Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rajesh R. Iyengar"'
Autor:
Susana S. Correia, Guang Liu, Sarah Jacobson, Sylvie G. Bernier, Jenny V. Tobin, Chad D. Schwartzkopf, Emily Atwater, Elisabeth Lonie, Sam Rivers, Andrew Carvalho, Peter Germano, Kim Tang, Rajesh R. Iyengar, Mark G. Currie, John R. Hadcock, Christopher J. Winrow, Juli E. Jones
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating n
Externí odkaz:
https://doaj.org/article/b9dc10997df94c7186de03737efe4dd1
Autor:
Susana S. Correia, Rajesh R. Iyengar, Peter Germano, Kim Tang, Sylvie G. Bernier, Chad D. Schwartzkopf, Jenny Tobin, Thomas W.-H. Lee, Guang Liu, Sarah Jacobson, Andrew Carvalho, Glen R. Rennie, Joon Jung, Paul A. Renhowe, Elisabeth Lonie, Christopher J. Winrow, John R. Hadcock, Juli E. Jones, Mark G. Currie
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that binds to soluble guanylate cyclas
Externí odkaz:
https://doaj.org/article/77b2ed6c8b9c4de4b87274d76d632880
Autor:
Sylvie G. Bernier, Peter Germano, Christopher J. Winrow, Chad D. Schwartzkopf, Susana S. Correia, Kim Tang, Juli E. Jones, Sam Rivers, Elisabeth Lonie, Guang Liu, Sarah Jacobson, Andrew Carvalho, Jenny Tobin, John R. Hadcock, Emily Atwater, Rajesh R. Iyengar, Mark G. Currie
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating neuroinfla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199a830a1937f260ccf762e3f641c144
https://doi.org/10.1186/s12974-021-02275-z
https://doi.org/10.1186/s12974-021-02275-z
Autor:
Andrew Carvalho, Kim Tang, Christopher J. Winrow, John R. Hadcock, Sarah Jacobson, Jenny Tobin, Elisabeth Lonie, Sylvie G. Bernier, Thomas W.-H. Lee, Susana S. Correia, Rennie Glen Robert, Chad D. Schwartzkopf, Joon Jung, Peter Germano, Guang Liu, Juli E. Jones, Mark G. Currie, Paul Allan Renhowe, Rajesh R. Iyengar
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that binds to soluble guanylate cyclas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32016c7ebcec298b36c97328d53b8a4
https://www.frontiersin.org/articles/10.3389/fphar.2021.656561/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.656561/full
Autor:
Jia Lei, Joon Jung, Sylvie G. Bernier, Joel D. Moore, Glen Rennie, Mermerian Ara, Nicholas Robert Perl, Thomas Wai-Ho Lee, Andrew Carvalho, Barden Timothy Claude, Peter Germano, Jenny Tobin, Colleen Hudson, Renee Deming, Rajesh R. Iyengar, Takashi Nakai, G-Yoon Jamie Im, Paul A. Renhowe, Daniel P. Zimmer, Elise Kim
Publikováno v:
Bioorganicmedicinal chemistry letters. 40
Soluble guanylate cyclase (sGC) is a clinically validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC have the potential to treat diseases that are affected by dysregulation of the NO-sGC-cGMP signal transduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9de2bad2e2d41649c98451bf1e9a94
https://pubmed.ncbi.nlm.nih.gov/33662540
https://pubmed.ncbi.nlm.nih.gov/33662540
Autor:
Gilbert Diaz, Lee C. Preusser, Ann Mikhail, Christopher A. Ogiela, Lynch John K, Philip R. Kym, Lisa M. Hernández, Dariusz Wodka, Gang Zhao, Doug H. Falls, Eugene N. Bush, James S. Polakowski, Andrew S. Judd, Robin Shapiro, Hing L. Sham, James J. Napier, Christine A. Collins, Kennan C. Marsh, Victoria Knourek-Segel, Glenn A. Reinhart, Thomas J Campbell, Sevan Brodjian, Michael E. Brune, Brian A. Droz, Mathew M. Mulhern, Kathryn Houseman, Regina M. Reilly, Brian D. Dayton, Ryan M. Fryer, James T. Limberis, Rajesh R. Iyengar, Freeman Jennifer C
Publikováno v:
Journal of Medicinal Chemistry. 49:6569-6584
Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a chromone-2-carboxamide series as having excellent safety against t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b667ab564d57ac2f27112dd9382a72ab
https://doi.org/10.1021/jm060683e
