Výsledky vyhledávání

Reversing Tumor Immune Suppression with Intratumoral IL-12: Activation of Tumor-Associated T Effector/Memory Cells, Induction of T Suppressor Apoptosis, and Infiltration of CD8+ T Effectors

Autor: Karanvir S. Aulakh, Raji E. Nair, Mehmet O. Kilinc, Michele M. Kosiewicz, Nejat K. Egilmez, Pascale Alard, Stacy A. Jones

Publikováno v: The Journal of Immunology. 177:6962-6973

A single intratumoral injection of IL-12 and GM-CSF-loaded slow-release microspheres induces T cell-dependent eradication of established primary and metastatic tumors in a murine lung tumor model. To determine how the delivery of cytokines directly t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a343129eb75471e4d5c598ba722870
https://doi.org/10.4049/jimmunol.177.10.6962

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IL-12 + GM-CSF Microsphere Therapy Induces Eradication of Advanced Spontaneous Tumors in her-2/neu Transgenic Mice But Fails to Achieve Long-Term Cure Due to the Inability to Maintain Effector T-Cell Activity

Autor: Atima Sharma, Nejat K. Egilmez, Edith Mathiowitz, Raji E. Nair, Yong S. Jong, Stacy A. Jones

Publikováno v: Journal of Immunotherapy. 29:10-20

A single intratumoral injection of interleukin-12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres induced the regression of advanced spontaneous mammary tumors, suppressed additional tumor development, and enhanced surv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e594a38b900b29a80835c6676fdc540
https://doi.org/10.1097/01.cji.0000175489.19314.d2

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The flavonoid, quercetin, differentially regulates Th-1 (IFNγ) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells

Autor: Madhavan Nair, Ram Chawda, Chithan C. Kandaswami, Stanley A. Schwartz, Hari Krishnan Nair, Niranjan Kumar, Supriya D. Mahajan, Kailash C. Chadha, Raji E Nair

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1593:29-36

Flavonoids are plant metabolites that are dietary antioxidants and exert significant anti-tumor, anti-allergic, anti-inflammatory and anti-viral effects. It is generally accepted that Th-1 derived cytokines such as IL-2, IFNgamma and IL-12 promote ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854552a4e7a861075fcef2ba10d428b2
https://doi.org/10.1016/s0167-4889(02)00328-2

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Isolation and Characterization of a 31 kDa Mycobacterial Antigen from Tuberculous Sera and its Identification with in vitro Released Culture Filtrate Antigen of Mtb H37Ra Bacilli

Autor: Bhaskar C Harinath, Satish Kumar, Raji E. Nair, Swati Banerjee

Publikováno v: Scandinavian Journal of Infectious Diseases. 32:551-556

Antigens released in vivo are of considerable interest in the immunodiagnosis of infectious diseases. Circulating antigen was isolated from bacteriologically confirmed tuberculous sera by ammonium sulphate precipitation. The protein fraction between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0fb310e4abbf3840d670c86d5620b0
https://doi.org/10.1080/003655400458866

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Chronic chemoimmunotherapy achieves cure of spontaneous murine mammary tumors via persistent blockade of posttherapy counter-regulation

Autor: Nejat K. Egilmez, Tao Gu, Raji E. Nair, Jamie L. Harden, Mehmet O. Kilinc, Rachael B. Rowswell-Turner

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 187(8)

Intratumoral delivery of Interleukin-12 (IL-12) and Granulocyte Macrophage Colony-stimulating Factor (GM-CSF) induces local and systemic antitumor CD8+ T-cell activation and tumor kill. The effector response however, is transient and is rapidly count

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13141b43d3279a2b180d74b8f9bcae49
https://pubmed.ncbi.nlm.nih.gov/21908736

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Chronic immune therapy induces a progressive increase in intratumoral T suppressor activity and a concurrent loss of tumor-specific CD8+ T effectors in her-2/neu transgenic mice bearing advanced spontaneous tumors

Autor: Raji E. Nair, Nejat K. Egilmez, Mehmet O. Kilinc, Stacy A. Jones

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 176(12)

A single intratumoral injection of IL-12 and GM-CSF-encapsulated microspheres induces the complete regression of advanced spontaneous tumors in her-2/neu transgenic mice. However, tumor regression in this model is transient and long-term cure is not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0722b11376474522fb68bc34240496d
https://pubmed.ncbi.nlm.nih.gov/16751376

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Characterization of cytokine-encapsulated controlled-release microsphere adjuvants

Autor: Atima Sharma, Nejat K. Egilmez, Carl M. Harper, Edith Mathiowitz, Raji E. Nair, Laura Hammer

Publikováno v: Cancer biotherapyradiopharmaceuticals. 19(6)

Controlled-release, injectable polymer microspheres provide a clinically feasible alternative to gene-modification for the local, sustained delivery of cytokines to tumors for cancer immunotherapy. Long-term release kinetics, bioactivity profiles, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0437d9ea5093f72e5ad0be0f91c962ec
https://pubmed.ncbi.nlm.nih.gov/15665625

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Akademický článek

Characterization of Cytokine-Encapsulated Controlled-Release Microsphere Adjuvants.

Autor: Atima Sharma, Carl M. Harper, Laura Hammer, Raji E. Nair, Edith Mathiowitz, Nejat K. Egilmez

Publikováno v: Cancer Biotherapy & Radiopharmaceuticals; Dec2004, Vol. 19 Issue 6, p764-769, 6p

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