati, Mei Zhou, Yiliao Luo, Hareesh B. Nair, Xinlei Pan, Rajeshwar Rao Tekmal, Uday P. Pratap, Andrew Brenner, Alejandra Chavez-Riveros, Bindu Santhamma, Gangadhara R. Sareddy
Publikováno v:
Mol Cancer Ther
Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer progression, metastasis, stem cell maintenance, and therapy resistance. Here, we describe a rationally designed first-in-class inhibitor of LIFR, EC359, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c685d6bfed97cbde41d578e7a1ee80
https://doi.org/10.1158/1535-7163.mct-18-1258
https://doi.org/10.1158/1535-7163.mct-18-1258
Autor:
Andrew Dang, Rey-Chen Pong, Rajni Sonavane, Ho Lin, Shihong Ma, Arnaldo A. Arbini, Shu-Fen Tseng, Elizabeth Hernandez, John Santoyo, Jer Tsong Hsieh, Ganesh V. Raj, Payal Kapur, Leah Gandee, U-Ging Lo, Loredana Moro, Diane Yang, Jun Huang, Chih Ho Lai, Dalin He, Chung Jung Lin
Publikováno v:
Cancer Research. 79:1098-1112
IFNγ, a potent cytokine known to modulate tumor immunity and tumoricidal effects, is highly elevated in patients with prostate cancer after radiation. In this study, we demonstrate that IFNγ can induce epithelial-to-mesenchymal transition (EMT) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3cfee313f0b7dc22f53fbe8a824f90
https://doi.org/10.1158/0008-5472.can-18-2207
https://doi.org/10.1158/0008-5472.can-18-2207
Autor:
Rajni Sonavane, Ganesh V. Raj, Aditya Bagrodia, Anvita Devineni, Ralf Kittler, Yi Yin, Lan Yu, Collin Gilbreath, Carlos M. Roggero, Shihong Ma, Neil Desai, Ryan Mauck
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100898-(2021)
Translational Oncology
Translational Oncology
The study of DNA damage repair response (DDR) in prostate cancer is restricted by the limited number of prostate cancer cell lines and lack of surrogates for heterogeneity in clinical samples. Here, we sought to leverage our experience with patient d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1164d4d83ffc7f1b2c90713b27a88d
http://www.sciencedirect.com/science/article/pii/S1936523320303909
http://www.sciencedirect.com/science/article/pii/S1936523320303909