Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Rajiv L. Joshi"'
Autor:
Eugenie Peze-Heidsieck, Tom Bonnifet, Rania Znaidi, Camille Ravel-Godreuil, Olivia Massiani-Beaudoin, Rajiv L. Joshi, Julia Fuchs
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
The etiology of aging-associated neurodegenerative diseases (NDs), such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), still remains elusive and no curative treatment is available. Age is the major risk factor for PD and AD, but the mo
Externí odkaz:
https://doaj.org/article/c66c3175da2944cb84e3fc346884a932
Autor:
Camille Ravel-Godreuil, Olivia Massiani-Beaudoin, Philippe Mailly, Alain Prochiantz, Rajiv L. Joshi, Julia Fuchs
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102756- (2021)
Summary: Age is a major risk factor for neurodegenerative diseases like Parkinson’s disease, but few studies have explored the contribution of key hallmarks of aging, namely DNA methylation changes and heterochromatin destructuration, in the neurod
Externí odkaz:
https://doaj.org/article/68a9de6da70348f1b6386111b62eb912
Autor:
Hocine Rekaik, François-Xavier Blaudin de Thé, Julia Fuchs, Olivia Massiani-Beaudoin, Alain Prochiantz, Rajiv L. Joshi
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 242-250 (2015)
Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to th
Externí odkaz:
https://doaj.org/article/b2324fb06af645a095c7fd0562e7ee82
Autor:
Ulrika Nordström, Geneviève Beauvais, Anamitra Ghosh, Baby Chakrapani Pulikkaparambil Sasidharan, Martin Lundblad, Julia Fuchs, Rajiv L. Joshi, Jack W. Lipton, Andrew Roholt, Satish Medicetty, Timothy N. Feinstein, Jennifer A. Steiner, Martha L. Escobar Galvis, Alain Prochiantz, Patrik Brundin
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 70-82 (2015)
Current research on Parkinson's disease (PD) pathogenesis requires relevant animal models that mimic the gradual and progressive development of neuronal dysfunction and degeneration that characterizes the disease. Polymorphisms in engrailed 1 (En1),
Externí odkaz:
https://doaj.org/article/5ecbd7f88ea046b8b6a6dce32b3f3ab4
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
A number of transcription factors, including En1/2, Foxa1/2, Lmx1a/b, Nurr1, Otx2, and Pitx3, with key roles in midbrain dopaminergic (mDA) neuron development, also regulate adult mDA neuron survival and physiology. Mouse models with targeted disrupt
Externí odkaz:
https://doaj.org/article/bf32e04f1e9741b1acdcbdfeea52f41b
Publikováno v:
FEBS lettersReferences. 595(22)
Neurodegenerative diseases (NDs), including the most prevalent Alzheimer's disease and Parkinson disease, share common pathological features. Despite decades of gene-centric approaches, the molecular mechanisms underlying these diseases remain widely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbd360132f2e64593719d1c28a5a1c8
https://pubmed.ncbi.nlm.nih.gov/34626428
https://pubmed.ncbi.nlm.nih.gov/34626428
Autor:
Olivia Massiani-Beaudoin, Rajiv L. Joshi, Philippe Mailly, Julia Fuchs, Camille Ravel-Godreuil, Alain Prochiantz
Publikováno v:
SSRN Electronic Journal.
Heterochromatin disorganization is a key hallmark of aging and DNA methylation state is currently the main molecular predictor of chronological age. The most frequent neurodegenerative diseases like Parkinson disease and Alzheimer’s disease are age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d772740077ad75401f9f6c5bdbf435d
https://doi.org/10.2139/ssrn.3773808
https://doi.org/10.2139/ssrn.3773808
Autor:
Wei Zhang, Poki Chen, Naehyuck Chang, Eren Kursun, Makoto Nagata, M. Elfadel, Huawei Li, Partha Pratim Pande, Tae-Hyoung Kim, Ioannis Savidis, Houman Homayoun, Krishnendu Chakrabarty, Yuh-Shyan Hwang, Chirn Chye Boon, Patrick Mercier, Shih-Chieh Chang, Arun Natarajan, Chip-Hong Ho, Maxime Baas, Sheldon X.-D. Tan, Said Hamdioui, Mingoo Seok, Mehran Mozaffari Kermani, Aida Todri-Sanial, Koji Nii, Jaydeep P. Kulkarni, Masanori Hashimoto, Tsung-Yi Ho, Pasquale Corsonello, Massimo Alioto, Masud H. Chowdhury, Chulwoo Kim, Meng-Fan Chang, Hai Helen Li, Tanay Tan, Yao-Wen Chang, M. Tehranipoor, Prabhat Mishra, Stacey Weber Jackson, Zhengya Zhang, Rajiv L Joshi, Erik G. Larsson, Jiang Xu, Miroslav N. Velev
Publikováno v:
IEEE Transactions on Very Large Scale Integration (VLSI) Systems. 25:1-20
As I start my second two-year term (2017–2018) as the Editor-in-Chief (EIC) of the IEEE Transactions on Very Large Scale Integration Systems (TVLSI), I wish the TVLSI readership a very happy new year and continued professional success. It gives me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac0580c412083b9bf3d152a5baf420e5
https://doi.org/10.1109/tvlsi.2016.2638578
https://doi.org/10.1109/tvlsi.2016.2638578
Autor:
Julia Fuchs, Olivier Stettler, Kenneth L. Moya, Alain Prochiantz, Rajiv L. Joshi, Daniel Alvarez-Fischer
Publikováno v:
European Journal of Neuroscience. 35:1837-1845
Several homeoproteins can function in a direct cell non-autonomous fashion to control various biological processes. In the developing nervous system, this mode of signaling has been well documented for Engrailed in the guidance of retinal ganglion ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9049502e461db5bb0243ddc4d4ccc5e
https://doi.org/10.1111/j.1460-9568.2012.08139.x
https://doi.org/10.1111/j.1460-9568.2012.08139.x
Publikováno v:
Diabetologia
Diabetologia, Springer Verlag, 2002, 45 (9), pp.1292-1297. ⟨10.1007/s00125-002-0881-y⟩
Diabetologia, Springer Verlag, 2002, 45 (9), pp.1292-1297. ⟨10.1007/s00125-002-0881-y⟩
Insulin receptor null mutant mice develop severe diabetes, ketoacidosis and liver steatosis and die within 1 week after birth. Since the liver plays an essential role in the control of glucose homeostasis, we examined in this work whether the metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0978e8d3d17aa46e9b6dfa668b7e0d59
https://doi.org/10.1007/s00125-002-0881-y
https://doi.org/10.1007/s00125-002-0881-y