https://doi.org/10.1021/jm060683e
Autor:
Chen Zhao, Anil Vasudevan, Timothy A. Esbenshade, Philip R. Kym, Arthur A. Hancock, Gerard B. Fox, Kelly B. Gallagher, Ana M. Basso, Andrew J. Souers, Rajesh R. Iyengar, Martin Schmidt, Christine A. Collins, Lynne E. Rueter, Natalie A. Bratcher, Minghua Sun, Marlon D. Cowart, Michael E. Brune
Publikováno v:
European Journal of Pharmacology. 540:115-120
The aim of this study was to validate melanin-concentrating hormone (MCH)-1 receptor antagonism as a potential treatment of mood disorders. We attempted to replicate the effects previously reported with SNAP-7941 and expanded the investigation to thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bb45b864969b82c256622c8e75d6d3
https://doi.org/10.1016/j.ejphar.2006.04.043
https://doi.org/10.1016/j.ejphar.2006.04.043
Autor:
Hing L. Sham, Regina M. Reilly, Freeman Jennifer C, Lee C. Preusser, Mathew M. Mulhern, Dariusz Wodka, Kennan C. Marsh, Andrew S. Judd, Jason A. Segreti, Ryan M. Fryer, Rajesh R. Iyengar, Gang Zhao, Lynch John K, Brian D. Dayton, Sevan Brodjian, Anil Vasudevan, Lisa M. Hernández, James J. Napier, Christine A. Collins, Seble Wagaw, Glenn A. Reinhart, Thomas J Campbell, Andrew J. Souers, Ju Gao, James S. Polakowski, Philip R. Kym
Publikováno v:
Journal of Medicinal Chemistry. 49:2339-2352
An inactin-anesthetized rat cardiovascular (CV) assay was employed in a screening mode to triage multiple classes of melanin-concentrating hormone receptor 1 (MCHr1) antagonists. Lead identification was based on a compound profile producing high drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619be8483639af871b30640981ceee6d
https://doi.org/10.1021/jm0512286
https://doi.org/10.1021/jm0512286
Autor:
Christine A. Collins, Victoria Knourek-Segel, Philip R. Kym, Dariusz Wodka, Hing L. Sham, Brad J. Geddes, Rajesh R. Iyengar, Anil Vasudevan, Ju Gao, Su Jen Lai, Elizabeth K. Govek, Thomas A. Fey, Freeman Jennifer C, Gang Zhao, Dennis G Fry, Michael E. Brune, Jennifer Lee Che, Brian D. Dayton, Doug H. Falls, Kennan C. Marsh, Andrew J. Souers, James Brown, Jon Roses, Michael A. Patane, Matthew J. LaMarche, Cathleen Mcdowell, Lee C. Preusser, Lisa E. Hernandez, Mathew M. Mulhern, Courtney Cullis, Tom Marsilje, Sevan Brodjian, Lynch John K, Eugene N. Bush, Sells Todd B, Robin Shapiro, Christopher Blackburn, Andrew S. Judd, Glenn A. Reinhart
Publikováno v:
Journal of Medicinal Chemistry. 48:5888-5891
4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2-one (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagonist that causes dose-dependent weight loss in diet-induced obese mice. Further e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b385adec4f57fc115bc33dad4a4acdf7
https://doi.org/10.1021/jm050598r
https://doi.org/10.1021/jm050598r
Autor:
Mathew M. Mulhern, Yau Yi Lau, Hing L. Sham, Zhi Su, Gang Zhao, Brian A. Droz, Xiaojun Wang, Kennan C. Marsh, Seble Wagaw, Christine A. Collins, Jennifer L. Freeman, Michael E. Brune, Nelson Grihalde, Rajesh R. Iyengar, Kenneth M. Engstrom, Gilbert Diaz, Regina M. Reilly, Lynch John K, Matthew M. Ravn, David W A Beno, Philip R. Kym, Ju Gao, Sevan Brodjian, H. Doug Falls, Brian D. Dayton, Martin J. Voorbach, Dennis G Fry, Andrew J. Souers, Andrew S. Judd
Publikováno v:
Journal of medicinal chemistry. 51(3)
A highly potent and selective DGAT-1 inhibitor was identified and used in rodent models of obesity and postprandial chylomicron excursion to validate DGAT-1 inhibition as a novel approach for the treatment of metabolic diseases. Specifically, compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61d8d74e1723130c95fb0f63edbf2df
https://pubmed.ncbi.nlm.nih.gov/18183944
https://pubmed.ncbi.nlm.nih.gov/18183944