Moving the goalposts into unblinded territory: lessons of DEFER and FAME 2 and their implications for shifting end points in ISCHEMIA

Autor: Rajkumar, CA, Nijjer, SS, Cole, GD, Al-Lamee, R, Francis, DP

At its conception, a randomized controlled trial is carefully designed to detect a significant effect of an intervention on a prespecified primary end point. Each aspect of a trial is deliberately constructed to allow it to answer this principal ques

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::d315a655cf0a89775f8fb90110b00f9f
http://hdl.handle.net/10044/1/63852

REPLY: Let Us Focus on Angina Mechanisms in Many, Not Just Typical Symptoms in a Few.

Autor: Rajkumar CA; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Al-Lamee RK; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom.

Publikováno v: Journal of the American College of Cardiology [J Am Coll Cardiol] 2024 Nov 12; Vol. 84 (20), pp. e277.

Do Current Clinical Guidelines Set Percutaneous Coronary Intervention Up to Fail? Insights From the ORBITA-2 Trial.

Autor: Rajkumar CA; National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., R.K.A.-L.).; Imperial College Healthcare National Health Service Trust, London, United Kingdom (C.A.R., R.K.A.-L.)., Al-Lamee RK; National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., R.K.A.-L.).; Imperial College Healthcare National Health Service Trust, London, United Kingdom (C.A.R., R.K.A.-L.).

Publikováno v: Circulation. Cardiovascular quality and outcomes [Circ Cardiovasc Qual Outcomes] 2024 Sep; Vol. 17 (9), pp. e011201. Date of Electronic Publication: 2024 Sep 17.

N-of-1 Trial of Angina Verification Before Percutaneous Coronary Intervention.

Autor: Rajkumar CA; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom. Electronic address: https://twitter.com/rajkumar_chris., Foley MJ; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Ahmed-Jushuf F; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Simader FA; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Mohsin M; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Ganesananthan S; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Nowbar AN; Barking Havering and Redbridge University Hospitals NHS Trust, London, United Kingdom., Chotai S; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Sen S; Imperial College Healthcare NHS Trust, London, United Kingdom., Petraco R; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Nijjer SS; Imperial College Healthcare NHS Trust, London, United Kingdom., Sehmi J; West Hertfordshire Hospitals NHS Trust, Watford, United Kingdom., Ruparelia N; Imperial College Healthcare NHS Trust, London, United Kingdom; Royal Berkshire NHS Foundation Trust, Reading, United Kingdom., Dungu JN; Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, United Kingdom; Anglia Ruskin University, Chelmsford, United Kingdom., Kabir A; Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, United Kingdom., Tang K; Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, United Kingdom., Gamma R; Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, United Kingdom., Davies JR; Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, United Kingdom; Anglia Ruskin University, Chelmsford, United Kingdom., Kotecha T; Royal Free London NHS Foundation Trust, London, United Kingdom., Cole GD; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Howard JP; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Keeble TR; Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, United Kingdom; Anglia Ruskin University, Chelmsford, United Kingdom., Clesham G; Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, United Kingdom; Anglia Ruskin University, Chelmsford, United Kingdom., O'Kane PD; University Hospitals Dorset NHS Foundation Trust, Bournemouth, United Kingdom., Harrell FE Jr; Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Francis DP; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Shun-Shin MJ; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom., Al-Lamee RK; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom. Electronic address: r.al-lamee13@imperial.ac.uk.

Publikováno v: Journal of the American College of Cardiology [J Am Coll Cardiol] 2024 Jul 02; Vol. 84 (1), pp. 1-12. Date of Electronic Publication: 2024 May 14.

Coronary sinus reducer for the treatment of refractory angina (ORBITA-COSMIC): a randomised, placebo-controlled trial.

Autor: Foley MJ; National Heart and Lung Institute, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK., Rajkumar CA; National Heart and Lung Institute, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK., Ahmed-Jushuf F; National Heart and Lung Institute, Imperial College London, London, UK., Simader FA; National Heart and Lung Institute, Imperial College London, London, UK., Chotai S; National Heart and Lung Institute, Imperial College London, London, UK., Pathimagaraj RH; National Heart and Lung Institute, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK., Mohsin M; National Heart and Lung Institute, Imperial College London, London, UK., Salih A; National Heart and Lung Institute, Imperial College London, London, UK., Wang D; National Heart and Lung Institute, Imperial College London, London, UK., Dixit P; National Heart and Lung Institute, Imperial College London, London, UK., Davies JR; Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, UK; Medical Technology Research Centre, Anglia Ruskin University School of Medicine, Chelmsford, UK., Keeble TR; Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, UK; Medical Technology Research Centre, Anglia Ruskin University School of Medicine, Chelmsford, UK., Cosgrove C; St George's University Hospitals NHS Foundation Trust, London, UK; St George's, University of London, London, UK., Spratt JC; St George's University Hospitals NHS Foundation Trust, London, UK; St George's, University of London, London, UK., O'Kane PD; University Hospitals of Dorset NHS Foundation Trust, Bournemouth, UK., De Silva R; The Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK., Hill JM; The Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK., Nijjer SS; Imperial College Healthcare NHS Trust, London, UK., Sen S; Imperial College Healthcare NHS Trust, London, UK., Petraco R; Imperial College Healthcare NHS Trust, London, UK., Mikhail GW; Imperial College Healthcare NHS Trust, London, UK., Khamis R; Imperial College Healthcare NHS Trust, London, UK., Kotecha T; Royal Free London NHS Foundation Trust, London, UK., Harrell FE; Vanderbilt University School of Medicine, Nashville, TN, USA., Kellman P; Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Francis DP; National Heart and Lung Institute, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK., Howard JP; National Heart and Lung Institute, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK., Cole GD; National Heart and Lung Institute, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK., Shun-Shin MJ; National Heart and Lung Institute, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK., Al-Lamee RK; National Heart and Lung Institute, Imperial College London, London, UK; Imperial College Healthcare NHS Trust, London, UK. Electronic address: r.al-lamee13@imperial.ac.uk.

Publikováno v: Lancet (London, England) [Lancet] 2024 Apr 20; Vol. 403 (10436), pp. 1543-1553. Date of Electronic Publication: 2024 Apr 08.