Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rajender, Vemula"'
Publikováno v:
Green Synthesis and Catalysis, Vol 3, Iss 2, Pp 156-161 (2022)
The full account of our development of a de novo asymmetric total synthesis of (+)-monanchorin has been reported. The optimized synthesis provided access to either enantiomer of the guanidine alkaloid natural product in nine steps from the commodity
Externí odkaz:
https://doaj.org/article/412584c311ea43639f438b2aff23ca48
Publikováno v:
ACS Infectious Diseases. 6:1323-1331
The prospect of ever increasing antibiotic resistance eroding currently available treatment options for bacterial infections underscores the need to continue to identify new antibiotics, preferably those that act on novel targets or with novel mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3693dd4932733f149d3b250e99657a50
https://doi.org/10.1021/acsinfecdis.0c00025
https://doi.org/10.1021/acsinfecdis.0c00025
Autor:
Yu Li, Rajender Vemula, Qi Zhang, Shinji Fukuda, George A. O'Doherty, Bulan Wu, Zachary M. Sandusky, Deborah A. Lannigan, Mingzong Li
Publikováno v:
Organic Letters. 22:1448-1452
An asymmetric synthesis of two analogues of SL0101 (1) has been achieved. The effort is aimed at the discovery of inhibitors of the p90 ribosomal S6 kinase (RSK) with improved bioavailability. The route relies upon the use of the Taylor catalyst to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b998bf25c939ed6e1b127a9f5c5965
https://doi.org/10.1021/acs.orglett.0c00042
https://doi.org/10.1021/acs.orglett.0c00042
Publikováno v:
Organic Letters. 19:3883-3886
The previously unknown 5-spirocyclohexylisoimidazole has been made efficiently and simply by reaction of ammonia, glyoxal hydrate, and cyclohexanone. It is a very useful precursor for the diastereocontrolled synthesis of many C2-symmetric 1,2-diamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb25809c3cf38a0bf84219007ac962d6
https://doi.org/10.1021/acs.orglett.7b01768
https://doi.org/10.1021/acs.orglett.7b01768
Autor:
Charles K, Perry, Austen B, Casey, Daniel E, Felsing, Rajender, Vemula, Mehreen, Zaka, Noah B, Herrington, Meng, Cui, Glen E, Kellogg, Clinton E, Canal, Raymond G, Booth
Publikováno v:
Bioorganicmedicinal chemistry. 28(3)
The serotonin 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1e5345e0438fe2f41e5bdc69b8d4543
https://pubmed.ncbi.nlm.nih.gov/31882369
https://pubmed.ncbi.nlm.nih.gov/31882369
Autor:
Raymond G. Booth, Mehreen Zaka, Charles K. Perry, Daniel E. Felsing, Glen E. Kellogg, Meng Cui, Noah B. Herrington, Rajender Vemula, Clinton E. Canal, Austen B. Casey
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115262
The serotonin 5-HT7 G protein-coupled receptor (GPCR) is a proposed pharmacotherapeutic target for a variety of central and peripheral indications, albeit, there are no approved drugs selective for binding 5-HT7. We previously reported that a lead an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f14acd52f9611f26364f7fb8193bd0
https://doi.org/10.1016/j.bmc.2019.115262
https://doi.org/10.1016/j.bmc.2019.115262
Autor:
Yue Liu, Rajender Vemula, Clinton E. Canal, JodiAnne T. Wood, Wanying Zhu, Charles K. Perry, Daniel E. Felsing, Raymond G. Booth
Publikováno v:
ACS Chemical Neuroscience. 6:1259-1270
Stereotypy (e.g., repetitive hand waving) is a key phenotype of autism spectrum disorder, Fragile X and Rett syndromes, and other neuropsychiatric disorders, and its severity correlates with cognitive and attention deficits. There are no effective tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed64a9eb63f2089455e7adeeee0eb7e3
https://doi.org/10.1021/acschemneuro.5b00099
https://doi.org/10.1021/acschemneuro.5b00099
Publikováno v:
Organic letters. 19(14)
The previously unknown 5-spirocyclohexylisoimidazole has been made efficiently and simply by reaction of ammonia, glyoxal hydrate, and cyclohexanone. It is a very useful precursor for the diastereocontrolled synthesis of many C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8462cb2b2497bcd0f0e5d89fea439928
https://pubmed.ncbi.nlm.nih.gov/28696724
https://pubmed.ncbi.nlm.nih.gov/28696724
Autor:
Qi Zhang, Roman M. Mrozowski, Bulan Wu, Deborah A. Lannigan, Rajender Vemula, Zachary M. Sandusky, George A. O'Doherty
Publikováno v:
Organic Letters
In an effort to improve upon the in vivo half-life of the known ribosomal s6 kinase (RSK) inhibitor SL0101, C4″-amide/C6″-alkyl substituted analogues of SL0101 were synthesized and evaluated in cell-based assays. The analogues were prepared using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583c4ee1be863da9931d2c4e0a6626a9
http://europepmc.org/articles/PMC4251525
http://europepmc.org/articles/PMC4251525
Publikováno v:
Organic Letters. 17:1621-1623
Lithiation of α-C-H groups in organic substrates by RLi or R2NLi followed by silylation with R'3SiCl generally provides analogous products regardless of the R' group of R'3SiCl. A striking exception using 3,4-benzothiophane as substrate depending on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ffa7a5f8a2af4e47a44e56e06e60ba
https://doi.org/10.1021/acs.orglett.5b00521
https://doi.org/10.1021/acs.orglett.5b00521