Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rajesh Karuturi"'
Publikováno v:
Molecules, Vol 20, Iss 1, Pp 608-624 (2015)
Plasmin, a key serine protease, plays a major role in clot lysis and extracellular matrix remodeling. Heparin, a natural polydisperse sulfated glycosaminoglycan, is known to allosterically modulate plasmin activity. No small allosteric inhibitor of p
Externí odkaz:
https://doaj.org/article/6f3de1d2b5bd45059d35dcbfd2c2b3ed
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0160189 (2016)
Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors. Yet, allosteric inhibition of FXIIIa is a paradigm that may offe
Externí odkaz:
https://doaj.org/article/1fb45436284b443e823ef4bf5c1506f3
Publikováno v:
In Tetrahedron: Asymmetry 2008 19(12):1509-1513
Autor:
Rami A. Al-Horani, Nehru Viji Sankaranarayanan, Rajesh Karuturi, Daniel K. Afosah, Rio S. Boothello, Umesh R. Desai
Publikováno v:
Bioorg Med Chem
Human factor XIa (hFXIa) has emerged as an attractive target for development of new anticoagulants that promise higher level of safety. Different strategies have been adopted so far for the design of anti-hFXIa molecules including competitive and non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d924da8162938dbe6284710cd5134c7b
https://pubmed.ncbi.nlm.nih.gov/32992249
https://pubmed.ncbi.nlm.nih.gov/32992249
Autor:
Rami A. Al-Horani, Rio S. Boothello, Stephen Verespy, Rajesh Karuturi, Umesh R. Desai, Daniel K. Afosah
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1101-1105
Despite the development of promising direct oral anticoagulants, which are all orthosteric inhibitors, a sizable number of patients suffer from bleeding complications. We have hypothesized that allosterism based on the heparin-binding exosites presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f40f888fe19676449767b0be0a6826e
https://doi.org/10.1016/j.bmcl.2018.01.069
https://doi.org/10.1016/j.bmcl.2018.01.069
Publikováno v:
Journal of Medicinal Chemistry. 56:2415-2428
To discover promising sulfated allosteric modulators (SAMs) of glycosaminoglycan-binding proteins (GBPs), such as human factor XIa (FXIa), we screened a library of 26 synthetic, sulfated quinazolin-4(3H)-ones (QAOs) resulting in the identification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5540c534edfeb58516f54bb5227b3cf
https://doi.org/10.1021/jm301757v
https://doi.org/10.1021/jm301757v
Publikováno v:
ChemInform. 47
In nearly all cases of biological activity of sulfated GAGs, the sulfate group(s) are critical for interacting with target proteins. A growing paradigm is that appropriate small, sulfated, nonsaccharide GAG mimetics can be designed to either mimic or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fefcc2a4633b83734cff2f9d0a5ccae
https://doi.org/10.1002/chin.201634216
https://doi.org/10.1002/chin.201634216
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4467-4470
Tumor-associated angiogenesis is a complex process that involves the interplay among several molecular players such as cell-surface heparan sulfate proteoglycans, vascular endothelial growth factors and their cognate receptors. PI-88, a highly sulfon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652c3cb7f31cdee17318f72d28085bb9
https://doi.org/10.1016/j.bmcl.2012.04.014
https://doi.org/10.1016/j.bmcl.2012.04.014
Autor:
Elsamani I. Abdelfadiel, Shravan Morla, Bhaumik B. Patel, Umesh R. Desai, Rajesh Karuturi, Chetna Sharon, Nirmita J. Patel, Rio S. Boothello, Donald F. Brophy, Robert H. Lippman
Publikováno v:
Gastroenterology. 154:S-114
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dac5ae618ae05761846ba8dca1d09ede
https://doi.org/10.1016/s0016-5085(18)30817-5
https://doi.org/10.1016/s0016-5085(18)30817-5
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1229
In nearly all cases of biological activity of sulfated GAGs, the sulfate group(s) are critical for interacting with target proteins. A growing paradigm is that appropriate small, sulfated, nonsaccharide GAG mimetics can be designed to either mimic or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ee07662cdd0172da736bf2390ccb3e5
https://pubmed.ncbi.nlm.nih.gov/25325944
https://pubmed.ncbi.nlm.nih.gov/25325944