Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Rajiv Gandhi Govindaraj"'
Autor:
Rajiv Gandhi Govindaraj, Sundar Thangapandian, Michael Schauperl, Rajiah Aldrin Denny, David J. Diller
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Interest in exploiting allosteric sites for the development of new therapeutics has grown considerably over the last two decades. The chief driving force behind the interest in allostery for drug discovery stems from the fact that in comparison to or
Externí odkaz:
https://doaj.org/article/48fdad24dd4041ffbd38fe6999da2e79
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background Detecting similar ligand-binding sites in globally unrelated proteins has a wide range of applications in modern drug discovery, including drug repurposing, the prediction of side effects, and drug-target interactions. Although a
Externí odkaz:
https://doaj.org/article/7d6e2dbcd36f4b62bde1b9737a01837d
Autor:
Limeng Pu, Rajiv Gandhi Govindaraj, Jeffrey Mitchell Lemoine, Hsiao-Chun Wu, Michal Brylinski
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006718 (2019)
Comprehensive characterization of ligand-binding sites is invaluable to infer molecular functions of hypothetical proteins, trace evolutionary relationships between proteins, engineer enzymes to achieve a desired substrate specificity, and develop dr
Externí odkaz:
https://doaj.org/article/bdeba66fe3ff49e7bd677e3cc524d74e
Autor:
Maheswaran Easwaran, Rajiv Gandhi Govindaraj, Misagh Naderi, Michal Brylinski, Mahanama Zoysa, HYUN-JIN SHIN, Eui-Ju Hong
Bacteriophage-encoded endolysins have been recognized as promising antibacterial specialists for combating antibiotic-resistant bacteria. Endolysins have been restricted in the case of treatment of Gram-negative bacteria exogenously, where the outer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38309255c2d36bddd074e10924d58cb3
https://doi.org/10.21203/rs.3.rs-2192264/v1
https://doi.org/10.21203/rs.3.rs-2192264/v1
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Identification of B-cell epitopes (BCEs) is a fundamental step for epitope-based vaccine development, antibody production, and disease prevention and diagnosis. Due to the avalanche of protein sequence data discovered in postgenomic age, it is essent
Externí odkaz:
https://doaj.org/article/8dda842f8e044cf5814d3c0f0a585b7f
Publikováno v:
Journal of Molecular Biology. 430:2266-2273
About 7000 rare, or orphan, diseases affect more than 350 million people worldwide. Although these conditions collectively pose significant health care problems, drug companies seldom develop drugs for orphan diseases due to extremely limited individ
Autor:
Misagh Naderi, Jeffrey Mitchell Lemoine, Manali Singha, Michal Brylinski, Rajiv Gandhi Govindaraj
Publikováno v:
npj Systems Biology and Applications, Vol 4, Iss 1, Pp 1-10 (2018)
NPJ Systems Biology and Applications
NPJ Systems Biology and Applications
Rare, or orphan, diseases are conditions afflicting a small subset of people in a population. Although these disorders collectively pose significant health care problems, drug companies require government incentives to develop drugs for rare diseases
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25118 (2011)
Toll-like receptors (TLRs) play a central role in the innate immune response by recognizing conserved structural patterns in a variety of microbes. TLRs are classified into six families, of which TLR7 family members include TLR7, 8, and 9, which are
Externí odkaz:
https://doaj.org/article/91d375d6701f4cf0bc88c91836ceb611
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23989 (2011)
Toll-like receptors (TLRs) activate a potent immunostimulatory response. There is clear evidence that overactivation of TLRs leads to infectious and inflammatory diseases. Recent biochemical studies have shown that the membrane-bound form of ST2 (ST2
Externí odkaz:
https://doaj.org/article/e67f37a8c13f4df1a356e4d4e189c0c9
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12713 (2010)
Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogens based on distinct molecular signatures. The human (h)TLR1, 2, 6 and 10 belong to the hTLR1 subfamilies, which are localized in the extracellular regions and activat
Externí odkaz:
https://doaj.org/article/78c68683f4cb4b3f84f03e924d74f48b