Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Rajesh M Valanparambil"'
Autor:
Rajesh M Valanparambil, Mifong Tam, Pierre-Paul Gros, Jean-Philippe Auger, Mariela Segura, Philippe Gros, Armando Jardim, Timothy G Geary, Keiko Ozato, Mary M Stevenson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006647 (2017)
Interferon regulatory factor-8 (IRF-8) is critical for Th1 cell differentiation and negatively regulates myeloid cell development including myeloid-derived suppressor cells (MDSC). MDSC expand during infection with various pathogens including the gas
Externí odkaz:
https://doaj.org/article/7ed5a4d98cc749188793e07309153a83
Autor:
Rajesh M. Valanparambil, Lilin Lai, Margaret A. Johns, Meredith Davis-Gardner, Susanne L. Linderman, Tarrant Oliver McPherson, Andres Chang, Akil Akhtar, Estefany L. Bocangel Gamarra, Hayley Matia, Ashley A. McCook-Veal, Jeffrey Switchenko, Tahseen H. Nasti, Felicia Green, Manpreet Saini, Andreas Wieland, Benjamin A. Pinsky, Daniel Solis, Madhav V. Dhodapkar, Jennifer Carlisle, Suresh Ramalingam, Rafi Ahmed, Mehul S. Suthar
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-4 (2023)
Abstract This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulating Omicron variants after bivalent booster vaccination and had Ab titers comparable to healthy participants. Interestin
Externí odkaz:
https://doaj.org/article/f3270d0b4e494f458d929fb6e04f135c
Time-Dependent Effects of Clinical Interventions on SARS-CoV-2 Immunity in Patients with Lung Cancer
Autor:
Philip C. Mack, Chih-Yuan Hsu, Ananda M. Rodilla, Jorge E. Gomez, Jazz Cagan, Yuanhui Huang, Sooyun Tavolacci, Rajesh M. Valanparambil, Nicholas Rohs, Rachel Brody, Brittney Nichols, Juan Manuel Carreño, Sheena Bhalla, Christian Rolfo, David E. Gerber, Amy Moore, Jennifer C. King, Rafi Ahmed, John D. Minna, Paul A. Bunn, Adolfo García-Sastre, Florian Krammer, Fred R. Hirsch, Yu Shyr
Publikováno v:
Vaccines, Vol 12, Iss 7, p 713 (2024)
In patients with lung cancer (LC), understanding factors that impact the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) anti-spike antibody (SAb) titers over time is critical, but challenging, due to evolving treatments, inf
Externí odkaz:
https://doaj.org/article/c8cc0c60eaba4193bcab4968d29b9d80
Autor:
Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses ef
Externí odkaz:
https://doaj.org/article/dfaca50a88f74b02a4c1d34e9ba0a73c
Autor:
Andres Chang, Akil Akhtar, Lilin Lai, Victor M. Orellana-Noia, Susanne L. Linderman, Ashley A. McCook-Veal, Jeffrey M. Switchenko, Manpreet Saini, Rajesh M. Valanparambil, Kristie A. Blum, Pamela B. Allen, Mary Jo Lechowicz, Jason T. Romancik, Amy Ayers, Alyssa Leal, Colin B. O'Leary, Michael C. Churnetski, Katelin Baird, Melissa Kives, Jens Wrammert, Ajay K. Nooka, Jean L. Koff, Madhav V. Dhodapkar, Mehul S. Suthar, Jonathon B. Cohen, Rafi Ahmed
Publikováno v:
Cancer Research Communications. 2:1684-1692
Patients with non–Hodgkin lymphoma and chronic lymphocytic leukemia (NHL/CLL) elicit inadequate antibody responses after initial SARS-CoV-2 vaccination and remain at high risk of severe COVID-19 disease. We investigated IgG, IgA, and IgM responses
Autor:
Maryam I. Azeem, Ajay K. Nooka, Uma Shanmugasundaram, Narayanaiah Cheedarla, Sayalee Potdar, Renee Julia Manalo, Alberto Moreno, Jeffrey M. Switchenko, Suneethamma Cheedarla, Deon Bryant Doxie, Roman Radzievski, Madison Leigh Ellis, Kelly E. Manning, Bushra Wali, Rajesh M. Valanparambil, Kathryn T. Maples, Essence Baymon, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, John D. Roback, Alessandro Sette, Rafi Ahmed, Mehul S. Suthar, Andrew S. Neish, Madhav V. Dhodapkar, Kavita M. Dhodapkar
