Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rajeshri G. Karki"'
Autor:
David Kavanagh, Larry A. Greenbaum, Arvind Bagga, Rajeshri G. Karki, Chien-Wei Chen, Sajita Vasudevan, Alan Charney, Marion Dahlke, Fadi Fakhouri
Publikováno v:
Kidney International Reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cc66a59359a566a50952342eb5ee7d0
https://doi.org/10.1016/j.ekir.2023.04.029
https://doi.org/10.1016/j.ekir.2023.04.029
Autor:
Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams
Publikováno v:
Journal of Medicinal Chemistry. 63:5697-5722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161530bd60ced781537b4b5cf97869fc
https://doi.org/10.1021/acs.jmedchem.9b01870
https://doi.org/10.1021/acs.jmedchem.9b01870
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5361-5365
To address the absence of experimental data on the full-length structure of HIV-1 integrase and the way it binds to viral and human DNA, we had previously [Karki, R. G.; Tang, Y.; Burke, T. R., Jr.; Nicklaus, M. C. J. Comput. Aided Mol. Des.2004, 18,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f683b54c99464e8be8d040170d2023
https://doi.org/10.1016/j.bmcl.2007.08.011
https://doi.org/10.1016/j.bmcl.2007.08.011
Autor:
Marc C. Nicklaus, Terrence R. Burke, Lakshman Bindu, Kyeong Lee, Karen M. Worthy, Robert J. Fisher, Sang-Uk Kang, Shinya Oishi, Rajeshri G. Karki, Won Jun Choi
Publikováno v:
Journal of Medicinal Chemistry. 50:1978-1982
A 4-aminopiperidine-4-carboxylic acid residue was placed in the pTyr+1 position of a Grb2 SH2 domain-binding peptide to form a general platform, which was then acylated with a variety of groups to yield a library of compounds designed to explore pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7de272195c86973b0af4fb7703ec06b
https://doi.org/10.1021/jm0614073
https://doi.org/10.1021/jm0614073
Autor:
Robert J. Fisher, Lakshman Bindu, Terrence R. Burke, Shinya Oishi, Karen M. Worthy, Xiangzhu Wang, Sang-Uk Kang, Rajeshri G. Karki, Marc C. Nicklaus
Publikováno v:
Journal of Medicinal Chemistry. 48:764-772
Previous work has shown that incorporation of either 1-aminocyclohexanecarboxylic acid (Ac6c) or alpha-methyl-p-phosphonophenylalanine ((alpha-Me)Ppp) in the phosphotyrosyl (pTyr) C-proximal position (pY + 1 residue) of Grb2 SH2 domain binding peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b6ef1a29f8ba0f6d41c73f62d28ebb
https://doi.org/10.1021/jm0492709
https://doi.org/10.1021/jm0492709
Publikováno v:
Journal of Computer-Aided Molecular Design. 18:739-760
We report structural models of the full-length integrase enzyme (IN) of the human immunodeficiency virus type 1 (HIV-1) and its complex with viral and human DNA. These were developed by means of molecular modeling techniques using all available exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf533b39eb12448190ba9d252e7cc84
https://doi.org/10.1007/s10822-005-0365-5
https://doi.org/10.1007/s10822-005-0365-5
Autor:
Rajeshri G. Karki, Vithal M. Kulkarni
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:3153-3160
Three-dimensional quantitative structure–activity relationship (3D-QSAR) studies for 3-aryloxazolidin-2-one antibacterials were performed using the genetic function approximation algorithm. This study was performed using 60 compounds, in which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef93c5ccce347a6b7bf1730b56d8b2bf
https://doi.org/10.1016/s0968-0896(01)00186-9
https://doi.org/10.1016/s0968-0896(01)00186-9
Autor:
Vithal M. Kulkarni, Rajeshri G. Karki
Publikováno v:
European Journal of Medicinal Chemistry. 36:147-163
A three-dimensional pharmacophore model has been generated for Candida albicans MyristoylCoA: protein N-myristoyltransferase (NMT) inhibitors, using the software program CATALYST. The in vitro NMT inhibitory activity of a series of peptidic inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b982f64b9062601eeb7aad18cf6e86ab
https://doi.org/10.1016/s0223-5234(00)01202-2
https://doi.org/10.1016/s0223-5234(00)01202-2
Autor:
Fa Liu, Marc C. Nicklaus, Rajeshri G. Karki, Melissa Maderia, Terrence R. Burke, Shinya Oishi, Karen M. Worthy, Lakshman Bindu, Robert J. Fisher, Zhen-Dan Shi, Joseph J. Barchi
Publikováno v:
Understanding Biology Using Peptides ISBN: 9780387265698
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4ba3de26d55cfab531f96634042a75f
https://doi.org/10.1007/978-0-387-26575-9_242
https://doi.org/10.1007/978-0-387-26575-9_242
Autor:
Dominic Esposito, Zhen-Dan Shi, Marc C. Nicklaus, Karen M. Worthy, Oleg Chertov, William K. Gillette, Melissa Maderia, Rajeshri G. Karki, Joseph J. Barchi, Terrence R. Burke, James L. Hartley, Lakshman Bindu, Shinya Oishi, Peter Frank, Robert J. Fisher
Publikováno v:
Bioorganicmedicinal chemistry. 13(7)
Preferential binding of ligands to Grb2 SH2 domains in beta-bend conformations has made peptide cyclization a logical means of effecting affinity enhancement. This is based on the concept that constraint of open-chain sequences to bend geometries may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09069aa933adcf92f7bb3bfd549c9e53
https://pubmed.ncbi.nlm.nih.gov/15755645
https://pubmed.ncbi.nlm.nih.gov/15755645