Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Rajesh B. Shankar"'
Autor:
Albi Francis, Javed S. Shaikh, Tariq Bhat, Sanjay P. Kurhade, Nivrutti Kamble, Harish Volam, Sadanand Mallurwar, Pushpak Bora, Prashant B. Nigade, Mandar Bhonde, Hemant Goyal, Gagan Kukreja, Nishant R. Gupta, Nageswara Rao Irlapati, Prajakta Ahirrao, Bernstein Peter Robert, Rajesh B. Shankar, Kumar Ram Naik, Sneha Naidu, Gopal Gole, Yogesh Pawar, Apparao Bommakanti, Vinod Patil, Rajendra G. Powar, V.R. Praveen Kumar, Rakesh Kumar, Prabhakaran Kamalakannan, Anil K. Hajare, Neelima Sinha, Rajender Kumar Kamboj, Jayasagar Gundu, Sharad Sharma, Nilesh Khedkar, Arun R. Jagdale, Navnath P. Karche, Venkata P. Palle, Dipak Modi, Saif Wahid, Vamsi Pagdala, Kochumalayil Shaji George, Ganesh R. Jadhav, Gourhari Jana, Rohan Limaye, Baban Thube, Lakshmi Narasimham, Harshal Khanwalkar, Shashikant Pawar, Kumar V.S. Nemmani, Rajesh Gupta, Minakshi Singh, Ramesh Kale, Ajay R. Tilekar, Samiron Phukan, Dhananjay Bakhle, Pradipta Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115819
The exploitation of GLU988 and LYS903 residues in PARP1 as targets to design isoquinolinone (I & II) and naphthyridinone (III) analogues is described. Compounds of structure I have good biochemical and cellular potency but suffered from inferior PK.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae439561d9cd7678612504a2221cbc22
https://doi.org/10.1016/j.bmc.2020.115819
https://doi.org/10.1016/j.bmc.2020.115819
