Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Rajiv Kumar Jha"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis. MYC interacts with
Externí odkaz:
https://doaj.org/article/069c4fe469764f01a3ffd8e63cd0ee40
Autor:
Khushboo Shrivastava, Lucky Sriwastwa, Priyanka Shrivastava, Tirumala Kanakadurga Sripati, Rajiv Kumar Jha
Publikováno v:
Student's Journal of Health Research Africa, Vol 4, Iss 9 (2023)
Introduction: Nasopharyngeal carcinoma (NPC) is a very uncommon malignant tumour in children under the age of 20. The diagnosis of paediatric NPC is challenging due to its relative rarity. This unusual occurrence is frequently linked to delayed diagn
Externí odkaz:
https://doaj.org/article/e62fb622fe8a4075a0b5d26deaa379ba
Publikováno v:
Nucleus, Vol 13, Iss 1, Pp 94-115 (2022)
The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin. The resulting structures modulate essential nuclea
Externí odkaz:
https://doaj.org/article/63baff40c29b499db4398681042d3549
Autor:
Di Chen, Xinyue Wei, Ke Yang, Xinyue Liu, Yujin Song, Futing Bai, Yi Jiang, Yuhang Guo, Rajiv Kumar Jha
Publikováno v:
Journal of International Medical Research, Vol 50 (2022)
Objective To investigate the effects of piperlongumine (PL) and vitamin C (VC) on signal transducer and activator of transcription 3 (STAT3) signalling in gastric cancer cell lines. Methods In vivo tumour xenograft anticancer assays were undertaken t
Externí odkaz:
https://doaj.org/article/6376f9354f3044b4887da74c2ae27b22
Autor:
Kushi Anand, Ashutosh Tripathi, Kaustubh Shukla, Nitish Malhotra, Anil Kumar Jamithireddy, Rajiv Kumar Jha, Susmit Narayan Chaudhury, Raju S. Rajmani, Arati Ramesh, Valakunja Nagaraja, Balasubramanian Gopal, Ganesh Nagaraju, Aswin Sai Narain Seshayee, Amit Singh
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102062- (2021)
The persistence of Mycobacterium tuberculosis (Mtb) is a major problem in managing tuberculosis (TB). Host-generated nitric oxide (NO) is perceived as one of the signals by Mtb to reprogram metabolism and respiration for persistence. However, the mec
Externí odkaz:
https://doaj.org/article/f27f2c6c658841d4a14f455bde7ee069
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
At present, the clinical diagnosis of and treatment methods for hepatic carcinoma still fail to fully meet the needs of patients. The integrated theranostic system, in which functional materials are used to load different active molecules, created a
Externí odkaz:
https://doaj.org/article/37c08ffdd0284ac4b6f9fd6b78d7a214
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Combination chemotherapy has been proven to be an efficient strategy for the treatment of prostate cancer (PCA). However, the pharmacokinetic distinction between the relevant drugs is an insurmountable barrier to the realization of their synergistic
Externí odkaz:
https://doaj.org/article/b98cb3af139c4331a78228bd3ddc71f5
Publikováno v:
Journal of College of Medical Sciences-Nepal, Vol 11, Iss 3, Pp 12-15 (2015)
Background & Objectives: Injury to Anterior Cruciate Ligament (ACL) reconstruction has increased because of increased interest in sports. There are various grafts used for reconstruction of ACL, for example, Bone Patellar Tendon Bone, Hamstring etc.
Externí odkaz:
https://doaj.org/article/5bfec0561ab44a73847cbce79ce20cf2
Autor:
Wareed Ahmed, Claudia Sala, Shubhada R Hegde, Rajiv Kumar Jha, Stewart T Cole, Valakunja Nagaraja
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006754 (2017)
Movement of the transcription machinery along a template alters DNA topology resulting in the accumulation of supercoils in DNA. The positive supercoils generated ahead of transcribing RNA polymerase (RNAP) and the negative supercoils accumulating be
Externí odkaz:
https://doaj.org/article/6d4567ad243846628ffff8c2c9e88a87
Autor:
Saurabh Mishra, Prashant Shukla, Ashima Bhaskar, Kushi Anand, Priyanka Baloni, Rajiv Kumar Jha, Abhilash Mohan, Raju S Rajmani, Valakunja Nagaraja, Nagasuma Chandra, Amit Singh
Publikováno v:
eLife, Vol 6 (2017)
Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams. Nonetheless, β-lactams showed mycobactericidal activity in combination with β-lactam
Externí odkaz:
https://doaj.org/article/d811501a595641efbdfc414e2992d5c8