CD81-Receptor Associations — Impact for Hepatitis C Virus Entry and Antiviral Therapies

Autor: Laetitia Zona, Rajiv G. Tawar, Mirjam B. Zeisel, Fei Xiao, Catherine Schuster, Joachim Lupberger, Thomas F. Baumert

Publikováno v: Viruses, Vol 6, Iss 2, Pp 875-892 (2014)

Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspanins and molecular partners. Among them, CD81 has been implicated in a variety of physiological and pathological

Externí odkaz: https://doaj.org/article/59ba231ab65248b58972e31547332e04

Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape

Autor: Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert

Publikováno v: Gut
Gut, BMJ Publishing Group, 2018, 67 (4), pp.736-745. ⟨10.1136/gutjnl-2016-312577⟩
Gut, 2018, 67 (4), pp.736-745. ⟨10.1136/gutjnl-2016-312577⟩

International audience; OBJECTIVE:HCV infection is a leading cause of chronic liver disease and a major indication for liver transplantation. Although direct-acting antivirals (DAAs) have much improved the treatment of chronic HCV infection, alternat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::da789822e462534611749ff06f5856fa
https://pubmed.ncbi.nlm.nih.gov/28360099

Acute hepatitis C virus infection induces anti-host cell receptor antibodies with virus-neutralizing properties

Autor: Tanja Fehm, Thomas Berg, Michael Roggendorf, Jörg Timm, François Habersetzer, Thomas F. Baumert, Nicolas Meyer, Rajiv G. Tawar, Mirjam B. Zeisel, Che C. Colpitts, François-Loïc Cosset, Helga Meisel

Publikováno v: Hepatology
Hepatology, 2015, 62 (3), pp.726-736. ⟨10.1002/hep.27906⟩
Hepatology, Wiley-Blackwell, 2015, 62 (3), pp.726-736. ⟨10.1002/hep.27906⟩

Hepatitis C virus (HCV) causes persistent infection in the majority of infected individuals. The mechanisms of persistence and clearance are only partially understood. Antibodies (Abs) against host cell entry receptors have been shown to inhibit HCV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57278fe232fa2cfbb0a6696afe55f1d5
https://hal.science/hal-01908875

A new HCV mouse model on the block

Autor: Laurent Mailly, Thomas F. Baumert, Rajiv G. Tawar

Publikováno v: Cell Research

The majority of hepatitis C virus (HCV) infection develops chronic infection, which causes steatosis, cirrhosis and hepatocellular carcinoma. However, understanding HCV chronicity and pathogenesis is hampered by its narrow host range, mostly restrict

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7539b020560f7db921cf16f561b8dbfd
https://pubmed.ncbi.nlm.nih.gov/25155355

A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmission

Autor: Isabel Fofana, Christine Thumann, Fritz Grunert, Thomas F. Baumert, Fei Xiao, Marine Turek, Rajiv G. Tawar, John F. Thompson, Laetitia Zona, Mirjam B. Zeisel

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (5), pp.e64221. ⟨10.1371/journal.pone.0064221⟩
PLoS ONE, Vol 8, Iss 5, p e64221 (2013)
PLoS ONE, 2013, 8 (5), pp.e64221. ⟨10.1371/journal.pone.0064221⟩

International audience; BACKGROUND AND AIMS: Hepatitis C virus (HCV) infection is a challenge to prevent and treat because of the rapid development of drug resistance and escape. Viral entry is required for initiation, spread, and maintenance of infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8bf753bcabd615d7d511d75b3d08f5
https://www.hal.inserm.fr/inserm-00850895