Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Rajendra, Gurung"'
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Samuel J. Rodgers, Lisa M. Ooms, Viola M. J. Oorschot, Ralf B. Schittenhelm, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J. Eramo, Absorn Sriratana, Clare G. Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E. Abud, Georg Ramm, Antonella Papa, Andrew M. Ellisdon, Roger J. Daly, Catriona A. McLean, Christina A. Mitchell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endoso
Externí odkaz:
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Autor:
Jacob Creswell, Zhi Zhen Qin, Rajendra Gurung, Bikash Lamichhane, Deepak Kumar Yadav, Mohan Kumar Prasai, Nirmala Bista, Lal Mani Adhikari, Bishwa Rai, Santat Sudrungrot
Publikováno v:
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 14, Iss , Pp 1-6 (2019)
Setting: The introduction of Xpert MTB/RIF (Xpert) and renewed interest in chest x-ray (CXR) for tuberculosis testing has provided additional choices to the smear-based diagnostic algorithms used by TB programs previously. More programmatic data is n
Externí odkaz:
https://doaj.org/article/6f32d7e0aa214c6993ee0e76c975a29f
Autor:
Dristi Halwai, Rajendra Gurung, Nimesh Poudyal, Dharanidhar Baral, Shyamal Kumar Bhattacharya
Publikováno v:
Tropical Medicine and Health, Vol 46, Iss 1, Pp 1-4 (2018)
Abstract Background Emergence of multi-drug-resistant tuberculosis is a serious challenge for successful global tuberculosis control. Early diagnosis of drug-resistant tuberculosis by direct nitrate reductase assay (NRA) aids in appropriate treatment
Externí odkaz:
https://doaj.org/article/65f4b3703b44418788cc151aa651b10a
Autor:
Randini Nanayakkara, Rajendra Gurung, Samuel J. Rodgers, Matthew J. Eramo, Georg Ramm, Christina A. Mitchell, Meagan J. McGrath
Publikováno v:
Autophagy. :1-18
Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained. Lysosome repopulation ensures sustained autophagy function, a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bfd050106eeb659a90ed23db3ca28a
https://doi.org/10.1080/15548627.2022.2128019
https://doi.org/10.1080/15548627.2022.2128019
Autor:
Elizabeth M. Davies, Rajendra Gurung, Kai Qin Le, Katherine T. T. Roan, Richard P. Harvey, Geraldine M. Mitchell, Quenten Schwarz, Christina A. Mitchell
Publikováno v:
Science Advances. 9
Dynamic positioning of endothelial tip and stalk cells, via the interplay between VEGFR2 and NOTCH signaling, is essential for angiogenesis. VEGFR2 activates PI3K, which phosphorylates PI(4,5)P 2 to PI(3,4,5)P 3 , activating AKT; however, PI3K/AKT do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc4ba1a101bfabcab36ceed205fad802
https://doi.org/10.1126/sciadv.add6911
https://doi.org/10.1126/sciadv.add6911
Autor:
Samuel J Rodgers, Emily I Jones, Senthil Arumugam, Sabryn A Hamila, Jill Danne, Rajendra Gurung, Matthew J Eramo, Randini Nanayakkara, Georg Ramm, Meagan J McGrath, Christina A Mitchell
Publikováno v:
The EMBO Journal. 41
Autophagy depends on the repopulation of lysosomes to degrade intracellular components and recycle nutrients. How cells co-ordinate lysosome repopulation during basal autophagy, which occurs constitutively under nutrient-rich conditions, is unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600e78f8e92a9e85bf84fc9297ea0175
https://doi.org/10.15252/embj.2021110398
https://doi.org/10.15252/embj.2021110398
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Matthew J. Eramo, Helen E. Abud, Lisa M Ooms, Samuel J. Rodgers, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie K. Rynkiewicz, Absorn Sriratana, Georg Ramm, Genevieve Kerr, Catriona McLean, Viola Oorschot, Ralf B. Schittenhelm, Sherene Loi, Andrew M. Ellisdon, Rajendra Gurung, Christina Anne Mitchell, Clare G Fedele, Antonella Papa, Roger J. Daly, Franco Caramia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2e2bc82108595261d2a16543c76a05
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Publikováno v:
Journal of Laboratory Physicians, Vol 5, Iss 01, Pp 17-20 (2013)
Context: Urinary tract infection (UTI) is one of the major health problems. Urine culture is considered as a gold standard method for the diagnosis of UTI. But, improper sample collection can lead to contamination with normal urogenital flora. Use of
Externí odkaz:
https://doaj.org/article/8d7e27a4dec14c8291bbe67157c2aa55
Publikováno v:
Autophagy. 17:1287-1289
Autophagic lysosome reformation (ALR) recycles autolysosome membranes formed during autophagy, to make lysosomes and is essential for continued autophagy function. Localized membrane remodeling on autolysosomes leads to the extension of reformation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb49396f5e7df492348fa2d7caa68c7a
https://doi.org/10.1080/15548627.2021.1916195
https://doi.org/10.1080/15548627.2021.1916195
Publikováno v:
The Journal of Clinical Investigation
The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic lysosome reformation (ALR), a lysosome recycling pathway, in muscle. INPP5K hydrolyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de82a3c063c7f16d4d9ae2c2223f4142
https://pubmed.ncbi.nlm.nih.gov/33119550
https://pubmed.ncbi.nlm.nih.gov/33119550