Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Rajmohan Murali"'
Autor:
Lea A. Moukarzel, Lorenzo Ferrando, Arnaud Da Cruz Paula, David N. Brown, Felipe C. Geyer, Fresia Pareja, Salvatore Piscuoglio, Anastasios D. Papanastasiou, Nicola Fusco, Caterina Marchiò, Nadeem R. Abu‐Rustum, Rajmohan Murali, Edi Brogi, Hannah Y. Wen, Larry Norton, Robert A. Soslow, Anne Vincent‐Salomon, Jorge S. Reis‐Filho, Britta Weigelt
Publikováno v:
Molecular Oncology, Vol 15, Iss 4, Pp 1024-1039 (2021)
Metaplastic breast carcinoma (MBC) and uterine carcinosarcoma (UCS) are rare aggressive cancers, characterized by an admixture of adenocarcinoma and areas displaying mesenchymal/sarcomatoid differentiation. We sought to define whether MBCs and UCSs h
Externí odkaz:
https://doaj.org/article/d43d7492291245088deab363a8092b63
Autor:
Amanda R. Moore, Leili Ran, Youxin Guan, Jessica J. Sher, Tyler D. Hitchman, Jenny Q. Zhang, Catalina Hwang, Edward G. Walzak, Alexander N. Shoushtari, Sébastien Monette, Rajmohan Murali, Thomas Wiesner, Klaus G. Griewank, Ping Chi, Yu Chen
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2455-2468 (2018)
Summary: Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We gene
Externí odkaz:
https://doaj.org/article/f955f766b62846e19190082e6000d91d
Autor:
Haley Hieronymus, Phillip J. Iaquinta, John Wongvipat, Anuradha Gopalan, Rajmohan Murali, Ninghui Mao, Brett S. Carver, Charles L. Sawyers
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Although the locus at 3p13-14 is commonly deleted in prostate cancer, the identity of the potential driver genes is still unclear. Here, the authors, using a PTEN loss-driven prostate cancer mouse model, show that a multigenic FOXP1-SHQ1 deletion is
Externí odkaz:
https://doaj.org/article/836ceacd80084e6394c47fe1007f64e2
Autor:
Haley Hieronymus, Rajmohan Murali, Amy Tin, Kamlesh Yadav, Wassim Abida, Henrik Moller, Daniel Berney, Howard Scher, Brett Carver, Peter Scardino, Nikolaus Schultz, Barry Taylor, Andrew Vickers, Jack Cuzick, Charles L Sawyers
Publikováno v:
eLife, Vol 7 (2018)
The level of copy number alteration (CNA), termed CNA burden, in the tumor genome is associated with recurrence of primary prostate cancer. Whether CNA burden is associated with prostate cancer survival or outcomes in other cancers is unknown. We ana
Externí odkaz:
https://doaj.org/article/9bb98e789ff74231b7de3a9771793c64
Autor:
Sohela Shah, Yonghwan Kim, Irina Ostrovnaya, Rajmohan Murali, Kasmintan A Schrader, Francis P Lach, Kara Sarrel, Rohini Rau-Murthy, Nichole Hansen, Liyng Zhang, Tomas Kirchhoff, Zsofia Stadler, Mark Robson, Joseph Vijai, Kenneth Offit, Agata Smogorzewska
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66961 (2013)
BACKGROUNDSLX4 encodes a DNA repair protein that regulates three structure-specific endonucleases and is necessary for resistance to DNA crosslinking agents, topoisomerase I and poly (ADP-ribose) polymerase (PARP) inhibitors. Recent studies have repo
Externí odkaz:
https://doaj.org/article/6f206f916a4c42f58d026f6cb76adda8
Autor:
Klaus G Griewank, Rajmohan Murali, Bastian Schilling, Tobias Schimming, Inga Möller, Iris Moll, Marion Schwamborn, Antje Sucker, Lisa Zimmer, Dirk Schadendorf, Uwe Hillen
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80354 (2013)
Activating mutations in the TERT promoter were recently identified in up to 71% of cutaneous melanoma. Subsequent studies found TERT promoter mutations in a wide array of other major human cancers. TERT promoter mutations lead to increased expression
Externí odkaz:
https://doaj.org/article/4bbf46dbbbd44de1abdea268573cdfd7
Autor:
Amir Momeni-Boroujeni, Chad Vanderbilt, Elham Yousefi, Nadeem R. Abu-Rustum, Carol Aghajanian, Robert A. Soslow, Lora H. Ellenson, Britta Weigelt, Rajmohan Murali
Publikováno v:
Gynecologic Oncology. 172:54-64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ef4464e93ed56747bcd9783eb1a7c44
https://doi.org/10.1016/j.ygyno.2023.03.010
https://doi.org/10.1016/j.ygyno.2023.03.010
Publikováno v:
Cancer Cytopathology. 131:254-261
In this study, the authors sought to describe the cytologic features of primary gynecologic germ cell tumors and carcinomas exhibiting germ cell differentiation because little information currently exists.An institutional database search was performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c2345e1139b4161fc4509daa5e86d0
https://doi.org/10.1002/cncy.22673
https://doi.org/10.1002/cncy.22673
Autor:
Anne Zaremba, Philipp Jansen, Rajmohan Murali, Anand Mayakonda, Anna Riedel, Manuel Philip, Christian Rose, Jörg Schaller, Hansgeorg Müller, Heinz Kutzner, Inga Möller, Nadine Stadtler, Julia Kretz, Antje Sucker, Agnes Bankfalvi, Elisabeth Livingstone, Lisa Zimmer, Susanne Horn, Annette Paschen, Christoph Plass, Dirk Schadendorf, Eva Hadaschik, Pavlo Lutsik, Klaus Griewank
Publikováno v:
International Journal of Cancer. 151:1542-1554
in press Accurate classification of melanocytic tumors is important for prognostic evaluation, treatment and follow-up protocols of patients. The majority of melanocytic proliferations can be classified solely based on clinical and pathological crite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e4a01f5cb504d29049ec8be3718523
https://doi.org/10.1002/ijc.34187
https://doi.org/10.1002/ijc.34187
Autor:
Siyu Sun, Jungeui Hong, Eunae You, Kaloyan M. Tsanov, Jonathan Chacon-Barahona, Andrea Di Gioacchino, David Hoyos, Hao Li, Hua Jiang, Han Ly, Sajid Marhon, Rajmohan Murali, Pharto Chanda, Ali Karacay, Nicolas Vabret, Daniel D. De Carvalho, John LaCava, Scott W. Lowe, David T. Ting, Christine A. Iacobuzio-Donahue, Alexander Solovyov, Benjamin D. Greenbaum
Publikováno v:
bioRxiv
Overexpression of repetitive elements is an emerging hallmark of human cancers1. Diverse repeats can mimic viruses by replicating within the cancer genome through retrotransposition, or presenting pathogen-associated molecular patterns (PAMPs) to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd5f8b2946191e39fbe429d21208a19
https://doi.org/10.1101/2023.05.19.541456
https://doi.org/10.1101/2023.05.19.541456
