Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Rajesh A Jacob"'
Autor:
Venkatesh P Kashi, Rajesh A Jacob, Raghavendra A Shamanna, Malini Menon, Anangi Balasiddaiah, Rebu K Varghese, Mahesh Bachu, Udaykumar Ranga
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114155 (2014)
Extracellular Tat (eTat) plays an important role in HIV-1 pathogenesis. The presence of anti-Tat antibodies is negatively correlated with disease progression, hence making Tat a potential vaccine candidate. The cytotoxicity and moderate immunogenicit
Externí odkaz:
https://doaj.org/article/d4c9310efe134dfaae2c08f3503692ba
Autor:
Rajesh Abraham Jacob, Ali Zhang, Hannah O. Ajoge, Michael R. D'Agostino, Kuganya Nirmalarajah, Altynay Shigayeva, Wael L. Demian, Sheridan J.C. Baker, Hooman Derakhshani, Laura Rossi, Jalees A. Nasir, Emily M. Panousis, Ahmed N. Draia, Christie Vermeiren, Jodi Gilchrist, Nicole Smieja, David Bulir, Marek Smieja, Michael G. Surette, Andrew G. McArthur, Allison J. McGeer, Samira Mubareka, Arinjay Banerjee, Matthew S. Miller, Karen Mossman
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 7, Pp 1386-1396 (2023)
Isolating and characterizing emerging SARS-CoV-2 variants is key to understanding virus pathogenesis. In this study, we isolated samples of the SARS-CoV-2 R.1 lineage, categorized as a variant under monitoring by the World Health Organization, and ev
Externí odkaz:
https://doaj.org/article/58f15a2383ca46c58c985660a3da820d
Autor:
Idrissa Diallo, Rajesh Abraham Jacob, Elodie Vion, Robert A. Kozak, Karen Mossman, Patrick Provost
Publikováno v:
Viruses, Vol 15, Iss 2, p 496 (2023)
Numerous proteomic and transcriptomic studies have been carried out to better understand the current multi-variant SARS-CoV-2 virus mechanisms of action and effects. However, they are mostly centered on mRNAs and proteins. The effect of the virus on
Externí odkaz:
https://doaj.org/article/22065a887f994333a5e3cbbd43720f72
Autor:
Arinjay Banerjee, Nader El-Sayes, Patrick Budylowski, Rajesh Abraham Jacob, Daniel Richard, Hassaan Maan, Jennifer A. Aguiar, Wael L. Demian, Kaushal Baid, Michael R. D'Agostino, Jann Catherine Ang, Tetyana Murdza, Benjamin J.-M. Tremblay, Sam Afkhami, Mehran Karimzadeh, Aaron T. Irving, Lily Yip, Mario Ostrowski, Jeremy A. Hirota, Robert Kozak, Terence D. Capellini, Matthew S. Miller, Bo Wang, Samira Mubareka, Allison J. McGeer, Andrew G. McArthur, Andrew C. Doxey, Karen Mossman
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102477- (2021)
Summary: Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production i
Externí odkaz:
https://doaj.org/article/7903286efe6640018b5c5ad804e712c6
Autor:
Charles Yin, Angela M. Vrieze, Mara Rosoga, James Akingbasote, Emily N. Pawlak, Rajesh Abraham Jacob, Jonathan Hu, Neha Sharma, Jimmy D. Dikeakos, Lillian Barra, A. Dave Nagpal, Bryan Heit
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The loss of efferocytosis—the phagocytic clearance of apoptotic cells—is an initiating event in atherosclerotic plaque formation. While the loss of macrophage efferocytosis is a prerequisite for advanced plaque formation, the transcriptional and
Externí odkaz:
https://doaj.org/article/6e5624ae10244ba3b4cb3c0f457845ec
Autor:
Idrissa Diallo, Rajesh Abraham Jacob, Elodie Vion, Robert A. Kozak, Karen Mossman, Patrick Provost
Publikováno v:
Viruses
Volume 15
Issue 2
Pages: 496
Volume 15
Issue 2
Pages: 496
Numerous proteomic and transcriptomic studies have been carried out to better understand the current multi-variant SARS-CoV-2 virus mechanisms of action and effects. However, they are mostly centered on mRNAs and proteins. The effect of the virus on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc92d083ec7dfeaf2fc23832f8738c7b
Autor:
Shawna L. Semple, Sarah K. W. Au, Rajesh A. Jacob, Karen L. Mossman, Stephanie J. DeWitte-Orr
Publikováno v:
Frontiers in immunology. 13
In invertebrate cells, RNA interference (RNAi) acts as a powerful immune defense that stimulates viral gene knockdown thereby preventing infection. With this pathway, virally produced long dsRNA (dsRNA) is cleaved into short interfering RNA (siRNA) b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869f03046f05f29a38d1eb565058f00f
https://pubmed.ncbi.nlm.nih.gov/35603190
https://pubmed.ncbi.nlm.nih.gov/35603190
Autor:
Brennan S Dirk, Rajesh Abraham Jacob, Aaron L Johnson, Emily N Pawlak, P Craig Cavanagh, Logan Van Nynatten, S M Mansour Haeryfar, Jimmy D Dikeakos
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125619 (2015)
The Human Immunodeficiency Virus type 1 (HIV-1) accessory protein Nef interacts with a multitude of cellular proteins, manipulating the host membrane trafficking machinery to evade immune surveillance. Nef interactions have been analyzed using variou
Externí odkaz:
https://doaj.org/article/4e674cd7cf0943a489f443bf3392ca5c
Autor:
Jimmy D. Dikeakos, Cassandra R Edgar, Andrés Finzi, S. M. Mansour Haeryfar, Alexa Galbraith, Jérémie Prévost, Mitchell J. Mumby, Rajesh Abraham Jacob, Frank Kirchhoff, Antony Lurie, Steven M. Trothen
Publikováno v:
The Journal of Biological Chemistry
Prolonged immune activation drives the upregulation of multiple checkpoint receptors on the surface of virus-specific T cells, inducing their exhaustion. Reversing HIV-1-induced T cell exhaustion is imperative for efficient virus clearance; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4498fbba12fc0bc9e4265261297f405
http://europepmc.org/articles/PMC8390549
http://europepmc.org/articles/PMC8390549
Autor:
Daniel Richard, Aaron T. Irving, Wael L. Demian, Sam Afkhami, Jennifer A. Aguiar, Allison McGeer, Nader El-Sayes, Rajesh Abraham Jacob, Andrew C. Doxey, Lily Yip, Mehran Karimzadeh, Arinjay Banerjee, Karen L. Mossman, Mario A. Ostrowski, Bo Wang, Kaushal Baid, Jeremy A. Hirota, Robert A. Kozak, Andrew G. McArthur, Matthew S. Miller, Hassaan Maan, Michael R. D’Agostino, Patrick Budylowski, Jann Catherine Ang, Terence D. Capellini, Samira Mubareka, Tetyana Murdza, Benjamin J.-M. Tremblay
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102477-(2021)
iScience
iScience
Type I interferons (IFNs) are our first line of defence against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production is associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f629b56fdbb9273dc84d159762d5b2
https://pubmed.ncbi.nlm.nih.gov/33937724
https://pubmed.ncbi.nlm.nih.gov/33937724