Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Rajita, Pappu"'
Autor:
Arivazhagan Sambandam, Elaine Storm, Helen Tauc, Jason A. Hackney, David Garfield, Patrick Caplazi, John Liu, Juan Zhang, Hua Zhang, Jeff Duggan, Surinder Jeet, Sarah Gierke, Patrick Chang, Xiumin Wu, Robert Newman, Lucinda Tam, Tuija Alcantar, Lifen Wang, Meron Roose-Girma, Zora Modrusan, Wyne P. Lee, Heinrich Jasper, Frederic de Sauvage, Rajita Pappu
Publikováno v:
Heliyon, Vol 9, Iss 3, Pp e14238- (2023)
The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state maintenance of tissues with high turnover such as the blood and intestine. Mutations that alter these processes can cause primary immunodeficiencies, m
Externí odkaz:
https://doaj.org/article/5f0b411f56a24ccdae5dfc7e215eea4e
Autor:
Michael, Waters, James A, McKinnell, Andre C, Kalil, Greg S, Martin, Timothy G, Buchman, Wiebke, Theess, Xiaoying, Yang, Annemarie N, Lekkerkerker, Tracy, Staton, Carrie M, Rosenberger, Rajita, Pappu, Yehong, Wang, Wenhui, Zhang, Logan, Brooks, Dorothy, Cheung, Joshua, Galanter, Hubert, Chen, Divya, Mohan, Melicent C, Peck
Publikováno v:
Critical Care Medicine. 51:103-116
Severe cases of COVID-19 pneumonia can lead to acute respiratory distress syndrome (ARDS). Release of interleukin (IL)-33, an epithelial-derived alarmin, and IL-33/ST2 pathway activation are linked with ARDS development in other viral infections. IL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07e031bf85b5800f7352d5492dabc05
https://doi.org/10.1097/ccm.0000000000005716
https://doi.org/10.1097/ccm.0000000000005716
Autor:
Joseph Chavarria-Smith, Cecilia P.C. Chiu, Janet K. Jackman, Jianping Yin, Juan Zhang, Jason A. Hackney, Wei-Yu Lin, Tulika Tyagi, Yonglian Sun, Janet Tao, Debra Dunlap, William D. Morton, Swapnil V. Ghodge, Henry R. Maun, Hong Li, Hilda Hernandez-Barry, Kelly M. Loyet, Emily Chen, John Liu, Christine Tam, Brian L. Yaspan, Hao Cai, Mercedesz Balazs, Joseph R. Arron, Jing Li, Arthur J Wittwer, Rajita Pappu, Cary D. Austin, Wyne P. Lee, Robert A. Lazarus, Jawahar Sudhamsu, James T. Koerber, Tangsheng Yi
Publikováno v:
Science Translational Medicine. 14
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. The impermeable cornified layer of the stratum corneum is maintained by balancing continuous turnover driven by epidermal basal cell proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074c597e8e83b2eb94577ed9dd1e5053
https://doi.org/10.1126/scitranslmed.abp9159
https://doi.org/10.1126/scitranslmed.abp9159
Autor:
Sarah E. Headland, Hart S. Dengler, Daqi Xu, Grace Teng, Christine Everett, Rojo A. Ratsimandresy, Donghong Yan, Jing Kang, Kirthana Ganeshan, Evgeniya V. Nazarova, Sarah Gierke, Christopher J. Wedeles, Riccardo Guidi, Daryle J. DePianto, Katrina B. Morshead, Alison Huynh, Jessica Mills, Sean Flanagan, Shannon Hambro, Victor Nunez, Joanna E. Klementowicz, Yongchang Shi, Jianyong Wang, Jack Bevers, Vladimir Ramirez-Carrozzi, Rajita Pappu, Alex Abbas, Jason Vander Heiden, David F. Choy, Rajbharan Yadav, Zora Modrusan, Reynold A. Panettieri, Cynthia Koziol-White, William F. Jester, Brendan J. Jenkins, Yi Cao, Christine Clarke, Cary Austin, Daniel Lafkas, Min Xu, Paul J. Wolters, Joseph R. Arron, Nathaniel R. West, Mark S. Wilson
Publikováno v:
Science translational medicine. 14(627)
Exacerbations of symptoms represent an unmet need for people with asthma. Bacterial dysbiosis and opportunistic bacterial infections have been observed in, and may contribute to, more severe asthma. However, the molecular mechanisms driving these exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46323ac4e1c7c49de3c9a3a4fd365072
https://pubmed.ncbi.nlm.nih.gov/35110748
https://pubmed.ncbi.nlm.nih.gov/35110748
Autor:
Ena Ladi, Matthew R. Durk, Craig Stivala, Michael Blaesse, Malcolm P. Huestis, Seth F. Harris, Daniels Blake, Christine Everett, Rajita Pappu, Stefan Steinbacher, Martin Augustin, Steven T. Staben, Michael Siu, Hans E. Purkey, Celine Eidenschenk
Publikováno v:
Journal of Medicinal Chemistry. 62:7032-7041
The pan-proteasome inhibitor bortezomib demonstrated clinical efficacy in off-label trials of Systemic Lupus Erythematosus. One potential mechanism of this clinical benefit is from the depletion of pathogenic immune cells (plasmablasts and plasmacyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3714c93322d7d7c47334f2c0ee7068e0
