Výsledky vyhledávání - "Rajić Zrinka"

Akademický článek

Synthesis, antiproliferative and antiplasmodial evaluation of new chloroquine and mefloquine-based harmiquins

Autor: Pavić Kristina, Poje Goran, Carvalho Lais Pessanha De, Held Jana, Rajić Zrinka

Publikováno v: Acta Pharmaceutica, Vol 73, Iss 4, Pp 537-558 (2023)

Here we present the synthesis and evaluation of the biological activity of new hybrid compounds, ureido-type (UT) harmiquins, based on chloroquine (CQ) or mefloquine (MQ) scaffolds and β-carboline alkaloid harmine against cancer cell lines and Plasm

Externí odkaz: https://doaj.org/article/77c07b04e47642adb8827ba2058d2429

Zobrazit plný text záznamu

Akademický článek

Antiproliferative evaluation of various aminoquinoline derivatives

Autor: Zorc Branka, Rajić Zrinka, Perković Ivana

Publikováno v: Acta Pharmaceutica, Vol 69, Iss 4, Pp 661-672 (2019)

Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adeno-carcinoma (M

Externí odkaz: https://doaj.org/article/214d5742d5284647b96e11ce6bf126d2

Zobrazit plný text záznamu

Akademický článek

Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides

Autor: Beus Maja, Fontinha Diana, Held Jana, Rajić Zrinka, Prudêncio Miguel, Zorc Branka

Publikováno v: Acta Pharmaceutica, Vol 69, Iss 2, Pp 233-248 (2019)

The paper is focused on the synthesis and screening of the antiplasmodial activity of novel fumardiamides 5–10 with the mefloquine pharmacophore and a Michael acceptor motif. Multi-step reactions leading to the title compounds included two amide bo

Externí odkaz: https://doaj.org/article/adc96e4f36284f34aa33207dd71c955c

Zobrazit plný text záznamu

Akademický článek

Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro

Autor: Pavić Kristina, Rajić Zrinka, Mlinarić Zvonimir, Uzelac Lidija, Kralj Marijeta, Zorc Branka

Publikováno v: Acta Pharmaceutica, Vol 68, Iss 4, Pp 471-483 (2018)

In the current paper, we describe the design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway

Externí odkaz: https://doaj.org/article/08c7338411dd4619a376c202b271fd37

Zobrazit plný text záznamu