Výsledky vyhledávání - "Rajesh Ambasudhan"

Akademický článek

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

Autor: Tammy Ryan, Vladimir V. Bamm, Morgan G. Stykel, Carla L. Coackley, Kayla M. Humphries, Rhiannon Jamieson-Williams, Rajesh Ambasudhan, Dick D. Mosser, Stuart A. Lipton, George Harauz, Scott D. Ryan

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.

Externí odkaz: https://doaj.org/article/0839cad1dc084b31b2fb1c7ae7cd4162

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Akademický článek

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can

Externí odkaz: https://doaj.org/article/386d48d4311a447bb8bff05a85d294e7

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Akademický článek

Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

Autor: Aman P. Mann, Pablo Scodeller, Sazid Hussain, Gary B. Braun, Tarmo Mölder, Kadri Toome, Rajesh Ambasudhan, Tambet Teesalu, Stuart A. Lipton, Erkki Ruoslahti

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Cerebrovascular changes and astrogliosis occur in Alzheimer’s disease (AD). Using an in vivo phage display technique, the authors identified a peptide that upon systematic administration, can home to brain endothelial cells and astrocytes in mouse

Externí odkaz: https://doaj.org/article/be95d3c6783044f889e270600ff9b0e4

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Akademický článek

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

Autor: Chang-Ki Oh, Abdullah Sultan, Joseph Platzer, Nima Dolatabadi, Frank Soldner, Daniel B. McClatchy, Jolene K. Diedrich, John R. Yates, III, Rajesh Ambasudhan, Tomohiro Nakamura, Rudolf Jaenisch, Stuart A. Lipton

Publikováno v: Cell Reports, Vol 21, Iss 8, Pp 2171-2182 (2017)

Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson’s disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. Here, we report that environ

Externí odkaz: https://doaj.org/article/6cbba4e38c0245ebabf9b742b039a55d

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Akademický článek

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

Autor: Swagata Ghatak, Nima Dolatabadi, Dorit Trudler, XiaoTong Zhang, Yin Wu, Madhav Mohata, Rajesh Ambasudhan, Maria Talantova, Stuart A Lipton

Publikováno v: eLife, Vol 8 (2019)

Human Alzheimer’s disease (AD) brains and transgenic AD mouse models manifest hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that represents the major pathophysiological correlate of cognitive decline. Howeve

Externí odkaz: https://doaj.org/article/31d6c80f1cdd4aa0ba5795f6be3ccee7

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Akademický článek

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

Autor: Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi, James Parker, Kevin Chon, Michelle S. Lee, Walid Soussou, Scott R. McKercher, Rajesh Ambasudhan, Tomohiro Nakamura, Stuart A. Lipton

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberra

Externí odkaz: https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f235

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Akademický článek

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

Autor: Tomohiro Nakamura, Olga A. Prikhodko, Elaine Pirie, Saumya Nagar, Mohd Waseem Akhtar, Chang-Ki Oh, Scott R. McKercher, Rajesh Ambasudhan, Shu-ichi Okamoto, Stuart A. Lipton

Publikováno v: Neurobiology of Disease, Vol 84, Iss , Pp 99-108 (2015)

Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups. For instance, S-nitrosylation regulates enzymatic

Externí odkaz: https://doaj.org/article/f1f59b9dd3d54f7b9aa8622cf6a1bca9

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Akademický článek

Publisher Correction: Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

Autor: Aman P. Mann, Pablo Scodeller, Sazid Hussain, Gary B. Braun, Tarmo Mölder, Kadri Toome, Rajesh Ambasudhan, Tambet Teesalu, Stuart A. Lipton, Erkki Ruoslahti

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

The original version of the Supplementary Information associated with this Article inadvertently omitted Supplementary Table 1. The HTML has now been updated to include a corrected version of the Supplementary Information.

Externí odkaz: https://doaj.org/article/05711ee206ad483dbc19cd01c9978f8d

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