Publikováno v:
Blood Cancer Discovery. 4:106-117
Patients with multiple myeloma (MM) mount suboptimal neutralizing antibodies (nAb) following 2 doses of SARS-CoV-2 mRNA vaccines. Currently, circulating SARS-CoV-2 variants of concern (VOC) carry the risk of breakthrough infections. We evaluated immu
Autor:
Rajesh M. Valanparambil, Jennifer Carlisle, Susanne L. Linderman, Akil Akthar, Ralph Linwood Millett, Lilin Lai, Andres Chang, Ashley A. McCook-Veal, Jeffrey Switchenko, Tahseen H. Nasti, Manpreet Saini, Andreas Wieland, Kelly E. Manning, Madison Ellis, Kathryn M. Moore, Stephanie L. Foster, Katharine Floyd, Meredith E. Davis-Gardner, Venkata-Viswanadh Edara, Mit Patel, Conor Steur, Ajay K. Nooka, Felicia Green, Margaret A. Johns, Fiona O'Brein, Uma Shanmugasundaram, Veronika I. Zarnitsyna, Hasan Ahmed, Lindsay E. Nyhoff, Grace Mantus, Michael Garett, Srilatha Edupuganti, Madhusmita Behra, Rustom Antia, Jens Wrammert, Mehul S. Suthar, Madhav V. Dhodapkar, Suresh Ramalingam, Rafi Ahmed
Publikováno v:
Journal of Clinical Oncology. 40:3808-3816
PURPOSE To examine COVID-19 mRNA vaccine–induced binding and neutralizing antibody responses in patients with non–small-cell lung cancer (NSCLC) to SARS-CoV-2 614D (wild type [WT]) strain and variants of concern after the primary 2-dose and boost
Autor:
Kavita M. Dhodapkar, Madhav V. Dhodapkar, Andrew S. Neish, Mehul S. Suthar, Rafi Ahmed, Alessandro Sette, John D. Roback, Sagar Lonial, Nisha S. Joseph, Craig C. Hofmeister, Jonathan L. Kaufman, Essence Baymon, Kathryn T. Maples, Rajesh M. Valanparambil, Bushra Wali, Kelly E. Manning, Madison Leigh Ellis, Roman Radzievski, Deon Bryant Doxie, Suneethamma Cheedarla, Jeffrey M. Switchenko, Alberto Moreno, Renee Julia Manalo, Sayalee Potdar, Narayanaiah Cheedarla, Uma Shanmugasundaram, Ajay K. Nooka, Maryam I. Azeem
This file contains supplementary figures 1-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a1b2449926acfc08314faeeae3ca5a
https://doi.org/10.1158/2643-3230.22546614
https://doi.org/10.1158/2643-3230.22546614
Autor:
Rafi Ahmed, Jonathon B. Cohen, Mehul S. Suthar, Madhav V. Dhodapkar, Jean L. Koff, Ajay K. Nooka, Jens Wrammert, Melissa Kives, Katelin Baird, Michael C. Churnetski, Colin B. O'Leary, Alyssa Leal, Amy Ayers, Jason T. Romancik, Mary Jo Lechowicz, Pamela B. Allen, Kristie A. Blum, Rajesh M. Valanparambil, Manpreet Saini, Jeffrey M. Switchenko, Ashley A. McCook-Veal, Susanne L. Linderman, Victor M. Orellana-Noia, Lilin Lai, Akil Akhtar, Andres Chang
Supplementary Table 3. Univariate analyses of clinical variables associated with booster response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7dccd14d11fd466124f0fd72f90134
https://doi.org/10.1158/2767-9764.22546017
https://doi.org/10.1158/2767-9764.22546017
Autor:
Kavita M. Dhodapkar, Madhav V. Dhodapkar, Andrew S. Neish, Mehul S. Suthar, Rafi Ahmed, Alessandro Sette, John D. Roback, Sagar Lonial, Nisha S. Joseph, Craig C. Hofmeister, Jonathan L. Kaufman, Essence Baymon, Kathryn T. Maples, Rajesh M. Valanparambil, Bushra Wali, Kelly E. Manning, Madison Leigh Ellis, Roman Radzievski, Deon Bryant Doxie, Suneethamma Cheedarla, Jeffrey M. Switchenko, Alberto Moreno, Renee Julia Manalo, Sayalee Potdar, Narayanaiah Cheedarla, Uma Shanmugasundaram, Ajay K. Nooka, Maryam I. Azeem
Suppl Table 1. Correlative analysis of breakthrough SARS CoV-2 infection following booster vaccination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105016207ddac919082fdc174fe135e7
https://doi.org/10.1158/2643-3230.22546611
https://doi.org/10.1158/2643-3230.22546611