Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Rajkumar Venkatadri"'
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Lupus glomerulonephritis (LN) is a complex autoimmune disease characterized by circulating autoantibodies, immune-complex deposition, immune dysregulation and defects in regulatory T cell (Tregs). Treatment options rely on general immunosuppressants
Externí odkaz:
https://doaj.org/article/178700c6f70e45ee9843b13b460bef18
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Acute kidney injury (AKI) is a major clinical burden affecting 20 to 50% of hospitalized and intensive care patients. Irrespective of the initiating factors, the immune system plays a major role in amplifying the disease pathogenesis with certain imm
Externí odkaz:
https://doaj.org/article/0ef0f9aa56b04057afcb07e7803f879e
Autor:
Yogesh M Kulkarni, Juan S Yakisich, Neelam Azad, Rajkumar Venkatadri, Vivek Kaushik, George O’Doherty, Anand Krishnan V Iyer
Publikováno v:
Tumor Biology, Vol 39 (2017)
While there are targeted treatments for triple positive breast cancers, lack of specific biomarkers for triple-negative breast cancers (TNBC) has hindered the development of therapies for this subset of cancers. In this study, we evaluated the antica
Externí odkaz:
https://doaj.org/article/0c88611a59574dba8519e7240098b132
Autor:
Rupkatha Mukhopadhyay, Sujayita Roy, Rajkumar Venkatadri, Yu-Pin Su, Wenjuan Ye, Elena Barnaeva, Lesley Mathews Griner, Noel Southall, Xin Hu, Amy Q Wang, Xin Xu, Andrés E Dulcey, Juan J Marugan, Marc Ferrer, Ravit Arav-Boger
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005717 (2016)
Infection with human cytomegalovirus (HCMV) is a threat for pregnant women and immunocompromised hosts. Although limited drugs are available, development of new agents against HCMV is desired. Through screening of the LOPAC library, we identified eme
Externí odkaz:
https://doaj.org/article/b0195ea1eaba4caab9efda2a3f291a03
Autor:
Juan Sebastian Yakisich, Neelam Azad, Rajkumar Venkatadri, Yogesh Kulkarni, Clayton Wright, Vivek Kaushik, Anand Krishnan V. Iyer
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Like with most solid tumors, the presence of a subpopulation of cancer stem cells (CSCs) or cancer stem-like cells (CS-LCs) has been associated with chemoresistance and tumor relapse in lung cancer cells. In the absence of serum, CSCs/CS-LCs have the
Externí odkaz:
https://doaj.org/article/b443c3d6eefd453da896d3d0750ae297
Autor:
Rajkumar Venkatadri, Vikram Sabapathy, Murat Dogan, Saleh Mohammad, Scott E. Harvey, Sean R. Simpson, Jason M. Grayson, Nan Yan, Fred W. Perrino, Rahul Sharma
Publikováno v:
European journal of immunology. 52(5)
The Three Prime Repair EXonuclease I (TREX1) is critical for degrading post-apoptosis DNA. Mice expressing catalytically inactive TREX1 (TREX1 D18N) develop lupus-like autoimmunity due to chronic sensing of undegraded TREX1 DNA substrates, production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f060d87aded2057f431066a87d29777a
https://pubmed.ncbi.nlm.nih.gov/35112355
https://pubmed.ncbi.nlm.nih.gov/35112355
Autor:
Ananda Basu, Vikram Sabapathy, Rajia Arbab, Rahul Sharma, Murat Dogan, Rajkumar Venkatadri, Rita Basu, Jennie Z. Ma
Publikováno v:
Diabetes. 70
People with diabetes mellitus are more vulnerable to viral infections including influenza and the ongoing COVID-19 pandemic. Fatal pneumonia and cytokine storm is a contributor to the mortality. We hypothesized that aberrant glycemic control induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7412f9c0a3f24bf1e1affa9622ceff50
https://doi.org/10.2337/db21-1140-p
https://doi.org/10.2337/db21-1140-p
Autor:
Marta E. Stremska, Vikram Sabapathy, Sheethal Jose, Rahul Sharma, Chao Dai, Sun-Sang J. Sung, Shu Man Fu, Gaurav Kumar, Hongyang Wang, Rajkumar Venkatadri, Saleh Mohammad
Publikováno v:
J Autoimmun
Lupus glomerulonephritis (GN) is an autoimmune disease characterized by immune complex-deposition, complement activation and glomerular inflammation. In lupus-prone NZM2328 mice, the occurrence of lupus GN was accompanied by a decrease in Treg cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c399c550fc764844c5bde59f6fd0e09
https://doi.org/10.1016/j.jaut.2019.05.005
https://doi.org/10.1016/j.jaut.2019.05.005
Autor:
Vikram Sabapathy, Rahul Sharma, Sanjay Kumar, Murat Dogan, Rajkumar Venkatadri, Gabrielle Costlow
Publikováno v:
Current stem cell researchtherapy. 17(3)
The advent of organoids has renewed researchers' interest in in vitro cell culture systems. A wide variety of protocols, primarily utilizing pluripotent stem cells, are under development to improve organoid generation to mimic organ development. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44c5a1caabfd4d1bc548b5b4f0a8ec8
https://pubmed.ncbi.nlm.nih.gov/34348631
https://pubmed.ncbi.nlm.nih.gov/34348631
Autor:
Rohan Sharma, Vikram Sabapathy, Saleh Mohammad, Charles S. Via, Murat Dogan, Rajkumar Venkatadri, Rahul Sharma
Publikováno v:
Cell Immunol
Previously, we generated IL233 - a hybrid cytokine composed of interleukin (IL)-2 and IL-33, with better therapeutic potential than either cytokine in multiple inflammatory diseases, in part through promoting T-regulatory cells (Tregs). Here we test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93873e60520f9ad716abd03a997170e6
https://pubmed.ncbi.nlm.nih.gov/33831754
https://pubmed.ncbi.nlm.nih.gov/33831754