Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Rajinder K. Dawra"'
Autor:
Ejas Palathingal Bava, John George, Mohammad Tarique, Srikanth Iyer, Preeti Sahay, Beatriz Gomez Aguilar, Dujon B. Edwards, Bhuwan Giri, Vrishketan Sethi, Tejeshwar Jain, Prateek Sharma, Utpreksha Vaish, Harrys K. C. Jacob, Anthony Ferrantella, Craig L. Maynard, Ashok K. Saluja, Rajinder K. Dawra, Vikas Dudeja
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Despite decades of research, there is no specific therapy for acute pancreatitis (AP). In the current study, we have evaluated the efficacy of pirfenidone, an antiinflammatory and antifibrotic agent that is approved by the FDA for treatment of idiopa
Externí odkaz:
https://doaj.org/article/5a67edc6225d42e6a846bf7637ca2d15
Autor:
Ejas Palathingal Bava, John George, Srikanth Iyer, Preeti Sahay, Mohammad Tarique, Tejeshwar Jain, Utpreksha Vaish, Bhuwan Giri, Prateek Sharma, Ashok K. Saluja, Rajinder K. Dawra, Vikas Dudeja
Publikováno v:
Pancreatology. 22:553-563
Chronic pancreatitis (CP) is an irreversible fibro-inflammatory disease of the pancreas with no current targeted therapy. Pirfenidone, an anti-fibrotic and anti-inflammatory drug, is FDA approved for treatment of Idiopathic Pulmonary Fibrosis (IPF).
Autor:
Rohit Chugh, Ashok K. Saluja, Steven J. Skube, Mara B. Antonoff, Selwyn M. Vickers, Nameeta Mujumdar, Rajinder K. Dawra, Veena Sangwan, Vikas Dudeja
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology
Several mechanisms have evolved to ensure the survival of cells under adverse conditions. The heat shock response is one such evolutionarily conserved survival mechanism. Heat shock factor-1 (HSF1) is a transcriptional regulator of the heat shock res
Autor:
Veena Sangwan, Sulagna Banerjee, Steven J. Skube, Ashok K. Saluja, Vikas Dudeja, Kaustav Majumder, Rajinder K. Dawra, Amanda R. Oliveira, Lihua Li, Subbaya Subramanian, Rohit Chugh, Georg Beyer
Publikováno v:
Laboratory Investigation. 95:648-659
Despite significant progress in diagnostics and therapeutics, over 50 thousand patients die from colorectal cancer annually. Hence, there is urgent need for new lines of treatment. Triptolide, a natural compound isolated from the Chinese herb Tripter
Autor:
Klearchos K. Papas, Subbiah Pugazhenthi, Zhiguang Guo, Appakalai N. Balamurugan, Alexander C. Wiseman, Gopalakrishnan Loganathan, Sajjad M. Soltani, Ashok K. Saluja, Rajinder K. Dawra, Mark A. Sanders, Bernhard J. Hering, Kumaravel Velayutham, David E.R. Sutherland
Publikováno v:
Transplantation. 92:1222-1230
Pancreatic acinar cells are commonly cotransplanted along with islets during auto- and allotransplantations. The aims of this study were to identify how acinar cell proteases cause human islet cell loss before and after transplantation of impure isle
Autor:
Rohit Chugh, Mara B. Antonoff, Selwyn M. Vickers, Veena Sangwan, T.N. MacKenzie, Vikas Dudeja, Daniel Borja-Cacho, Nameeta Mujumdar, Rajinder K. Dawra, Ashok K. Saluja
Publikováno v:
Gastroenterology. 139:598-608
Background & Aims Pancreatic adenocarcinoma, among the most lethal human malignancies, is resistant to current chemotherapies. We previously showed that triptolide inhibits the growth of pancreatic cancer cells in vitro and prevents tumor growth in v
Autor:
Rohit Chugh, Vikas Dudeja, Kimberly A. Clawson, Selwyn M. Vickers, Nameeta Mujumdar, Rajinder K. Dawra, Y. Yokoyama, Daniel Borja-Cacho, Ashok K. Saluja
Publikováno v:
Journal of Gastrointestinal Surgery. 14:252-260
An emerging therapy in oncology is the induction of apoptotic cell death through anti-death receptor therapy. However, pancreatic cancer is resistant to apoptosis including anti-death receptor therapy. We have previously described how triptolide decr
Autor:
R. Sharif, Rajinder K. Dawra, Karen R. Wasiluk, Evelyn A. Kurt-Jones, Robert W. Finberg, Vikas Dudeja, Phoebe A. Phillips, Ashok K. Saluja
Publikováno v:
Gut. 58:813-819
Background and Aims: Acute pancreatitis is an inflammatory disease involving acinar cell injury, and the rapid production and release of inflammatory cytokines, which play a dominant role in local pancreatic inflammation and systemic complications. T
Autor:
Yang Sha Ku, Rajinder K. Dawra, D. Dhaulakhandi, Ashok K. Saluja, Vikas Dudeja, Phoebe A. Phillips, R. Sharif
Publikováno v:
Pancreas. 37:62-68
OBJECTIVES This study was undertaken to examine the cause of variation in determined values of myeloperoxidase activity from sequestered neutrophils in pancreas and lungs during pancreatitis and to develop a reproducible method for the extraction and
Publikováno v:
Journal of Cellular Physiology. 215:37-46
Heat shock proteins (HSPs), induced by a variety of stresses, are known to protect against cellular injury. Recent studies have demonstrated that prior beta-adrenergic stimulation as well as thermal or culture stress induces HSP70 expression and prot