Salmonella Typhimurium employs spermidine to exert protection against ROS-mediated cytotoxicity and rewires host polyamine metabolism to ameliorate its survival in macrophages.

Autor: Nair AV; Department of Microbiology and Cell Biology, Division of Biological Sciences, Indian Institute of Science, Bengaluru, India., Singh A; Department of Microbiology and Cell Biology, Division of Biological Sciences, Indian Institute of Science, Bengaluru, India., Rajmani RS; Molecular Biophysics Unit, Indian Institute of Science, Bengaluru, India., Chakravortty D; Department of Microbiology and Cell Biology, Division of Biological Sciences, Indian Institute of Science, Bengaluru, India; Adjunct Faculty, School of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram, India. Electronic address: dipa@iisc.ac.in.

Publikováno v: Redox biology [Redox Biol] 2024 Jun; Vol. 72, pp. 103151. Date of Electronic Publication: 2024 Apr 03.

MicroRNA-22-3p displaces critical host factors from the 5' UTR and inhibits the translation of Coxsackievirus B3 RNA.

Autor: Rani P; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India., George B; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India., V S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India., Biswas S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India., V M; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India., Pal A; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India., Rajmani RS; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India., Das S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.; National Institute of Biomedical Genomics, Kalyani, India.

Publikováno v: Journal of virology [J Virol] 2024 Feb 20; Vol. 98 (2), pp. e0150423. Date of Electronic Publication: 2024 Jan 30.

Cysteine desulfurase (IscS)-mediated fine-tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis hypervirulence.

Autor: Das M; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012, India., Sreedharan S; Institute for Stem Cell Science and Regenerative Medicine, Bangalore 560065, India.; School of Chemical and Biotechnology, (SASTRA)-Deemed to be University, Thanjavur 613401, India., Shee S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012, India., Malhotra N; National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065, India., Nandy M; National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065, India., Banerjee U; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India., Kohli S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012, India., Rajmani RS; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India., Chandra N; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India., Seshasayee ASN; National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR), Bangalore 560065, India., Laxman S; Institute for Stem Cell Science and Regenerative Medicine, Bangalore 560065, India., Singh A; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.; Centre for Infectious Disease Research, Indian Institute of Science, Bangalore 560012, India.

Publikováno v: Science advances [Sci Adv] 2023 Dec 15; Vol. 9 (50), pp. eadh2858. Date of Electronic Publication: 2023 Dec 13.

Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants.

Autor: Mittal N; Molecular Biophysics Unit (MBU), Indian Institute of Science, Bengaluru, 560012, India., Kumar S; Virology Unit, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Chandigarh, 160036, India., Rajmani RS; Molecular Biophysics Unit (MBU), Indian Institute of Science, Bengaluru, 560012, India., Singh R; Mynvax Private Limited; 3rd Floor, Brigade MLR Centre, No.50, Vani Vilas Road, Basavanagudi, Bengaluru, 560004, India., Lemoine C; Vaccine Formulation Institute; Rue du Champ-Blanchod 4, 1228, Plan-les-Ouates, Switzerland., Jakob V; Vaccine Formulation Institute; Rue du Champ-Blanchod 4, 1228, Plan-les-Ouates, Switzerland., Bj S; Mynvax Private Limited; 3rd Floor, Brigade MLR Centre, No.50, Vani Vilas Road, Basavanagudi, Bengaluru, 560004, India., Jagannath N; Mynvax Private Limited; 3rd Floor, Brigade MLR Centre, No.50, Vani Vilas Road, Basavanagudi, Bengaluru, 560004, India., Bhat M; Mynvax Private Limited; 3rd Floor, Brigade MLR Centre, No.50, Vani Vilas Road, Basavanagudi, Bengaluru, 560004, India., Chakraborty D; Molecular Biophysics Unit (MBU), Indian Institute of Science, Bengaluru, 560012, India., Pandey S; Mynvax Private Limited; 3rd Floor, Brigade MLR Centre, No.50, Vani Vilas Road, Basavanagudi, Bengaluru, 560004, India., Jory A; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru, 560065, India., Sa SS; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru, 560065, India., Kleanthous H; Bill and Melinda Gates Foundation, Seattle, WA, 98109, USA., Dubois P; Vaccine Formulation Institute; Rue du Champ-Blanchod 4, 1228, Plan-les-Ouates, Switzerland., Ringe RP; Virology Unit, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Chandigarh, 160036, India. rajeshringe@imtech.res.in., Varadarajan R; Molecular Biophysics Unit (MBU), Indian Institute of Science, Bengaluru, 560012, India. varadar@iisc.ac.in.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2023 Oct 25; Vol. 8 (1), pp. 161. Date of Electronic Publication: 2023 Oct 25.

PARP1 inhibition protects mice against Japanese encephalitis virus infection.

Autor: Desingu PA; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India. Electronic address: padesingu@gmail.com., Mishra S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India., Dindi L; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India., Srinivasan S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India., Rajmani RS; Centre for Infectious Disease Research, Indian Institute of Science, Bengaluru 560012, India., Ravi V; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India., Tamta AK; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India., Raghu S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India., Murugasamy K; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India., Pandit AS; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India., Sundaresan NR; Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India. Electronic address: rsundaresan@iisc.ac.in.

Publikováno v: Cell reports [Cell Rep] 2023 Sep 26; Vol. 42 (9), pp. 113103. Date of Electronic Publication: 2023 Sep 06.