Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rajni K. Wilson"'
Autor:
Danyon O. Graham, Rajni K. Wilson, Yasmeen N. Ruma, Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk
Publikováno v:
Journal of Fungi, Vol 7, Iss 11, p 897 (2021)
Target-based azole resistance in Candida albicans involves overexpression of the ERG11 gene encoding lanosterol 14α-demethylase (LDM), and/or the presence of single or multiple mutations in this enzyme. Overexpression of Candida albicans LDM (CaLDM)
Externí odkaz:
https://doaj.org/article/2fb14a794e4d4733aafc6a6df72d6c0b
Autor:
A. Vikas Aggarwal, Scott A. Cameron, Stuart J. Malthus, Sally Brooker, David S. Larsen, Rajni K. Wilson
Publikováno v:
Dalton Transactions. 46:3141-3149
The very different multi-step routes to the closely related pair of diformyl-carbazole head units, 1,8-diformyl-3,6-di-tert-butyl-9H-carbazole (1tBu) and 1,8-diformyl-9H-carbazole (1H), are detailed and compared. The first examples of Schiff base mac
Autor:
Mikhail V. Keniya, Harith F. Hassan, Rajni K. Wilson, Brian C. Monk, Danyon O. Graham, Manya Sabherwal, Joel D. A. Tyndall, Danni Chen
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Tetrazole antifungals designed to target fungal lanosterol 14α-demethylase (LDM) appear to be effective against a range of fungal pathogens. In addition, a crystal structure of the catalytic domain of Candida albicans LDM in complex with the tetrazo
Publikováno v:
Supramolecular Chemistry. 28:98-107
The synthesis and characterisation of two cobalt(II) complexes, [CoIILBr-acrCl2] (1a) and [CoIILH-acrCl2] (1b), with acridine head-units resulting from an unexpected ligand rearrangement from a diphenylamine head-unit, and the intended cobalt(II) com
Autor:
Mikhail V. Keniya, Brian C. Monk, Manya Sabherwal, Joel D. A. Tyndall, Rajni K. Wilson, Alia A. Sagatova, Matthew A. Woods
Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are not optimal for immunocompromised patients and individuals with comorbidities. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ffb49ea97e4543c1a09084e4be2874
https://europepmc.org/articles/PMC6201081/
https://europepmc.org/articles/PMC6201081/
Autor:
Rajni K. Wilson, Parham Hosseini, Mikhail V. Keniya, Brian C. Monk, Alia A. Sagatova, Yasmeen N. Ruma
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1868(3)
The cytochrome P450 enzyme lanosterol 14α-demethylase (LDM) is the target of the azole antifungals used widely in medicine and agriculture as prophylaxis or treatments of infections or diseases caused by fungal pathogens. These drugs and agrochemica
Autor:
Stuart J, Malthus, Rajni K, Wilson, A, Vikas Aggarwal, Scott A, Cameron, David S, Larsen, Sally, Brooker
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 46(10)
The very different multi-step routes to the closely related pair of diformyl-carbazole head units, 1,8-diformyl-3,6-di-tert-butyl-9H-carbazole (1tBu) and 1,8-diformyl-9H-carbazole (1H), are detailed and compared. The first examples of Schiff base mac
Publikováno v:
Australian Journal of Chemistry. 72:805
Three manganese macrocyclic complexes of two anionic N4-donor [1+1] Schiff-base macrocycles that differ in ring size (14 versus 16 membered), HLEt and HLPr (obtained from condensation of diphenylamine-2,2′-dicarboxaldehyde and either diethylenetria
Autor:
Brian C. Monk, Manya Sabherwal, Rajni K. Wilson, Joel D. A. Tyndall, Mikhail V. Keniya, Alia A. Sagatova
Publikováno v:
Scientific Reports
Emergence of fungal strains showing resistance to triazole drugs can make treatment of fungal disease problematic. Triazole resistance can arise due to single mutations in the drug target lanosterol 14α-demethylase (Erg11p/CYP51). We have determined
Autor:
Matthew A. Woods, Klaus Tietjen, Mikhail V. Keniya, Jacopo Negroni, Brian C. Monk, Manya Sabherwal, Joel D. A. Tyndall, Alia A. Sagatova, Rajni K. Wilson
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167485 (2016)
PLoS ONE
PLoS ONE
Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14α-demethylase (CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of both plants and humans. DMIs remain the treatment of choice in crop protection against a w