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pro vyhledávání: '"Rajeshwar Kumar Yadav"'
Publikováno v:
Current Molecular Medicine. 21:630-644
The nuclear erythroid 2-related-factor (Nrf2) transcription factor/hemoxygenase 1 (HO-1) is a key regulator of an important neuroprotection response by driving the interpretation of various cytoprotective gene to encode for anti-inflammatory, antioxi
Publikováno v:
Current Molecular Pharmacology. 14:263-280
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by the death of upper and lower motor neurons (corticospinal tract) in the motor cortex, basal ganglia, brain stem, and spinal cord. The patient experiences the s
Autor:
Rajeshwar Kumar Yadav, Sidharth Mehan, Rakesh Sahu, Sumit Kumar, Andleeb Khan, Hafiz Antar Makeen, Mohammed Al Bratty
Publikováno v:
Humanexperimental toxicology. 41
Methylmercury (MeHg) is a neurotoxin that induces neurotoxicity and cell death in neurons. MeHg increases oligodendrocyte death, glial cell activation, and motor neuron demyelination in the motor cortex and spinal cord. As a result, MeHg plays an imp
Publikováno v:
CNSneurological disorders drug targets. 20(5)
c-JNK (c-Jun N-terminal kinase) and p38 mitogen-activated protein kinase (MAPK) family members work in a cell-specific manner to regulate neuronal signals. The abnormal activation of these cellular signals can cause glutamate excitotoxicity, disrupte