Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rajendra P. Rathnam"'
Publikováno v:
Saudi Pharmaceutical Journal, Vol 25, Iss 8, Pp 1103-1107 (2017)
The safety information on drug labels of a company marketing the same drugs in different countries is sometimes different. The aim of the present study is to understand the differences in the volume and content of safety information on the drug label
Externí odkaz:
https://doaj.org/article/15ac0ea241904857ab1b81feff980e5c
Autor:
John Spencer, Simon P. Mackay, George Owusu-Dapaah, Carol Clements, Michael P. Barrett, Rachel L. Clark, Rajendra P. Rathnam, Judith K. Huggan
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:6019-6033
A library of 1,4-benzodiazepines has been synthesised and evaluated for activity against Trypanosoma brucei, a causative parasite of Human African Trypanosomiasis (HAT). The most potent of these derivatives has an MIC value of 0.97 μM. Herein we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67cf05a47aabf66a640bc0b4a19bbf7
https://doi.org/10.1016/j.bmc.2012.08.049
https://doi.org/10.1016/j.bmc.2012.08.049
Autor:
Alan Bashall, Babur Z. Chowdhry, Rajendra P. Rathnam, Trushar Adatia, Anthony I. Mallet, John Spencer, Frank Rominger
Publikováno v:
Tetrahedron. 64:6082-6089
Air stable benzodiazepine containing palladacycles were synthesized by a C–H activation reaction and studied by mass spectrometry and X-ray crystallography. Catalytic C–H functionalizations of 1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e14ce04a3570ba9f1fd2e8ce042b93a
https://doi.org/10.1016/j.tet.2008.01.059
https://doi.org/10.1016/j.tet.2008.01.059
Publikováno v:
Future medicinal chemistry. 2(9)
1,4-benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to ‘classical’ CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f822bda84fc91becd607a7bb27517e4
https://pubmed.ncbi.nlm.nih.gov/21426139
https://pubmed.ncbi.nlm.nih.gov/21426139
Autor:
Pui Ee Wong, Alan L. Harvey, Louise Male, Simon J. Coles, Carol Clements, Simon P. Mackay, Rachel L. Clark, Michael P. Barrett, John Spencer, Rajendra P. Rathnam
Publikováno v:
Bioorganicmedicinal chemistry. 19(5)
A library of 1,4-benzodiazepines has been synthesized and evaluated against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis. Benzodiazepines possessing a P2- transporter motif were found to have MIC values as low as 0.78 μM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6caf28a33839853440eeb4b17d5e3180
https://pubmed.ncbi.nlm.nih.gov/21306904
https://pubmed.ncbi.nlm.nih.gov/21306904
Publikováno v:
ChemInform. 40
Heterocycle containing nitroaromatics were reduced by Mo(CO)(6) and DBU in EtOH under microwave irradiation within 15 min. Under the same conditions, 4-fluoronitrobenzene was reduced to 4-fluoroaniline, whereas 2-chloro-1-fluoro-4-nitrobenzene afford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e7eac57a36853e861a186bab6a9f84
https://doi.org/10.1002/chin.200911076
https://doi.org/10.1002/chin.200911076
Publikováno v:
ChemInform. 39
An ethanolic mixture of molybdenurn hexacarbonyl and DBU mediates the reduction of nitroarenes to the corresponding anilines in excellent yields in 15-30 minutes under microwave irradiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fadbd30cbd24839c7a9850eea7d38058
https://doi.org/10.1002/chin.200809080
https://doi.org/10.1002/chin.200809080
Publikováno v:
Synlett. 2007:2557-2558
An ethanolic mixture of molybdenurn hexacarbonyl and DBU mediates the reduction of nitroarenes to the corresponding anilines in excellent yields in 15-30 minutes under microwave irradiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7b487fbbf03e92e335d4de5b2415956
https://doi.org/10.1055/s-2007-986628
https://doi.org/10.1055/s-2007-986628
Autor:
Olivier Zava, Paul J. Dyson, Michael B. Hursthouse, Angela Casini, Rajendra P. Rathnam, John Spencer, Michel Pfeffer, Samantha K. Callear, Santosh K. Velhanda
Publikováno v:
Dalton Transactions. :10731
The reaction of the five- or six-membered C,N or C,S-palladacycles [(L)PdCl](2) with PTA (1,3,5-triaza-7-phosphaadamantane) led to the monomeric complexes [(L)Pd(PTA)Cl] 6a, 6b and 7 where LH= N,N-dimethyl-1-phenylmethanamine, benzyl(methyl)sulfane o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1657ad0d73a395abb90ba0bfe52603
https://doi.org/10.1039/b912096c
https://doi.org/10.1039/b912096c
Autor:
Rajendra P. Rathnam, Arun K. Kotha, Michael B. Hursthouse, Simon C. W. Richardson, Louise Male, Ali Hazrati, Mahesh Motukuri, John A. Hartley, John Spencer
Publikováno v:
Dalton Transactions. :4299
The reaction of the five-membered C,N-palladacycle [(L)PdCl](2), where LH = 1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one, with 1,2-ethanebis(diphenylphosphine), dppe, leads to the formation of the bridged palladacycle. [Pd(2)L(2)(mu-dppe)Cl(2)] 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277fb4199712c0c804dad7148c1376a3
https://doi.org/10.1039/b819061e
https://doi.org/10.1039/b819061e