Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Rajiv, Raja"'
Autor:
Rania Dagher, Alan M. Copenhaver, Valerie Besnard, Aaron Berlin, Fatima Hamidi, Marielle Maret, Jingya Wang, Xiaotao Qu, Yashaswi Shrestha, Jincheng Wu, Gregory Gautier, Rajiv Raja, Michel Aubier, Roland Kolbeck, Alison A. Humbles, Marina Pretolani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Signaling of IL-33 via its receptor, ST2, has been implicated in macrophage function in tissue repair. Here the authors show, using genetic mouse models and single-cell transcriptomic data, that the IL-33/ST2 axis regulates both ILC2-derived IL-13 an
Externí odkaz:
https://doaj.org/article/dfa2aff3dc9744c0adab9ba6f648aaa3
Autor:
Sophie Wildsmith, Weimin Li, Song Wu, Ross Stewart, Nassim Morsli, Rajiv Raja, Qu Zhang, Jiabu Ye, Philip He, Jagdish Shetty, Alejandro Yovine, Nicholas Holoweckyj, Katia Real, Jill Walker, Magdalena Wrona, Melissa de los Reyes, Craig Barker, Jessica Whiteley, Robert Haddad, Lisa Licitra, Robert Ferris, Jérôme Fayette, Dan P. Zandberg, Lillian L. Siu, Ricard Mesía
Publikováno v:
Clinical Cancer Research. 29:2066-2074
Purpose: Biomarkers that predict response to immune checkpoint inhibitors (ICI) in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) are needed. This retrospective study assessed tumor mutational burden (TMB) and outcomes in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::911eb9ff1492de58a03ea819de5f5d9a
https://doi.org/10.1158/1078-0432.ccr-22-2765
https://doi.org/10.1158/1078-0432.ccr-22-2765
Autor:
Weimin Li, Ross Stewart, Thomas Powles, Joaquim Bellmunt, Feng Xiao, Ashok Gupta, Jill Walker, Melissa de los Reyes, Matthew Galsky, Sophie Wildsmith, Anne L’Hernault, Hannah Bye, Philip He, Qu Zhang, Rajiv Raja, Wendy Levin, Alexandra Drakaki, Michiel van der Heijden
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/bfecfa2ec4564ebcbea8a373a6c1ea02
Autor:
Taylor S. Cohen, Michelle L. Boland, Brandon B. Boland, Virginia Takahashi, Andrey Tovchigrechko, Young Lee, Aimee D. Wilde, Mark J. Mazaitis, Omari Jones-Nelson, Christine Tkaczyk, Rajiv Raja, C. Kendall Stover, Bret R. Sellman
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2431-2441 (2018)
Summary: Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT neutralization, protects mice from lethal S. aureus pneumonia. We tes
Externí odkaz:
https://doaj.org/article/5ce6e8afcf3447d3a86bea39073220d6
Autor:
Ricard Mesía, Lillian L. Siu, Dan P. Zandberg, Jérôme Fayette, Robert Ferris, Lisa Licitra, Robert Haddad, Jessica Whiteley, Craig Barker, Melissa de los Reyes, Magdalena Wrona, Jill Walker, Katia Real, Nicholas Holoweckyj, Alejandro Yovine, Jagdish Shetty, Philip He, Jiabu Ye, Qu Zhang, Rajiv Raja, Nassim Morsli, Ross Stewart, Song Wu, Weimin Li, Sophie Wildsmith
FIG S2. Kaplan-Meier plot of OS in the durvalumab monotherapy, durvalumab plus tremelimumab and SoC treatment arms in the NLR ≤ 7 subgroup (A) and NLR > 7 subgroup (B) in EAGLE.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a87e88a11e0049916dc65f88972d18
https://doi.org/10.1158/1078-0432.22551834.v1
https://doi.org/10.1158/1078-0432.22551834.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Clinical activity with durvalumab plus tremelimumab in patients from Study 006 with STK11mut and STK11wt tumors, characterized by tumor cell PD-L1 expression (high [{greater than or equal to}25%] or low [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015148eacf1bb63fec08850aef2c2e00
https://doi.org/10.1158/2159-8290.22540406.v1
https://doi.org/10.1158/2159-8290.22540406.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Pharmacodynamics of STAT3 ASO in CT26 STK11 KO model. (A) Percentage of CD45+ immune cells among live cells from untreated or drug-treated STK11 KO CT26 tumors as indicated. (B) Percentage of Ly6G+ granulocytic cells among live CD45+ cells. (C) Perce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c1f0437b345d54961ba0824610dcb6
https://doi.org/10.1158/2159-8290.22540439.v1
https://doi.org/10.1158/2159-8290.22540439.v1
Autor:
David A. Tice, Ronald Herbst, Andrew J. Pierce, Jay Harper, Rajiv Raja, Nicholas Holoweckyj, Brandon W. Higgs, James Conway, Maureen Kennedy, Christine Fazenbaker, Jing Zhang, Shannon Breen, Ravinder Tammali, Cui Chen, Haihong Zhong
Supplemental Figure S1: Knockdown of BRCA1 or BRCA2 sensitizes Hela cells to PBD payload and PBD-based ADC in vitro. Supplemental Figure S2: Genetic deletion of BRCA1 sensitizes cells to PBD-based ADC. Supplemental Table S1: BRCA mutation(s) in patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287f5a606ce990a7e443afbe48eb07df
https://doi.org/10.1158/1535-7163.22510440
https://doi.org/10.1158/1535-7163.22510440
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Supplementary Appendix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ac7dc7f83ade0389ea5b8926dfead1
https://doi.org/10.1158/2159-8290.22540454.v1
https://doi.org/10.1158/2159-8290.22540454.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99faa4f93ebec463e8a33a4c093c1abb
https://doi.org/10.1158/2159-8290.c.6549368.v1
https://doi.org/10.1158/2159-8290.c.6549368.v1