Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Rajeshwar R, Tekmal"'
Autor:
Behnam Ebrahimi, Suryavathi Viswanadhapalli, Uday P. Pratap, Gopalam Rahul, Xue Yang, Prabhakar Pitta Venkata, Viktor Drel, Bindu Santhamma, Swapna Konda, Xiaonan Li, Alondra Lee Rodriguez Sanchez, Hui Yan, Gangadhara R. Sareddy, Zhenming Xu, Brij B. Singh, Philip T. Valente, Yidong Chen, Zhao Lai, Manjeet Rao, Edward R. Kost, Tyler Curiel, Rajeshwar R. Tekmal, Hareesh B. Nair, Ratna K. Vadlamudi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-18 (2024)
Abstract Of all gynecologic cancers, epithelial-ovarian cancer (OCa) stands out with the highest mortality rates. Despite all efforts, 90% of individuals who receive standard surgical and cytotoxic therapy experience disease recurrence. The precise m
Externí odkaz:
https://doaj.org/article/9ac36726d5db494b89c1884b726a9b5c
Autor:
Zexuan Liu, Junhao Liu, Behnam Ebrahimi, Uday P. Pratap, Yi He, Kristin A. Altwegg, Weiwei Tang, Xiaonan Li, Zhao Lai, Yidong Chen, Liangfang Shen, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Rajeshwar R. Tekmal, Manjeet K. Rao, Ratna K. Vadlamudi
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-18 (2022)
Abstract Background Methyltransferase SETDB1 is highly expressed in breast cancer (BC), however, the mechanisms by which SETDB1 promotes BC progression to endocrine therapy resistance remains elusive. In this study, we examined the mechanisms by whic
Externí odkaz:
https://doaj.org/article/9e4da8bdd334483492d30abd1b8a15f8
Autor:
Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrahimi, Hui Yan, Yi Zou, Swapna Konda, Gangadhara R. Sareddy, Zhenming Xu, Yidong Chen, Manjeet K. Rao, Andrew J. Brenner, Virginia G. Kaklamani, Rajeshwar R. Tekmal, Gulzar Ahmed, Ganesh V. Raj, Klaus J. Nickisch, Hareesh B. Nair, Ratna K. Vadlamudi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Li, Viswanadhapalli et al utilized multiple in vitro, ex vivo and in vivo models of TNBC to investigate LIFR inhibition. The authors reported that HDAC inhibition in TNBC cells led to an increase of LIFR expression and over activation of the downstre
Externí odkaz:
https://doaj.org/article/8b39ff553a7a47e7a5a926087847574b
Autor:
Weiwei Tang, Kumaraguruparan Ramasamy, Sureshkumar M. A. Pillai, Bindu Santhamma, Swapna Konda, Prabhakar Pitta Venkata, Logan Blankenship, Junhao Liu, Zexuan Liu, Kristin A. Altwegg, Behnam Ebrahimi, Uday P. Pratap, Xiaonan Li, Philip T. Valente, Edward Kost, Gangadhara R. Sareddy, Ratna K. Vadlamudi, Hareesh B. Nair, Rajeshwar R. Tekmal, Suryavathi Viswanadhapalli
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Endometrial cancer (EC) is the fourth most common cancer in women. Advanced-stage EC has limited treatment options with a poor prognosis. There is an unmet need for the identification of actionable drivers for the development of targeted the
Externí odkaz:
https://doaj.org/article/1cfca25be46f4749a68da61a6d728416
Autor:
Jing Wang, Uday P. Pratap, Yujiao Lu, Gangadhara R. Sareddy, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Darrell W. Brann
Publikováno v:
Biology, Vol 12, Iss 4, p 621 (2023)
17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for studying brain-derived E2 include global and conditional non-inducible knockout mouse models. The
Externí odkaz:
https://doaj.org/article/cff05b2120cb4290a8c54df218d5d04e
Autor:
Darrell W. Brann, Yujiao Lu, Jing Wang, Gangadhara R. Sareddy, Uday P. Pratap, Quanguang Zhang, Rajeshwar R. Tekmal, Ratna K. Vadlamudi
Publikováno v:
Biology, Vol 11, Iss 12, p 1698 (2022)
Astrocytes and neurons in the male and female brains produce the neurosteroid brain-derived 17β-estradiol (BDE2) from androgen precursors. In this review, we discuss evidence that suggest BDE2 has a role in a number of neurological conditions, such
Externí odkaz:
https://doaj.org/article/ea2a70e4f3d94b66b6a13b433d57e23e
Autor:
Logan Blankenship, Uday P. Pratap, Xue Yang, Zexuan Liu, Kristin A. Altwegg, Bindu Santhamma, Kumaraguruparan Ramasamy, Swapna Konda, Yidong Chen, Zhao Lai, Siyuan Zheng, Gangadhara R. Sareddy, Philip T. Valente, Edward R. Kost, Hareesh B. Nair, Rajeshwar R. Tekmal, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli
Publikováno v:
Cancers, Vol 14, Iss 21, p 5400 (2022)
Endometrial cancer (EC) is the fourth most common cancer in women, and half of the endometrioid EC (EEC) cases are attributable to obesity. However, the underlying mechanism(s) of obesity-driven EEC remain(s) unclear. In this study, we examined wheth
Externí odkaz:
https://doaj.org/article/45035a5f0a6e463586f4b34d39831afc
Autor:
Yi He, Salvador Alejo, Prabhakar Pitta Venkata, Jessica D. Johnson, Ilanna Loeffel, Uday P. Pratap, Yi Zou, Zhao Lai, Rajeshwar R. Tekmal, Edward R. Kost, Gangadhara R. Sareddy
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7159 (2022)
Ovarian cancer (OCa) is the deadliest gynecologic cancer. Emerging studies suggest ovarian cancer stem cells (OCSCs) contribute to chemotherapy resistance and tumor relapse. Recent studies demonstrated estrogen receptor beta (ERβ) exerts tumor suppr
Externí odkaz:
https://doaj.org/article/a380bb36baab4e2390b376a9e69df72e
Autor:
Darrell W. Brann, Yujiao Lu, Jing Wang, Gangadhara R. Sareddy, Uday P. Pratap, Quanguang Zhang, Rajeshwar R. Tekmal, Ratna K. Vadlamudi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13242 (2021)
In addition to being a steroid hormone, 17β-estradiol (E2) is also a neurosteroid produced in neurons in various regions of the brain of many species, including humans. Neuron-derived E2 (NDE2) is synthesized from androgen precursors via the action
Externí odkaz:
https://doaj.org/article/60cf628f2a8f4b56b31d719a324fe38e
Autor:
Ratna K. Vadlamudi, LuZhe Sun, Rajeshwar R. Tekmal, Ganesh V. Raj, Jung-Mo Ahn, Abhik Bandyopadhyay, Keya De Mukhopadhyay, Valerie Cortez, Dimple Chakravarty, Sudipa Roy
PDF file - 648KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65df67d20b69414663021705d88d7679
https://doi.org/10.1158/1541-7786.22517169
https://doi.org/10.1158/1541-7786.22517169