Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Rajinder N. Puri"'
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 282:G461-G469
Effect of ANG II was investigated in in vitro smooth muscle strips and in isolated smooth muscle cells (SMC). Among different species, rat internal and sphincter (IAS) smooth muscle showed significant and reproducible contraction that remained unmodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52024361a06aae95a17018bad0b4134f
https://doi.org/10.1152/ajpgi.00207.2001
https://doi.org/10.1152/ajpgi.00207.2001
Publikováno v:
Life Sciences. 70:2147-2164
Studies were performed to compare the actions of Ang II in the internal anal sphincter (IAS) vs. lower esophageal sphincter (LES) smooth muscles in vitro, in opossum and rabbit. Studies also were carried out in isolated smooth muscle cells. In opossu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6120a071dfb2c6ea1b169a1daead40
https://doi.org/10.1016/s0024-3205(01)01527-2
https://doi.org/10.1016/s0024-3205(01)01527-2
Autor:
Rajinder N. Puri
Publikováno v:
Biochemical Pharmacology. 57:851-859
ADP is the oldest and one of the most important agonists of platelet activation. ADP induces platelet shape change, exposure of fibrinogen binding sites, aggregation, and influx and intracellular mobilization of Ca2+. ADP-induced platelet aggregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ba6f5a7f00d63cd19b6317a59692ec5
https://doi.org/10.1016/s0006-2952(98)00310-4
https://doi.org/10.1016/s0006-2952(98)00310-4
Autor:
Rajinder N. Puri, Robert W. Colman
Publikováno v:
Journal of Protein Chemistry. 17:429-451
Platelet aggregation is important for maintaining normal hemostasis. However, aberrant platelet aggregation plays a major role in acute coronary artery diseases, myocardial infarction, unstable angina, and stroke. ADP is one of the earliest and most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9e27dab0fe71e6b9febf1262f10ceb
https://doi.org/10.1023/a:1022518501492
https://doi.org/10.1023/a:1022518501492
Autor:
Rajinder N. Puri, Robert W. Colman
Publikováno v:
Archives of Biochemistry and Biophysics. 347:263-270
The ADP-receptor on the surface of human platelets and cells of megakaryocytic lineage has been classified as P2T purinergic receptor for which ADP is an agonist and ATP is an antagonist. Although it is one of the earliest identified of the important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0423a3881914d25836752b828c92e3f5
https://doi.org/10.1006/abbi.1997.0363
https://doi.org/10.1006/abbi.1997.0363
Publikováno v:
Archives of Biochemistry and Biophysics. 343:140-145
The 2-substituted ADP derivatives are known to activate human blood platelets with varying degrees of potency. For example, 2-(4-bromo-2,3-dioxobutylthio)adenosine-5'-diphosphate [2-BDB-TADP], an ADP-affinity analog, was previously shown by us to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c8347cc832c03b732634f3fd07803d
https://doi.org/10.1006/abbi.1997.0160
https://doi.org/10.1006/abbi.1997.0160
Publikováno v:
Journal of Biological Chemistry. 270:24482-24488
ADP is an important platelet agonist which initiates platelet shape change, aggregation, exposure of fibrinogen receptors, and calcium mobilization. Because of the limitations of previously used affinity analogs and photo-labeling studies as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69196ff7570bdcfb4ebaba5f4b18532
https://doi.org/10.1074/jbc.270.41.24482
https://doi.org/10.1074/jbc.270.41.24482
Autor:
Rajinder N. Puri, Robert W. Colman
Publikováno v:
Archives of Biochemistry and Biophysics. 286:419-427
Platelets play a major role in the hemostatic process following vascular injury. Chemical modification of cysteine and/or lysine residues in platelet proteins has been shown to cause loss of platelet aggregation induced by diverse agonists; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cc1212d255e63d16d30d805ca2f30b
https://doi.org/10.1016/0003-9861(91)90060-v
https://doi.org/10.1016/0003-9861(91)90060-v
Publikováno v:
Blood. 77:500-507
In this study we show that high molecular weight kininogen (HK) inhibited alpha-thrombin-induced aggregation of human platelets in a dose-dependent manner with complete inhibition occurring at plasma concentration (0.67 mumol/L) of HK. HK (0.67 mumol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8fc6649a02c24c54b8bd6ea2a6f6004
https://doi.org/10.1182/blood.v77.3.500.500
https://doi.org/10.1182/blood.v77.3.500.500
Publikováno v:
Chemistry Letters. 19:191-194
We have employed a recently described affinity labeling approach using S-(3-nitro-2-pyridinesulfenyl) group (Npys) to devise unique inhibitors of the Ca++-dependent thiol protease, calpain. Compounds with Npys group bound on the peptides with Leu-Leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9845380ea90e5c9475921bc1311abfdc
https://doi.org/10.1246/cl.1990.191
https://doi.org/10.1246/cl.1990.191