Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Rajendra Raghow"'
Autor:
Timothy J Garrett, Michelle A Puchowicz, Edwards A Park, Qingming Dong, Gregory Farage, Richard Childress, Joy Guingab, Claire L Simpson, Saunak Sen, Elizabeth C Brogdon, Logan M Buchanan, Rajendra Raghow, Marshall B Elam
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0294498 (2023)
BackgroundBetween 5-10% of patients discontinue statin therapy due to statin-associated adverse reactions, primarily statin associated muscle symptoms (SAMS). The absence of a clear clinical phenotype or of biomarkers poses a challenge for diagnosis
Externí odkaz:
https://doaj.org/article/e2f188c7a2cd4b38a82684bcf7f360b7
Autor:
Qingming Dong, Michael S. Kuefner, Xiong Deng, Dave Bridges, Edwards A. Park, Marshall B. Elam, Rajendra Raghow
Publikováno v:
Biology of Sex Differences, Vol 9, Iss 1, Pp 1-15 (2018)
Abstract Background Patients with metabolic syndrome, who are characterized by co-existence of insulin resistance, hypertension, hyperlipidemia, and obesity, are also prone to develop non-alcoholic fatty liver disease (NAFLD). Although the prevalence
Externí odkaz:
https://doaj.org/article/0ea7f98199934454960e629c36c71b38
Autor:
Marshall B Elam, Gipsy Majumdar, Khyobeni Mozhui, Ivan C Gerling, Santiago R Vera, Hannah Fish-Trotter, Robert W Williams, Richard D Childress, Rajendra Raghow
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181308 (2017)
Statins, the 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors, are widely prescribed for treatment of hypercholesterolemia. Although statins are generally well tolerated, up to ten percent of statin-treated patients experience myalgia sympt
Externí odkaz:
https://doaj.org/article/f656a1c7cac74a59ac6269e67cfb387b
Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR:LA-cp rat
Autor:
Marshall B. Elam, Henry G. Wilcox, Lauren M. Cagen, Xiong Deng, Rajendra Raghow, Poonam Kumar, Murray Heimberg, James C. Russell
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 12, Pp 2039-2048 (2001)
The corpulent JCR:LA-cp rat (cp/cp) is a useful model for study of the metabolic consequences of obesity and hyperinsulinemia. To assess the effect of hyperinsulinemia on VLDL secretion in this model, we measured rates of secretion of VLDL in perfuse
Externí odkaz:
https://doaj.org/article/b965049c35d04370b533667cfb56f062
Autor:
Ling Chen, Rajendra Raghow, Xing-Lin Tan, Geng Lin, Fu-Ming Zhou, Xingyong Chen, Andy Y. Shih, Francesca-Fang Liao, Wei Zheng
Publikováno v:
The American Journal of Pathology. 191:1932-1945
Age-related cerebral small-vessel disease (CSVD) is a major cause of stroke and dementia. Despite a widespread acceptance of small-vessel arteriopathy, lacunar infarction, diffuse white matter injury, and cognitive impairment as four cardinal feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d889b450dce7a0e36071d48b1ced0271
https://doi.org/10.1016/j.ajpath.2021.02.022
https://doi.org/10.1016/j.ajpath.2021.02.022
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1864:1145-1156
Lipid homeostasis is critically dependent on the liver. Hepatic genes involved in lipid biosynthesis are controlled by combinatorial actions of multiple transcription factors that include three sterol regulatory element binding proteins (SREBPs), car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e04db998103013f3377bd3f4770eaf
https://doi.org/10.1016/j.bbalip.2019.04.015
https://doi.org/10.1016/j.bbalip.2019.04.015
Autor:
Rajendra Raghow
Publikováno v:
World Journal of Diabetes
The adipose tissue homeostasis is profoundly affected by circadian rhythms of corticosteroid secretion and chronic loss of hormonal oscillations is associated with obesity. How adipose tissue differentially responds to pulsatile vs continuous presenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0151a2578cb2727d170728ad4ddd1d34
https://doi.org/10.4239/wjd.v9.i11.195
https://doi.org/10.4239/wjd.v9.i11.195
Autor:
Rajendra Raghow
Publikováno v:
World Journal of Diabetes
Patients undergoing Roux-en-Y gastric bypass (RYGB) surgery elicit striking loss of body weight. Anatomical re-structuring of the gastrointestinal (GI) tract, leading to reduced caloric intake and changes in food preference, are thought to be the pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22793ec784b510ee2323080530916df
https://doi.org/10.4239/wjd.v8.i12.484
https://doi.org/10.4239/wjd.v8.i12.484
Autor:
Robert N. O'Meally, Gipsy Majumdar, Marshall B. Elam, Robert N. Cole, Rajendra Raghow, Qingming Dong
Publikováno v:
Molecular and cellular biochemistry. 463(1-2)
Insulin stimulates de novo lipid synthesis in the liver and in cultured hepatocytes via its ability to activate sterol regulatory element-binding protein 1c (SREBP-1c). Although PI3K-AKT-mTORC1-p70S6K-signaling kinases are known to drive feed-forward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10da0ddcf0df0788c768ae11b6a1d3b3
https://pubmed.ncbi.nlm.nih.gov/31541353
https://pubmed.ncbi.nlm.nih.gov/31541353
Publikováno v:
Analytical Biochemistry. 474:25-27
We combined the TRIzol method of nucleic acid extraction with QIAamp columns to achieve coextraction of RNA and genomic DNA from peripheral blood mononuclear cells (PBMCs) and biopsied skeletal muscle, both stored at -80 °C for many months. Total RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaab7d4aca0c251a90975272fe278859
https://doi.org/10.1016/j.ab.2014.12.021
https://doi.org/10.1016/j.ab.2014.12.021