Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Rajindar S, Sohal"'
Autor:
Michael J. Forster, Rajindar S. Sohal
Publikováno v:
Free Radical Biology and Medicine. 73:366-382
The main objective of this review is to provide an appraisal of the current status of the relationship between energy intake and the life span of animals. The concept that a reduction in food intake, or caloric restriction (CR), retards the aging pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444479d273dcf333c7cc489e0fd22f0d
Publikováno v:
Free Radical Biology and Medicine. 49:2028-2031
The simultaneous overexpression of multiple copies of Mn superoxide dismutase (SOD) and ectopic catalase (mtCat) transgenes in the mitochondria of the fruit fly, Drosophila melanogaster, was shown previously to diminish the life span. The hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2b29a909e3261cf88c7eb28ae5ddff
https://doi.org/10.1016/j.freeradbiomed.2010.09.029
https://doi.org/10.1016/j.freeradbiomed.2010.09.029
Autor:
Barbara H. Sohal, Vladimir I. Klichko, Rajindar S. Sohal, William C. Orr, Katarzyna Michalak, Svetlana N. Radyuk, Judith Benes, Igor Rebrin
Publikováno v:
Free Radical Biology and Medicine. 49:1892-1902
Drosophila mitochondria contain two peroxidases, peroxiredoxin 3 (dPrx3) and peroxiredoxin 5 (dPrx5), which together constitute the sole known intramitochondrial mechanism for the catalytic removal of hydrogen and organic peroxides. dPrx3 exists excl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae386aa2057701ef2994a12b2eaa1e2
https://doi.org/10.1016/j.freeradbiomed.2010.09.014
https://doi.org/10.1016/j.freeradbiomed.2010.09.014
Publikováno v:
Biochemical and Biophysical Research Communications. 401:64-68
The hypothesis, that structural deterioration of cytochrome c oxidase (CcO) is a causal factor in the age-related decline in mitochondrial respiratory activity and an increase in H₂O₂ generation, was tested in Drosophila melanogaster. CcO activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c54bc468035caba5f10096bd34267d7
https://doi.org/10.1016/j.bbrc.2010.09.009
https://doi.org/10.1016/j.bbrc.2010.09.009
Publikováno v:
The Journal of Nutrition. 139:1926-1932
Coenzyme Q(10) (CoQ(10)) is widely consumed as a dietary supplement to enhance bioenergetic capacity and to ameliorate the debilitative effects of the aging process or certain pathological conditions. Our main purpose in this study was to determine w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71f7b9c37583a2eb6a5e02e2ce06a06
https://doi.org/10.3945/jn.109.110437
https://doi.org/10.3945/jn.109.110437
Autor:
Katarzyna Michalak, Vladimir I. Klichko, Svetlana N. Radyuk, Rajindar S. Sohal, Judith Benes, William C. Orr, Igor Rebrin
Publikováno v:
Biochemical Journal. 419:437-445
Peroxiredoxin 5 is a distinct isoform of the peroxiredoxin gene family. The antioxidative and anti-apoptotic functions of peroxiredoxin 5 have been extensively demonstrated in cell culture experiments. In the present paper, we provide the first funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd63b1955c03400b16e2772749803f7
https://doi.org/10.1042/bj20082003
https://doi.org/10.1042/bj20082003
Publikováno v:
The Journal of Nutrition. 139:533-539
In this study, our main objective was to determine whether energy restriction (ER) affects the rate of oxygen consumption of mice transiently or lastingly and whether metabolic rate plays a role in the ER-related extension of life span. We compared r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca23a82c094071d97946ffb974c7c06
https://doi.org/10.3945/jn.108.100313
https://doi.org/10.3945/jn.108.100313
Autor:
Katarzyna Michalak, Svetlana N. Radyuk, Vladimir I. Klichko, James M. Luchak, Rajindar S. Sohal, William C. Orr, Igor Rebrin
Publikováno v:
Journal of Biological Chemistry. 284:2266-2274
GSH concentration is considerably lower in the nucleus than in the cytoplasm; however, it is significantly elevated during active cell proliferation. The main purpose of this study was to understand the mechanism underlying these variations in nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5926bc0b8f11fcc94e2a3cfeda3915f
https://doi.org/10.1074/jbc.m805913200
https://doi.org/10.1074/jbc.m805913200
Autor:
Igor Rebrin, Rajindar S. Sohal
Publikováno v:
Advanced Drug Delivery Reviews. 60:1545-1552
The GSH:GSSG ratio, which is the primary determinant of the cellular redox state, becomes progressively more pro-oxidizing during the aging process due to an elevation in the GSSG content and a decline in the ability for de novo GSH biosynthesis. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8f519b794017736b6c6cd72628d074
https://doi.org/10.1016/j.addr.2008.06.001
https://doi.org/10.1016/j.addr.2008.06.001
Publikováno v:
Mechanisms of Ageing and Development. 129:558-561
A key feature of the aging process is that the mitochondrial respiratory capacity declines and production of reactive oxygen species increases in the later part of life span. In previous studies, cytochrome c oxidase (CcO), the terminal component of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f34d9acab3016d16fa0a5938afa07c
https://doi.org/10.1016/j.mad.2008.04.006
https://doi.org/10.1016/j.mad.2008.04.006