Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Rajika Arora"'
Autor:
Malgorzata M. Duszczyk, Harry Wischnewski, Tamara Kazeeva, Rajika Arora, Fionna E. Loughlin, Christine von Schroetter, Ugo Pradère, Jonathan Hall, Constance Ciaudo, Frédéric H.-T. Allain
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors report an unusual mode of AU-rich RNA recognition by the RNA recognition motifs of DND1, a protein essential for germline development, in a 27.5 kDa NMR structure and provide additional insight on DND1 function from cell-based experiments
Externí odkaz:
https://doaj.org/article/e56fd6d7edc04090b57e471e350a8a05
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/1b0633f6b58d4910b2230f3e77a215dc
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Abstract Alternative Lengthening of Telomeres (ALT) is a Break-Induced Replication (BIR)-based mechanism elongating telomeres in a subset of human cancer cells. While the notion that spontaneous DNA damage at telomeres is required to initiate ALT, th
Externí odkaz:
https://doaj.org/article/bec18a68f8c74bdda25115e7a6abfbdc
Autor:
Bruno Silva, Richard Pentz, Ana Margarida Figueira, Rajika Arora, Yong Woo Lee, Charlotte Hodson, Harry Wischnewski, Andrew J. Deans, Claus M. Azzalin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
In cancer cells, telomeres can be elongated through homology directed-repair pathways in a process known as Alternative Lengthening of Telomeres (ALT). Here, the authors reveal that FANCM regulates ALT activity and ALT cell proliferation by limiting
Externí odkaz:
https://doaj.org/article/288a7c4d17534c13992012134d9710a4
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35714 (2012)
RNA polymerase II transcribes the physical ends of linear eukaryotic chromosomes into a variety of long non-coding RNA molecules including telomeric repeat-containing RNA (TERRA). Since TERRA discovery, advances have been made in the characterization
Externí odkaz:
https://doaj.org/article/538c65808f5844aebb0c6c8a8345076f
Publikováno v:
EMBO Reports, 23 (9)
LINE-1 (L1) retroelements have retained their ability to mobilize. Mechanisms regulating L1 mobility include DNA methylation in somatic cells and the piRNA pathway in the germline. During preimplantation stages of mouse embryonic development, however
LINE-1 (L1) are autonomous retroelements that have retained their ability to mobilize. Mechanisms regulating L1 mobility include DNA methylation in somatic cells and the Piwi-interacting RNA pathway in the germline. During pre-implantation stages of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8186d12f228dcd44cd855e9058de9e
https://doi.org/10.1101/2021.11.09.467897
https://doi.org/10.1101/2021.11.09.467897
Autor:
Madlen Müller, Tara Fäh, Moritz Schaefer, Victoria Hermes, Janina Luitz, Patrick Stalder, Rajika Arora, Richard Patryk Ngondo, Constance Ciaudo
Publikováno v:
Life Science Alliance, 5 (6)
Argonaute proteins (AGOs), which play an essential role in cytosolic post-transcriptional gene silencing, have been also reported to function in nuclear processes like transcriptional activation or repression, alternative splicing and, chromatin orga
Autor:
M. Schaefer, Constance Ciaudo, P. Stalder, T. Faeh, Richard Patryk Ngondo, Janina Luitz, Markus Mueller, Rajika Arora
SUMMARY In the past years, several studies reported nuclear roles for the Argonaute (AGO) proteins associating them with transcriptional activation or repression, alternative splicing and, chromatin organization. However, as most of these experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::199d6506174391ce085597e7fba6a986
https://doi.org/10.1101/2021.07.26.453733
https://doi.org/10.1101/2021.07.26.453733
Autor:
Malgorzata M, Duszczyk, Harry, Wischnewski, Tamara, Kazeeva, Rajika, Arora, Fionna E, Loughlin, Christine, von Schroetter, Ugo, Pradère, Jonathan, Hall, Constance, Ciaudo, Frédéric H-T, Allain
Publikováno v:
Nature communications. 13(1)
Dead End (DND1) is an RNA-binding protein essential for germline development through its role in post-transcriptional gene regulation. The molecular mechanisms behind selection and regulation of its targets are unknown. Here, we present the solution