Výsledky vyhledávání - "Rajesh Kishore Kumar Sanku"

Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies

Autor: Rajesh Kishore Kumar Sanku, Qiang Cong, Shrikant Deshpande, Vangipuram S. Rangan, Sanjeev Gangwar, Naidu S. Chowdari, Yam B. Poudel, Chetana Rao, Pina M. Cardarelli, David Passmore, Pavel Strop, Sayumi Yamazoe, Srikanth Kotapati, Gavin Dollinger, Arvind Rajpal

Publikováno v: Analytical Chemistry. 92:2065-2073

Antibody drug conjugates (ADCs) can undergo in vivo biotransformation (e.g., payload metabolism, deconjugation) leading to reduced or complete loss of activity. The location/site of conjugation of payload-linker can have an effect on ADC stability an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a753351fa822ddb82a31837e9e661039
https://doi.org/10.1021/acs.analchem.9b04572

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Potential learning and memory disruptors and enhancers in a simple, 1-day operant task in mice

Autor: Matthew Salkovitz, Marc A. Ilies, Ellen A. Walker, Rajesh Kishore Kumar Sanku, Joel S. John

Publikováno v: Behavioural Pharmacology. 29:482-492

The objective of this study was to develop a rapid, 1-day learning and memory assay in mice that is sensitive to the effects of compounds that could impair or enhance acquisition and retrieval. Swiss-Webster, male mice were placed in experimental cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ed9c1b11a3110d87682971c40dd0dc
https://doi.org/10.1097/fbp.0000000000000400

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Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors

Autor: Suleyman Akocak, Nabih Lolak, Rajesh Kishore Kumar Sanku, Claudiu T. Supuran, Silvia Bua

Publikováno v: Bioorganicmedicinal chemistry. 27(8)

A series of twenty novel ureido benzenesulfonamides incorporating 1,3,5-triazine moieties substituted on one side with aromatic amines and on the other side with dimethylamine, morpholine and piperidine is reported. The compounds were synthesized fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5302ab3a07fa0893c6fd0b8f50f281
https://pubmed.ncbi.nlm.nih.gov/30846402

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PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas

Autor: Marc A. Ilies, Daniela Vullo, Harry Thompson, Erik R. Swenson, Claudiu T. Supuran, M. Raqibul Alam, Suleyman Akocak, Ahmed M. Shabana, Rajesh Kishore Kumar Sanku

Publikováno v: Journal of Medicinal Chemistry. 59:5077-5088

A series of aromatic/heterocyclic bis-sulfonamides were synthesized from three established aminosulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor pharmacophores, coupled with either ethylene glycol oligomeric or polymeric diamines to yield bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d615027111eb286bdbf5705f0a1e22b
https://doi.org/10.1021/acs.jmedchem.6b00492

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Pyridinium derivatives of 3-aminobenzenesulfonamide are nanomolar-potent inhibitors of tumor-expressed carbonic anhydrase isozymes CA IX and CA XII

Autor: Suleyman Akocak, Rajesh Kishore Kumar Sanku, Claudiu T. Supuran, Özlen Güzel-Akdemir, Samson S. Russom, Bogdan I. Iorga, Marc A. Ilies

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2020, 103, pp.104204. ⟨10.1016/j.bioorg.2020.104204⟩
Bioorg Chem

International audience; Building on the conclusions of previous inhibition studies with pyridinium-benzenesulfonamides from our team and on the X-ray crystal structure of the lead compound identified, a series of 24 pyridinium derivatives of 3-aminob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea67f6bb713c81a538538022b260d9b
https://doi.org/10.1016/j.bioorg.2020.104204

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Design, synthesis and biological evaluation of 1,3-diaryltriazenesubstituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors

Autor: Nabih Lolak, Mehmet Boga, Rajesh Kishore Kumar Sanku, Suleyman Akocak, Muhammed Tuneg

Publikováno v: Volume: 6, Issue: 1 63-70
Journal of the Turkish Chemical Society Section A: Chemistry
Journal of the Turkish Chemical Society, Section A: Chemistry, Vol 6, Iss 1, Pp 63-70 (2019)

1,3-diaryltriazenes are one of the most useful and important linkers for many pharmaceutical applications. Therefore, in the current work, a series of 1,3-diaryltriazene sulfonamides 4(a-k) were synthesized by reacting diazonium salt of sulfanilamide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833e7650b85dd6bf479a213da4fc571f
https://dergipark.org.tr/tr/pub/jotcsa/issue/42264/516444