Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Rajeshwar Narlawar"'
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 8, Pp o1885-o1885 (2011)
In the title compound, C21H20O4, the central heptatrienone unit is approximately planar, with a maximum atomic deviation of 0.1121 (11) Å; the two benzene rings are twisted with respect to the heptatrienone mean plane by 2.73 (5) and 29.31 (4)°. Th
Externí odkaz:
https://doaj.org/article/daea0d90c3114d3e92b11968a7799c0e
Autor:
Lutgarde Serneels, Rajeshwar Narlawar, Laura Perez Benito, Marti Municoy, Victor Guallar, Dries T’Syen, Maarten Dewilde, François Bischoff, Erwin Fraiponts, Gary Tresadern, Peter W.M. Roevens, Harrie J.M. Gijsen, Bart De Strooper
Clinical development of γ-secretases, a family of intramembrane cleaving proteases, as therapeutic targets for a variety of disorders including cancer and Alzheimer's disease was aborted because of serious mechanism-based side effects in the phase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34173e9b72a677f8f8c9ec51792ad684
https://lirias.kuleuven.be/handle/20.500.12942/719766
https://lirias.kuleuven.be/handle/20.500.12942/719766
Autor:
Michael Kassiou, Louis M. Rendina, Anna Pawlik, Agnieszka Pyrczak-Felczykowska, Kamil Ryś, Anna Herman-Antosiewicz, Rajeshwar Narlawar, Beata Guzow-Krzemińska, Aleksandra Hać, Tristan A. Reekie, Damian Artymiuk
Publikováno v:
Journal of Natural Products. 83:563-564
Autor:
Soma Vignarajan, David E. Hibbs, Anuradha Kumari, Rajeshwar Narlawar, Vivian W.Y. Liao, Dulal Panda, Paul W. Groundwater
Publikováno v:
Molecular pharmacology. 97(6)
The microtubule-binding taxanes, docetaxel and cabazitaxel, are administered intravenously for the treatment of castration-resistant prostate cancer (CRPC) as the oral administration of these drugs is largely hampered by their low and highly variable
Autor:
Jan Cools, Inge Lodewijckx, David Nittner, Tom Taghon, Rajeshwar Narlawar, Roger Habets, James Dooley, Adrian Liston, Bart De Strooper, Sofie Demeyer, Delphine Verbeke, Charles E. de Bock, Lutgarde Serneels
Publikováno v:
Science Translational Medicine. 11
Given the high frequency of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-ALL), inhibition of the γ-secretase complex remains an attractive target to prevent ligand-independent release of the cytoplasmic tail and oncogenic NO
Autor:
Beata Guzow-Krzemińska, Agnieszka Pyrczak-Felczykowska, Michael Kassiou, Anna Pawlik, Anna Herman-Antosiewicz, Louis M. Rendina, Rajeshwar Narlawar, Aleksandra Hać, Damian Artymiuk, Kamil Ryś, Tristan A. Reekie
Publikováno v:
Journal of Natural Products
Usnic acid is a secondary metabolite abundantly found in lichens, for which promising cytotoxic and antitumor potential has been shown. However, knowledge concerning activities of its derivatives is limited. Herein, a series of usnic acid derivatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42ee3570d19585e5d25ddcb5fbc4d0e
https://hdl.handle.net/2123/24771
https://hdl.handle.net/2123/24771
Remarkable Enhancement in Boron Uptake Within Glioblastoma Cells With Carboranyl–Indole Carboxamides
Autor:
Michael Kassiou, Eryn L. Werry, Eleonora Da Pozzo, Christopher J.D. Austin, Silvia Selleri, Claudia Martini, Jan Kahlert, Rajeshwar Narlawar, Louis M. Rendina
Novel boron‐rich, carboranyl–indole carboxamide ligands were prepared and found to effectively target the 18 kDa translocator protein (TSPO), an upregulated mitochondrial membrane‐bound protein which has been observed in variety of tumor cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8527883eae1babfb698e3cfc9233ab1a
http://hdl.handle.net/11568/1000568
http://hdl.handle.net/11568/1000568
Autor:
Jan Cools, B. De Strooper, Inge Lodewijckx, David Nittner, Lutgarde Serneels, Delphine Verbeke, Tom Taghon, Sofie Demeyer, James Dooley, Ron L. P. Habets, Adrian Liston, C. de Bock, Rajeshwar Narlawar
Publikováno v:
HemaSphere. 3:413-414
Autor:
Shalini Srivastava, Pratik M. Oza, Rajeshwar Narlawar, Ramesh R. Mamidi, Dulal Panda, David E. Hibbs, Anusri Bhattacharya, Emma C. L. Marrs, Kishore Kunal, Paul W. Groundwater, Vivian Wan Yu Liao, John D. Perry, Munikumar Reddy Doddareddy
Publikováno v:
IndraStra Global.
Inhibition of FtsZ assembly has been found to stall bacterial cell division. Here, we report the identification of a potent carbocyclic curcumin analogue (2d) that inhibits Bacillus subtilis 168 cell proliferation by targeting the assembly of FtsZ. 2