Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Rajendra S. Bhatnagar"'
Autor:
Rajendra S. Bhatnagar, Rao S. Rapaka
Publikováno v:
International Journal of Peptide and Protein Research. 7:475-480
The sequential copolymer (Pro-Pro-β-Ala)n has been synthesized as a model for collagen. Preliminary studies indicate that the polymer may bear conformational resemblance to collagen.
Autor:
Rao S. Rapaka, Rajendra S. Bhatnagar
Publikováno v:
International Journal of Peptide and Protein Research. 8:371-377
The synthesis of two collagen models (Pro-Pro-Ala)n and (Pro-Pro-Val)n is reported. Preliminary examination suggests that (Pro-Pro-Ala)n may exhibit some properties of collagen-like polypeptides whereas (Pro-Pro-Val)n, does not have a collagen-like c
Publikováno v:
Tissue Engineering. 10:1148-1159
Type I collagen provides a structural framework for connective tissues and plays a central role in the temporal cascade of events leading to the formation of new bone from progenitors. The aim of this study was to examine the ability of the cell-bind
Publikováno v:
Biochemical and Biophysical Research Communications. 311:179-186
The cells in bone grow on a composite matrix made up of mineral and organic (mainly type-I collagen) components. In this study, anorganic bone mineral (ABM) particles were coated with a cell-binding domain of type-I collagen (P-15 peptide) to mimic t
Publikováno v:
Connective Tissue Research. 42:59-69
Cartilage formation during embryonic development and in fracture healing in adult animals involves chondrogenic differentiation of mesenchymal precursors. Here we describe an in vitro model whereby human dermal fibroblasts, considered to be restricte
Autor:
Rajendra S. Bhatnagar, Mustafa Emre Bakircioglu, Ahmed I. El-Sakka, Tom F. Lue, Tien-Sze Benedict Yen, Rajvir Dahiya
Publikováno v:
Journal of Urology. 161:1980-1983
Purpose: We have developed an animal model of Peyronie's disease by injecting transforming growth factor beta (TGF-beta) into the rat penis. Our objective is to study the effects of colchicine on the Peyronie's condition in an animal model.Materials
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 14:547-560
In its physiological solid state, type I collagen serves as a host for many types of cells. Only the molecules on fiber surface are available for interaction. In this interfacial environment, the conformation of a cell binding domain can be expected
Autor:
Rajendra S. Bhatnagar, Jing Jing Qian
Publikováno v:
Journal of Biomedical Materials Research. 31:545-554
We have examined the ability of a synthetic 15-residue peptide, P-15, related to a biologically active domain of type I collagen, to promote attachment of human dermal fibroblasts to anorganic bovine bone mineral (ABM) phase. The attachment of cells
Publikováno v:
Biochemical and biophysical research communications. 292(4)
Hyaluronan, a high-molecular-weight glycosaminoglycan of cartilage, is deposited directly into the extracellular space by hyaluronan synthases, while hyaluronan catabolism is mediated by the hyaluronidases. An in vitro cell culture system has been es
Autor:
Craig A. Gough, Rajendra S. Bhatnagar
Publikováno v:
Journal of biomolecular structuredynamics. 17(3)
(Pro-Pro-Gly)10 [(PPG10)], a collagen-like polypeptide, forms a triple-helical, polyproline-II structure in aqueous solution at temperatures somewhat lower than physiological, with a melting temperature of 24.5 degrees C. In this article, we present