Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans

Autor: Rufus O. Akinyemi, Hemant K. Tiwari, Vinodh Srinivasasainagendra, Onoja Akpa, Fred S. Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O. Osaigbovo, Olga A. Mamaeva, Brian A. Halloran, Joshua Akinyemi, Daniel Lackland, Olugbo Y. Obiabo, Taofik Sunmonu, Innocent I. Chukwuonye, Oyedunni Arulogun, Carolyn Jenkins, Abiodun Adeoye, Atinuke Agunloye, Okechukwu S. Ogah, Godwin Ogbole, Adekunle Fakunle, Ezinne Uvere, Motunrayo M. Coker, Akinkunmi Okekunle, Osahon Asowata, Samuel Diala, Mayowa Ogunronbi, Osi Adeleye, Ruth Laryea, Raelle Tagge, Sunday Adeniyi, Nathaniel Adusei, Wisdom Oguike, Paul Olowoyo, Olayinka Adebajo, Abimbola Olalere, Olayinka Oladele, Joseph Yaria, Bimbo Fawale, Philip Ibinaye, Olalekan Oyinloye, Yaw Mensah, Omotola Oladimeji, Josephine Akpalu, Benedict Calys-Tagoe, Hamisu A. Dambatta, Adesola Ogunniyi, Rajesh Kalaria, Donna Arnett, Charles Rotimi, Bruce Ovbiagele, Mayowa O. Owolabi, for the SIREN Team

Publikováno v: Genome Medicine, Vol 16, Iss 1, Pp 1-22 (2024)

Abstract Background African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study in

Externí odkaz: https://doaj.org/article/a680451a51ed4370a4e15c10017dc03f

TRAJECTORIES OF COGNITIVE CHANGE FOLLOWING STROKE: A STEPWISE DECLINE TOWARDS DEMENTIA

Autor: Joao Delgado, Louise Allan, Rajesh Kalaria

Publikováno v: Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100056- (2024)

Externí odkaz: https://doaj.org/article/65eb06d300d04f78a34494fc9bbd61a4

The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis

Autor: Bonnie Yin Ka Lam, Yuan Cai, Rufus Akinyemi, Geert Jan Biessels, Hilde van den Brink, Christopher Chen, Chin Wai Cheung, King Ngai Chow, Henry Kwun Hang Chung, Marco Duering, Siu Ting Fu, Deborah Gustafson, Saima Hilal, Vincent Ming Ho Hui, Rajesh Kalaria, SangYun Kim, Maggie Li Man Lam, Frank Erik de Leeuw, Ami Sin Man Li, Hugh Stephen Markus, Anna Marseglia, Huijing Zheng, John O’Brien, Leonardo Pantoni, Perminder Singh Sachdev, Eric E Smith, Joanna Wardlaw, Vincent Chung Tong Mok

Publikováno v: International Journal of Stroke, 18, 15-27
Lam, B Y K, Cai, Y, Akinyemi, R, Biessels, G J, van den Brink, H, Chen, C, Cheung, C W, Chow, K N, Chung, H K H, Duering, M, Fu, S T, Gustafson, D, Hilal, S, Hui, V M H, Kalaria, R, Kim, S, Lam, M L M, de Leeuw, F E, Li, A S M, Markus, H S, Marseglia, A, Zheng, H, O'Brien, J, Pantoni, L, Sachdev, P S, Smith, E E, Wardlaw, J & Mok, V C T 2022, ' The global burden of cerebral small vessel disease in low-and middle-income countries : A systematic review and meta-analysis ', International Journal of Stroke, pp. 17474930221137019 . https://doi.org/10.1177/17474930221137019
International Journal of Stroke, 18, 1, pp. 15-27

Background: Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. Previous studies on the prevalence of cSVD are mostly based on single geographically defined cohorts in high-income countries. Studies investigating the prevale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c8e972de70e39a5010f743ece49735
https://doi.org/10.1177/17474930221137019

Symbolic legislation and the regulation of stroke biobanking and genomics research in Sub-Saharan Africa

Autor: Muyiwa Adigun, Babatunde Raphael Ojebuyi, Joshua Akinyemi, Kolawole Wahab, Albert Akpalu, Fred S. Sarfo, Lukman F. Owolabi, Rabiu Musbahu, Abiodun Bello, Reginald Obiako, Mayowa Ogunronbi, Arti Singh, Michelle Nichols, Carolyn Jenkins, Ayodele Jegede, Rajesh Kalaria, Mayowa Owolabi, Bruce Ovbiagele, Oyedunni Arulogun, Rufus Akinyemi

Publikováno v: Theory Pract Legis

Stroke is a major cause of death in Sub-Saharan Africa (SSA) and genetic factors appear to play a part. This led to the development of stroke bio-banking and genomics research in SSA. Existing stroke studies have focused on causes, incidence rates, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f033fc470c1aefcb81a352b8e993aede
https://doi.org/10.1080/20508840.2022.2025741

Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease

Autor: Jessica Lisa Littau, Lina Velilla, Yoshiki Hase, Nelson David Villalba‐Moreno, Christian Hagel, Dagmar Drexler, Santiago Osorio Restrepo, Andres Villegas, Francisco Lopera, Sergio Vargas, Markus Glatzel, Susanne Krasemann, Yakeel T. Quiroz, Joseph F. Arboleda‐Velasquez, Rajesh Kalaria, Diego Sepulveda‐Falla

Publikováno v: Brain Pathology. 32

We studied small vessel disease (SVD) pathology in Familial Alzheimer's disease (FAD) subjects carrying the presenilin 1 (PSEN1) p.Glu280Ala mutation in comparison to those with sporadic Alzheimer's disease (SAD) as a positive control for Alzheimer's

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378efef7a36cb647b980fdac650726b2
https://doi.org/10.1111/bpa.13097