Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Rajendra P. Pangeni"'
Autor:
Jessica Cohen, Annette Mathew, Kirk D. Dourvetakis, Estella Sanchez-Guerrero, Rajendra P. Pangeni, Narasimman Gurusamy, Kristina K. Aenlle, Geeta Ravindran, Assma Twahir, Dylan Isler, Sara Rukmini Sosa-Garcia, Axel Llizo, Alison C. Bested, Theoharis C. Theoharides, Nancy G. Klimas, Duraisamy Kempuraj
Publikováno v:
Cells, Vol 13, Iss 6, p 511 (2024)
Neuroinflammatory and neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the ne
Externí odkaz:
https://doaj.org/article/fa2e3f95fc5d4e478dd12972a6ec1d76
Autor:
Ting Sun, Keqiang Zhang, Wendong Li, Yunze Liu, Rajendra P. Pangeni, Aimin Li, Leonidas Arvanitis, Dan J. Raz
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Ubiquitin-specific protease 22 (USP22), a putative cancer stem cell marker, is frequently upregulated in cancers, and USP22 overexpression is associated with aggressive growth, metastasis, and therapy resistance in various human c
Externí odkaz:
https://doaj.org/article/1508023ae23447f0ae85d1adae5fcd9e
Autor:
Rajendra P. Pangeni, Ivonne Olivaries, David Huen, Vannessa C. Buzatto, Timothy P. Dawson, Katherine M. Ashton, Charles Davis, Andrew R. Brodbelt, Michael D. Jenkinson, Ivan Bièche, Lu Yang, Farida Latif, John L. Darling, Tracy J. Warr, Mark R. Morris
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Brain metastases comprise 40% of all metastatic tumours and breast tumours are among the tumours that most commonly metastasise to the brain, the role that epigenetic gene dysregulation plays in this process is not well understood. We carrie
Externí odkaz:
https://doaj.org/article/08b2c9c30d794134830e32dbafb71118
Autor:
Keqiang Zhang, Yuelong Ma, Yuming Guo, Ting Sun, Jun Wu, Rajendra P. Pangeni, Min Lin, Wendong Li, David Horne, Dan J. Raz
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 304-316 (2020)
To overcome poor pharmacokinetics and toxicity of triptolide (TPL), a natural compound that exhibits potent anticancer activities, we developed a novel antibody-drug conjugate (ADC) to specifically deliver TPL to epidermal growth factor receptor (EGF
Externí odkaz:
https://doaj.org/article/39c1e2d20ed54675bd83dba83c5ca446
Autor:
Rajendra P. Pangeni, Zhou Zhang, Angel A. Alvarez, Xuechao Wan, Namratha Sastry, Songjian Lu, Taiping Shi, Tianzhi Huang, Charles X. Lei, C. David James, John A. Kessler, Cameron W. Brennan, Ichiro Nakano, Xinghua Lu, Bo Hu, Wei Zhang, Shi-Yuan Cheng
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 432-448 (2018)
Glioma stem cells (GSCs), a subpopulation of tumor cells, contribute to tumor heterogeneity and therapy resistance. Gene expression profiling classified glioblastoma (GBM) and GSCs into four transcriptomically-defined subtypes. Here, we determined th
Externí odkaz:
https://doaj.org/article/9f203d1a69c64cac8045dc5a3fdc5f92
Autor:
Tianzhi Huang, Angel A. Alvarez, Rajendra P. Pangeni, Craig M. Horbinski, Songjian Lu, Sung-Hak Kim, C. David James, Jeffery J. Raizer, John A. Kessler, Cameron W. Brenann, Erik P. Sulman, Gaetano Finocchiaro, Ming Tan, Ryo Nishikawa, Xinghua Lu, Ichiro Nakano, Bo Hu, Shi-Yuan Cheng
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Glioblastoma (GBM) is classified as proneural (PN), neural, mesenchymal (MES) and classical GBM. Here the authors show that Wnt signalling, miR-125b and miR-20b establish a regulatory circuitry including FZD6 which distinguishes PN from the MES subty
Externí odkaz:
https://doaj.org/article/b31366b622e74db0ba44d725ba959681
Autor:
Dan J. Raz, Ming Gao, Isaac K. Nardi, Jami Wang, Jun Wu, Melissa Bonner, Lu Yang, Rajendra P. Pangeni, Jinhui Wang, Keqiang Zhang, Xinwei Yun
Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma. This study investigated the association and impact of the ubiquitin-specific peptidase 22 (USP22),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::270f56f1a6a43439d331a62a5e8c40a2
https://doi.org/10.1158/1541-7786.c.6541216
https://doi.org/10.1158/1541-7786.c.6541216
Autor:
Dan J. Raz, Ming Gao, Isaac K. Nardi, Jami Wang, Jun Wu, Melissa Bonner, Lu Yang, Rajendra P. Pangeni, Jinhui Wang, Keqiang Zhang, Xinwei Yun
Immunofluorescence of CD133 and USP22/H2Bub1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152deddde1c364dd16586bf39c262874
https://doi.org/10.1158/1541-7786.22515907.v1
https://doi.org/10.1158/1541-7786.22515907.v1
Autor:
Dan J. Raz, Leonidas Arvanitis, Shyambabu Chaurasiya, Yuming Guo, Yong Du, Wendong Li, Jun Wu, Rajendra P. Pangeni, Keqiang Zhang, Ting Sun
Potential roles of euchromatic histone methyltransferase 2 (EHMT2 or G9a) in invasion and metastasis are not well understood in non–small cell lung cancer (NSCLC). Here, we investigated the effect and underlying mechanisms of G9a and therapeutic im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5582dbe38581921d4d27c564d0df3283
https://doi.org/10.1158/1541-7786.c.6545039.v1
https://doi.org/10.1158/1541-7786.c.6545039.v1
Autor:
Dan J. Raz, Leonidas Arvanitis, Shyambabu Chaurasiya, Yuming Guo, Yong Du, Wendong Li, Jun Wu, Rajendra P. Pangeni, Keqiang Zhang, Ting Sun
Figure S1. G9a silencing suppressed cell proliferation in A549 and H1299 NSCLCs Figure S2. Cell migration and invasion was suppressed in NSCLCs treated by G9a inhibitor UNC0638 Figure S3. G9a overexpression increased cell proliferation in NSCLCs Figu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270d03ebe8b49c43093b748151df6e07
https://doi.org/10.1158/1541-7786.22526243.v1
https://doi.org/10.1158/1541-7786.22526243.v1