https://doi.org/10.1021/acs.jmedchem.9b00509
https://doi.org/10.1021/acs.jmedchem.9b00509
Autor:
Wenjun Ouyang, Arivazhagan Sambandam, Rajita Pappu, Nadia Martinez-Martin, Jason A. Hackney, Vladimir Ramirez-Carrozzi, Kit Wong, Naruhisa Ota
Publikováno v:
The Journal of Immunology. 202:1935-1941
IL-17 family cytokines are critical to host defense responses at cutaneous and mucosal surfaces. Whereas IL-17A, IL-17F, and IL-17C induce overlapping inflammatory cascades to promote neutrophil-mediated immunity, IL-17E/IL-25 drives type 2 immune pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8d5c74700e14d007530f988a985df1
https://doi.org/10.4049/jimmunol.1800696
https://doi.org/10.4049/jimmunol.1800696
Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial
Autor:
Dorothy Cheung, Weily Soong, Steven G. Kelsen, Xiaoying Yang, Rajita Pappu, David F. Choy, Elliot Israel, Geoffrey Chupp, Christopher E. Brightling, Tracy Staton, Alice Fong, Michael J. Dolton, Ajit Dash, Ioana Agache, Wiebke Theess
Publikováno v:
The Journal of allergy and clinical immunology. 148(3)
Background The IL-33/ST2 pathway is linked with asthma susceptibility. Inhaled allergens, pollutants, and respiratory viruses, which trigger asthma exacerbations, induce release of IL-33, an epithelial-derived “alarmin.” Astegolimab, a human IgG2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb6a51aa3047a982bc801f6903e7bec
https://pubmed.ncbi.nlm.nih.gov/34310926
https://pubmed.ncbi.nlm.nih.gov/34310926
Autor:
Lucinda Tam, Annemarie Lekkerkerker, Jeffrey Eastham-Anderson, Melanie Domeyer, Brent S. McKenzie, Azadeh Hadadianpour, Eugene Varfolomeev, Arna Katewa, Steven Do, A. Francesca Setiadi, Wyne P. Lee, Joy Drobnick, Andres Paler-Martinez, Rajita Pappu, Katherine Bao, Marian C. Bryan, Alfred Wong, James J. Crawford, Cesar A. Corzo, Vida Asghari, Sha Klabunde, Vladimir Ramirez-Carrozi, Jodie Pang, Jason A. Hackney, Hans Brightbill, Christopher Dela Cruz, Ross Francis, Yonglian Sun, Merone Roose-Girma, Claire Emson, Wendy B. Young, Michael J. Townsend, James R. Kiefer, Cary D. Austin, Swathi Sujatha-Bhaskar, Emily Hunley, Nico Ghilardi, Daqi Xu, Søren Warming, Kate Senger, Zhiyu Huang, Vivian W. C. Lau, Domagoj Vucic, Ali A. Zarrin, Eric Suto
Publikováno v:
Science signaling. 13(634)
The dysregulation of multiple signaling pathways, including those through endosomal Toll-like receptors (TLRs), Fc gamma receptors (FcγR), and antigen receptors in B cells (BCR), promote an autoinflammatory loop in systemic lupus erythematosus (SLE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df56c99041e31c3d42be9d115b0561d
https://pubmed.ncbi.nlm.nih.gov/32487715
https://pubmed.ncbi.nlm.nih.gov/32487715
Publikováno v:
Annual review of immunology. 38
Since the birth of biotechnology, hundreds of biotherapeutics have been developed and approved by the US Food and Drug Administration (FDA) for human use. These novel medicines not only bring significant benefit to patients but also represent precisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0187e16ad7a2efd934b19c6c196b36b0
https://pubmed.ncbi.nlm.nih.gov/32340579
https://pubmed.ncbi.nlm.nih.gov/32340579
Autor:
Alexander R. Abbas, Brian L. Yaspan, Fang Cai, Jens Reeder, John G. Matthews, David F. Choy, Joseph Lin, Diana Chang, Bill Forrest, Tracy Staton, Art Wuster, Timothy W. Behrens, Cecile T.J. Holweg, Kiran Mukhyala, Tangsheng Yi, Lorena Riol Blanco, Tushar Bhangale, Matt Brauer, Rajita Pappu, Daniel Lafkas, Amy Cowgill, Julie Olsson, Joseph R. Arron, Amy Dressen, Hubert Chen, Julie Hunkapiller, Karen Cuenco, Dorothy Cheung, Jennifer Tom, Robert R. Graham, Zia Khan, Mark S. Wilson, Rebecca N. Bauer, Jan Vogel
Publikováno v:
Genes and environment.
Introduction: Genome-wide association studies (GWAS) have discovered >30 loci associated with asthma risk. Despite the characterization of asthma as a heterogeneous disorder, most GWAS evaluate asthmatics as a single population. To explore whether ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::085d86fd2e25be637fd303f884b69d93
https://doi.org/10.1183/13993003.congress-2018.oa2194
https://doi.org/10.1183/13993003.congress-2018.oa2194