Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Rajikala Suganthan"'
Autor:
Gunn A. Hildrestrand, Veslemøy Rolseth, Nicolas Kunath, Rajikala Suganthan, Vidar Jensen, Anna M. Bugaj, Marion S. Fernandez-Berrocal, Sunniva B. Sikko, Susanne Vetlesen, Anna Kuśnierczyk, Ann-Karin Olsen, Kristine B. Gützkow, Alexander D. Rowe, Wei Wang, Olve Moldestad, Monica D. Syrstad, Geir Slupphaug, Lars Eide, Arne Klungland, Pål Sætrom, Luisa Luna, Jing Ye, Katja Scheffler, Magnar Bjørås
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Gunn Hildrestrand, Veslemøy Rolseth, and Nicolas Kunath et al. examine mice lacking the NEIL1 and NEIL2 DNA glycosylases involved in base excision repair. Their results suggest that loss of both NEIL1 and NEIL2 dysregulates genes relevant to synapti
Externí odkaz:
https://doaj.org/article/36b704fa17dc44b1933173201d933187
Autor:
Lauritz Kennedy, Emilie R Glesaaen, Vuk Palibrk, Marco Pannone, Wei Wang, Ali Al-Jabri, Rajikala Suganthan, Niklas Meyer, Marie Landa Austbø, Xiaolin Lin, Linda H Bergersen, Magnar Bjørås, Johanne E Rinholm
Publikováno v:
eLife, Vol 11 (2022)
Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that facilitate tissue repair after HI may aid the developm
Externí odkaz:
https://doaj.org/article/cbd0ebdeffa14ea4b5e69b80e8fa4039
Autor:
Mingyi Yang, Xiaolin Lin, Filip Segers, Rajikala Suganthan, Gunn A. Hildrestrand, Johanne E. Rinholm, Per Arne Aas, Mirta M.L. Sousa, Sverre Holm, Nils Bolstad, David Warren, Rolf K. Berge, Rune F. Johansen, Arne Yndestad, Elise Kristiansen, Arne Klungland, Luisa Luna, Lars Eide, Bente Halvorsen, Pål Aukrust, Magnar Bjørås
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4165-4178.e7 (2020)
Summary: Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates decreased growt
Externí odkaz:
https://doaj.org/article/247c0649b261428588cdfcf101aa6b70
Autor:
Miaomiao Li, Xu Zhao, Wei Wang, Hailing Shi, Qingfei Pan, Zhike Lu, Sonia Peña Perez, Rajikala Suganthan, Chuan He, Magnar Bjørås, Arne Klungland
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background N 6 -methyladenosine (m6A) modification in mRNAs was recently shown to be dynamically regulated, indicating a pivotal role in multiple developmental processes. Most recently, it was shown that the Mettl3-Mettl14 writer complex of
Externí odkaz:
https://doaj.org/article/7f9dd8ef00aa417ab2066fa164af8e4a
Autor:
Veslemøy Rolseth, Luisa Luna, Ann Karin Olsen, Rajikala Suganthan, Katja Scheffler, Christine G. Neurauter, Ying Esbensen, Anna Kuśnierczyk, Gunn A. Hildrestrand, Anne Graupner, Jill M. Andersen, Geir Slupphaug, Arne Klungland, Hilde Nilsen, Magnar Bjørås
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The
Externí odkaz:
https://doaj.org/article/5c917068e02c43e0970c726380db6068
Autor:
Monica D. Bjørge, Gunn A. Hildrestrand, Katja Scheffler, Rajikala Suganthan, Veslemøy Rolseth, Anna Kuśnierczyk, Alexander D. Rowe, Cathrine B. Vågbø, Susanne Vetlesen, Lars Eide, Geir Slupphaug, Yusaku Nakabeppu, Timothy W. Bredy, Arne Klungland, Magnar Bjørås
Publikováno v:
Cell Reports, Vol 13, Iss 12, Pp 2671-2678 (2015)
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases. Ogg1−/−M
Externí odkaz:
https://doaj.org/article/4ac21c419fc4404d848fbcaac9fd6541
Autor:
Christine Elisabeth Regnell, Gunn Annette Hildrestrand, Yngve Sejersted, Tirill Medin, Olve Moldestad, Veslemøy Rolseth, Silje Zandstra Krokeide, Rajikala Suganthan, Luisa Luna, Magnar Bjørås, Linda H. Bergersen
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 503-510 (2012)
Accumulation of oxidative DNA damage has been proposed as a potential cause of age-related cognitive decline. The major pathway for removal of oxidative DNA base lesions is base excision repair, which is initiated by DNA glycosylases. In mice, Neil3
Externí odkaz:
https://doaj.org/article/2db3587bde7c4ee5a797f4931f5d4fc3
Autor:
Magnar Bjørås, Pål Aukrust, Bente Halvorsen, Jonas Øgaard, Erik A.L. Biessen, Filip M. Segers, Martin R. Bennett, Eric P. van der Veer, Helle F. Jørgensen, Katja Scheffler, Ellen Lund Sagen, Sverre Holm, Ståle Nygård, Vigdis Bjerkeli, Kirsten B. Holven, Jurriën Prins, Tuula A. Nyman, Xiang Yi Kong, Knut H. Lauritzen, Tuva B. Dahl, Hilde Nilsen, Tom Rune Karlsen, Kuan Yang, Ana Quiles-Jiménez, Penelope Kroustallaki, Yngvar Fløisand, Maria Belland Olsen, Tonje Skarpengland, Rajikala Suganthan, Ida Gregersen
Publikováno v:
Atherosclerosis, 324, 123-132. Elsevier Ireland Ltd
Atherosclerosis
Atherosclerosis
Background and aims: Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously been shown to have a role in
Autor:
Emilie R Glesaaen, Lauritz Kennedy, Vuk Palibrk, Marco Pannone, Wei Wang, Ali Al-Jabri, Rajikala Suganthan, Niklas Meyer, Marie Landa Austbø, Xiaolin Lin, Linda H Bergersen, Magnar Bjørås, Johanne E Rinholm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a900d0dc7e5e4302a19216b5c4c5109d
https://doi.org/10.7554/elife.76451.sa2
https://doi.org/10.7554/elife.76451.sa2
Autor:
Mirta M. L. Sousa, Rolf K. Berge, Filip M. Segers, Nils Bolstad, Gunn A. Hildrestrand, Luisa Luna, Pål Aukrust, Lars Eide, Magnar Bjørås, Bente Halvorsen, Elise Kristiansen, David J. Warren, Rune F. Johansen, Johanne Egge Rinholm, Rajikala Suganthan, Sverre Holm, Per Arne Aas, Arne Klungland, Mingyi Yang, Arne Yndestad, Xiaolin Lin
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4165-4178.e7 (2020)
Cell reports
Cell reports
Summary: Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates decreased growt