Exon skipping of TGFβRI affects signalling and ECM expression in hypertrophic scar-derived fibroblasts

Autor: Rajiv S Raktoe, Marion H Rietveld, Jacoba J Out-Luiting, Marianna Kruithof-de Julio, Paul PM van Zuijlen, Remco van Doorn, Abdoelwaheb El Ghalbzouri

Publikováno v: Scars, Burns & Healing, Vol 6 (2020)

Background: In burn patients, wound healing is often accompanied by hypertrophic scar (HS) development, resulting in both functional and aesthetic problems. HSs are characterised by abundant presence of myofibroblasts that contribute to overproductio

Externí odkaz: https://doaj.org/article/4953c9c3c9d64ef4aadc4cd441c4ed64

The effect of TGFβRI inhibition on fibroblast heterogeneity in hypertrophic scar 2D in vitro models

Autor: Jacoba J. Out-Luiting, Rajiv S. Raktoe, Remco van Doorn, Paul P. M. van Zuijlen, Abdoelwaheb El Ghalbzouri, Marianna Kruithof-de Julio, Marion Rietveld

Publikováno v: Burns, 47(7), 1563-1575. Elsevier Limited
Raktoe, R S, Rietveld, M H, Out-Luiting, J J, Kruithof-de Julio, M, van Zuijlen, P P M, van Doorn, R & el Ghalbzouri, A 2021, ' The effect of TGFβRI inhibition on fibroblast heterogeneity in hypertrophic scar 2D in vitro models ', Burns, vol. 47, no. 7, pp. 1563-1575 . https://doi.org/10.1016/j.burns.2021.01.004
Raktoe, Rajiv S; Rietveld, Marion H; Out-Luiting, Jacoba J; Kruithof-de Julio, Marianna; van Zuijlen, Paul P M; van Doorn, Remco; El Ghalbzouri, Abdoelwaheb (2021). The effect of TGFβRI inhibition on fibroblast heterogeneity in hypertrophic scar 2D in vitro models. Burns, 47(7), pp. 1563-1575. Elsevier 10.1016/j.burns.2021.01.004

In burn patients, wound healing is often accompanied by hypertrophic scarring (HTS), resulting in both functional and aesthetic problems. HTSs are characterized by abundant presence of myofibroblasts (MFs) residing in the dermis. HTS development and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48cb5bbc394653670ef819899909a0d

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

Autor: Carlotta Granchi, Elisa Giovannetti, Amir Avan, Babette Aicher, Daniela Massihnia, Mina Maftouh, Leticia G. Leon, Rajiv S. Raktoe, Anne van Krieken, Niccola Funel, Filippo Minutolo, Antonio Russo, Ugo Boggi, Godefridus J. Peters

Publikováno v: Massihnia, D, Avan, A, Funel, N, Maftouh, M, Van Krieken, A, Granchi, C, Raktoe, R, Boggi, U, Aicher, B, Minutolo, F, Russo, A, Leon, L G, Peters, G J & Giovannetti, E 2017, ' Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer ', Journal of Hematology and Oncology, vol. 10, no. 1, 9 . https://doi.org/10.1186/s13045-016-0371-1
Journal of Hematology & Oncology
Journal of Hematology and Oncology, 10(1):9. BioMed Central
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-17 (2017)

Background There is increasing evidence of a constitutive activation of Akt in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and chemoresistance. Therefore, we evaluated the expression of phospho-Akt in PDAC tissues and cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0527d043c396c119ac955e1ab571ea8
https://research.vumc.nl/en/publications/e3915272-5f2e-4b5f-a149-4af093da963c

Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis

Autor: W. Peter Vandertop, Rajiv S. Raktoe, Judith W. M. Jeuken, David P. Noske, Gertjan J.L. Kaspers, Thomas Wurdinger, Esther Hulleman, Pieter Wesseling, Lotte Hiddingh

Publikováno v: Scientific Reports
Scientific reports, 4. Nature Publishing Group
Scientific Reports, 4
Scientific Reports, 4:5260. Nature Publishing Group
Hiddingh, L, Raktoe, R S, Jeuken, J, Hulleman, E, Noske, D P, Kaspers, G J, Vandertop, W P, Wesseling, P & Wurdinger, T 2014, ' Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis ', Scientific Reports, vol. 4, 5260 . https://doi.org/10.1038/srep05260

Contains fulltext : 138214.pdf (Publisher’s version ) (Open Access) Drug resistance is a major issue in the treatment of glioblastoma. Almost all glioblastomas are intrinsically resistant to chemotherapeutic temozolomide (TMZ) or develop resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426cf32e8bcca401240f4f5ad48024ac
http://europepmc.org/articles/PMC4052714

European Tissue Repair Society Meeting ‐ 2022: With the participation of Cosmet'in Lyon, Aderly and LyonBiopole.

Publikováno v: Wound Repair & Regeneration. Sep2022, Vol. 30 Issue 5, pA1-A36. 36p.