Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Rajiv R, Ratan"'
Autor:
Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn
Externí odkaz:
https://doaj.org/article/a0cf0ed0ee2143f0a980d7d5a5c6d50a
Autor:
Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan
Publikováno v:
eLife, Vol 10 (2021)
Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second m
Externí odkaz:
https://doaj.org/article/5101dfdcd63d48c8a22c4fac2e9e0afc
Autor:
Joe C. Udeochu, Sadaf Amin, Yige Huang, Li Fan, Eileen Ruth S. Torres, Gillian K. Carling, Bangyan Liu, Hugo McGurran, Guillermo Coronas-Samano, Grant Kauwe, Gergey Alzaem Mousa, Man Ying Wong, Pearly Ye, Ravi Kumar Nagiri, Iris Lo, Julia Holtzman, Carlo Corona, Allan Yarahmady, Michael T. Gill, Ravikiran M. Raju, Sue-Ann Mok, Shiaoching Gong, Wenjie Luo, Mingrui Zhao, Tara E. Tracy, Rajiv R. Ratan, Li-Huei Tsai, Subhash C. Sinha, Li Gan
Publikováno v:
Nature Neuroscience. 26:737-750
Pathological hallmarks of Alzheimer’s disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia. Here, we report that activation of cyclic GMP–AMP synthase (cGAS) diminishes cognitiv
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105145- (2021)
A major thrust of our laboratory has been to identify how physiological stress is transduced into transcriptional responses that feed back to overcome the inciting stress or its consequences, thereby fostering survival and repair. To this end, we hav
Externí odkaz:
https://doaj.org/article/061199407e804797a4505ad711ddd33c
Autor:
George Z Wei, Sujata Saraswat Ohri, Nicolas K Khattar, Adam W Listerman, Catherine H Doyle, Kariena R Andres, Saravanan S Karuppagounder, Rajiv R Ratan, Scott R Whittemore, Michal Hetman
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249591 (2021)
Traumatic spinal cord injury (SCI) is a devastating neurological condition that involves both primary and secondary tissue loss. Various cytotoxic events including hypoxia, hemorrhage and blood lysis, bioenergetic failure, oxidative stress, endoplasm
Externí odkaz:
https://doaj.org/article/afcf059cd1dc42a1bcc67fbc7242ecef
Autor:
Pascaline Aimé, Saravanan S. Karuppagounder, Apeksha Rao, Yingxin Chen, Robert E. Burke, Rajiv R. Ratan, Lloyd A. Greene
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104725- (2020)
Identifying disease-causing pathways and drugs that target them in Parkinson's disease (PD) has remained challenging. We uncovered a PD-relevant pathway in which the stress-regulated heterodimeric transcription complex CHOP/ATF4 induces the neuron pr
Externí odkaz:
https://doaj.org/article/e4d8cb29d6394909a61a7bb6794439bf
Autor:
Rajiv R, Ratan
Publikováno v:
Neuron. 110:3219-3222
Chemobrain is a variable but debilitating consequence of lifesaving cancer treatments. In this issue of Neuron, Jang and colleagues provide a new conceptual framework based on choroid plexus-CSF antioxidant status that advances understanding of chemo
Autor:
Joshua Silverstein, Mar Cortes, Katherine Zoe Tsagaris, Alejandra Climent, Linda M. Gerber, Clara Oromendia, Pasquale Fonzetti, Rajiv R. Ratan, Tomoko Kitago, Marco Iacoboni, Allan Wu, Bruce Dobkin, Dylan J. Edwards
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Background and PurposeThe potential for adaptive plasticity in the post-stroke brain is difficult to estimate, as is the demonstration of central nervous system (CNS) target engagement of drugs that show promise in facilitating stroke recovery. We se
Externí odkaz:
https://doaj.org/article/b8b789c34e824872844ea8c436777eff
Autor:
Tomoko Kitago, Rajiv R. Ratan
Publikováno v:
F1000Research, Vol 6 (2017)
Intracerebral hemorrhage (ICH), a form of brain bleeding and minor subtype of stroke, leads to significant mortality and long-term disability. There are currently no validated approaches to promote functional recovery after ICH. Research in stroke re
Externí odkaz:
https://doaj.org/article/6cd164eca3b744388f0255167d468299
Autor:
Marietta Zille, Juan A. Oses-Prieto, Sara R. Savage, Saravanan S. Karuppagounder, Yingxin Chen, Amit Kumar, John H. Morris, Karl A. Scheidt, Alma L. Burlingame, Rajiv R. Ratan
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 42, iss 10
J Neurosci
J Neurosci
Ferroptosis is a caspase-independent, iron-dependent form of regulated necrosis extant in traumatic brain injury, Huntington disease, and hemorrhagic stroke. It can be activated by cystine deprivation leading to glutathione depletion, the insufficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c4987a4d1b76158a4974368bc3e3f3
https://escholarship.org/uc/item/7904g2wz
https://escholarship.org/uc/item/7904g2wz