Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Rajgopal Govindarajan"'
Autor:
Avinash K. Persaud, Matthew C. Bernier, Michael A. Massey, Shipra Agrawal, Tejinder Kaur, Debasis Nayak, Zhiliang Xie, Brenna Weadick, Ruchika Raj, Kasey Hill, Nicole Abbott, Arnav Joshi, Nadeen Anabtawi, Claire Bryant, Arpad Somogyi, Zobeida Cruz-Monserrate, Foued Amari, Vincenzo Coppola, Alex Sparreboom, Sharyn D. Baker, Jashvant D. Unadkat, Mitch A. Phelps, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Concentrative nucleoside transporters (CNTs) are active nucleoside influx systems, but their in vivo roles are poorly defined. By generating CNT1 knockout (KO) mice, here we identify a role of CNT1 in the renal reabsorption of nucleosides. D
Externí odkaz:
https://doaj.org/article/bab63ae328b3450a9e6f8d180eccc7bc
Autor:
Avinash K. Persaud, Matthew C. Bernier, Michael A. Massey, Shipra Agrawal, Tejinder Kaur, Debasis Nayak, Zhiliang Xie, Brenna Weadick, Ruchika Raj, Kasey Hill, Nicole Abbott, Arnav Joshi, Nadeen Anabtawi, Claire Bryant, Arpad Somogyi, Zobeida Cruz-Monserrate, Foued Amari, Vincenzo Coppola, Alex Sparreboom, Sharyn D. Baker, Jashvant D. Unadkat, Mitch A. Phelps, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/2b638685a878448bb21750b2e6773983
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Adriamycin (ADR)-induced nephropathy remains the leading model to study human primary focal segmental glomerulosclerosis (FSGS), a common pathway for podocyte damage and glomerular loss of function that leads to chronic kidney disease. However, the u
Externí odkaz:
https://doaj.org/article/051419071ecb49c28e32f51382a70f58
Autor:
Debasis Nayak, Brenna Weadick, Avinash K. Persaud, Radhika Raj, Reena Shakya, Junan Li, Moray J. Campbell, Rajgopal Govindarajan
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104193- (2022)
Summary: The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells
Externí odkaz:
https://doaj.org/article/7f4a4a2d3e4b42b5a8bce96353c443e8
Autor:
Avinash K. Persaud, Sreenath Nair, Md Fazlur Rahman, Radhika Raj, Brenna Weadick, Debasis Nayak, Craig McElroy, Muruganandan Shanmugam, Sue Knoblaugh, Xiaolin Cheng, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Mutations in ENT3, encoded by SLC29A3, result in anaemia and erythroid hypoplasia, suggesting roles in erythropoiesis. Here the authors show that ENT3 acts as a lysosomal bile acid transporter, and mutation compromises taurine conjugated bile acid tr
Externí odkaz:
https://doaj.org/article/087a41082d3d4e2c8dbfb1af03cf1a8b
Autor:
Claire Bryant, Galen Rask, Amanda P. Waller, Amy Webb, Marina R. Galdino-Pitta, Angelica A. Amato, Rachel Cianciolo, Rajgopal Govindarajan, Brian Becknell, Bryce A. Kerlin, Francisco A.R. Neves, Alessia Fornoni, Shipra Agrawal
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104001- (2022)
Summary: Glomerular disease manifests as nephrotic syndrome (NS) with high proteinuria and comorbidities, and is frequently refractory to standard treatments. We hypothesized that a selective modulator of PPARγ, GQ-16, will provide therapeutic advan
Externí odkaz:
https://doaj.org/article/44c5e6b650c949c28445ae97cc0f1fae
Autor:
Ji Young Kim, Yuntao Bai, Laura A. Jayne, Ralph D. Hector, Avinash K. Persaud, Su Sien Ong, Shreshtha Rojesh, Radhika Raj, Mei Ji He Ho Feng, Sangwoon Chung, Rachel E. Cianciolo, John W. Christman, Moray J. Campbell, David S. Gardner, Sharyn D. Baker, Alex Sparreboom, Rajgopal Govindarajan, Harpreet Singh, Taosheng Chen, Ming Poi, Katalin Susztak, Stuart R. Cobb, Navjot Singh Pabla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a S
Externí odkaz:
https://doaj.org/article/f36413dcdc0f4c47bbdac00ac1a34b20
Autor:
Claire Bryant, Amy Webb, Alexander S. Banks, Dawn Chandler, Rajgopal Govindarajan, Shipra Agrawal
Publikováno v:
Cells, Vol 11, Iss 21, p 3455 (2022)
Podocytes are highly differentiated epithelial cells, and their structural and functional integrity is compromised in a majority of glomerular and renal diseases, leading to proteinuria, chronic kidney disease, and kidney failure. Traditional agonist
Externí odkaz:
https://doaj.org/article/74585e641d8d4d3489e56e7a313b64b4
Autor:
Sreenath Nair, Anne M. Strohecker, Avinash K. Persaud, Bhawana Bissa, Shanmugam Muruganandan, Craig McElroy, Rakesh Pathak, Michelle Williams, Radhika Raj, Amal Kaddoumi, Alex Sparreboom, Aaron M. Beedle, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misreg
Externí odkaz:
https://doaj.org/article/808693518ee945b095baa8826e112354
Autor:
Syed Saqib Ali, Ruchika Raj, Tejinder Kaur, Brenna Weadick, Debasis Nayak, Minnsung No, Jane Protos, Hannah Odom, Kajal Desai, Avinash K. Persaud, Joanne Wang, Rajgopal Govindarajan
Publikováno v:
Cancers, Vol 14, Iss 13, p 3113 (2022)
Anticancer nucleoside analogs produce adverse, and at times, dose-limiting hematological toxicities that can compromise treatment efficacy, yet the mechanisms of such toxicities are poorly understood. Recently, cellular nucleoside transport has been
Externí odkaz:
https://doaj.org/article/8ce329d569a54bfdabbdf845457f9b69