Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rajiv, Sainath"'
Autor:
Rajiv Sainath, Gianluca Gallo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Nerve Growth Factor (NGF) promotes the elaboration of axonal filopodia and branches through PI3K-Akt. NGF activates the TrkA receptor resulting in an initial transient high amplitude burst of PI3K-Akt signaling followed by a maintained lower steady s
Externí odkaz:
https://doaj.org/article/cc4f81b5a2274165924fb66c7d9ef054
Autor:
Lorena Armijo-Weingart, Andrea Ketschek, Rajiv Sainath, Almudena Pacheco, George M Smith, Gianluca Gallo
Publikováno v:
eLife, Vol 8 (2019)
Neurotrophins are growth factors that have a multitude of roles in the nervous system. We report that neurotrophins induce the fission of mitochondria along embryonic chick sensory axons driven by combined PI3K and Mek-Erk signaling. Following an ini
Externí odkaz:
https://doaj.org/article/b3648824016e483984f4581d13af0e18
Publikováno v:
J Neurosci
Understanding the bioenergetics of axon extension and maintenance has wide ranging implications for neurodevelopment and disease states. Glycolysis is a pathway consisting of 10 enzymes and separated into preparatory and payoff phases, the latter pro
Autor:
Rajiv Sainath, Michael Granato
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54071 (2013)
During embryogenesis motor axons navigate to their target muscles, where individual motor axons develop complex branch morphologies. The mechanisms that control axonal branching morphogenesis have been studied intensively, yet it still remains unclea
Externí odkaz:
https://doaj.org/article/11eec2f220de40eba94bb364307668f8
Autor:
Andrea Ketscheck, Lorena Armijo-Weingart, Shuxin Li, Zhuxuan Xu, Rajiv Sainath, Gianluca Gallo
Publikováno v:
Developmental Neurobiology. 77:1351-1370
Chondroitin sulfate proteoglycans (CSPGs) are components of the extracellular matrix that inhibit the extension and regeneration of axons. However, the underlying mechanism of action remains poorly understood. Mitochondria and endoplasmic reticulum (
Publikováno v:
Developmental Neurobiology. 77:454-473
Chondroitin sulfate proteoglycans (CSPGs) inhibit the formation of axon collateral branches. The regulation of the axonal cytoskeleton and mitochondria are important components of the mechanism of branching. Actin-dependent axonal plasticity, reflect
Autor:
Gianluca Gallo, Rajiv Sainath
Publikováno v:
Developmental Neurobiology. 75:757-777
The axonal transport of organelles is critical for the development, maintenance, and survival of neurons, and its dysfunction has been implicated in several neurodegenerative diseases. Retrograde axon transport is mediated by the motor protein dynein
Autor:
Rajiv, Sainath, Lorena, Armijo-Weingart, Andrea, Ketscheck, Zhuxuan, Xu, Shuxin, Li, Gianluca, Gallo
Publikováno v:
Developmental neurobiology. 77(12)
Chondroitin sulfate proteoglycans (CSPGs) are components of the extracellular matrix that inhibit the extension and regeneration of axons. However, the underlying mechanism of action remains poorly understood. Mitochondria and endoplasmic reticulum (
Autor:
Gianluca Gallo, Rajiv Sainath
The formation of a neurite, the basis for axons and dendrites, begins with the concerted accumulation and organization of actin and microtubules. Whereas much is known about the proteins that play a role in these processes, because they perform simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed330bf054df39fd21f16e0c235cf69
https://europepmc.org/articles/PMC4286448/
https://europepmc.org/articles/PMC4286448/