Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Rajeev Ramanan"'
Autor:
Sodiq O. Waheed, Rajeev Ramanan, Shobhit S. Chaturvedi, Nicolai Lehnert, Christopher J. Schofield, Christo Z. Christov, Tatyana G. Karabencheva-Christova
Publikováno v:
ACS Central Science, Vol 6, Iss 5, Pp 795-814 (2020)
Externí odkaz:
https://doaj.org/article/671b2154f1274f919cf4c7bb1df20bfe
Autor:
Shobhit S. Chaturvedi, Simahudeen Bathir Jaber Sathik Rifayee, Rajeev Ramanan, Joel A. Rankin, Jian Hu, Robert P. Hausinger, Christo Z. Christov
Publikováno v:
Physical Chemistry Chemical Physics. 25:13772-13783
Computational demonstration of applying an external electric field to modify the reaction ratio of ethylene-forming enzyme in favor of ethylene generation from 2OG.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4a76c335d3a058c5f99d9d49006db61
https://doi.org/10.1039/d3cp01899g
https://doi.org/10.1039/d3cp01899g
Publikováno v:
ACS Catalysis. 11:1578-1592
The ethylene-forming enzyme (EFE) is a non-heme Fe(II), 2-oxoglutarate (2OG), and l-arginine (l-Arg)-dependent oxygenase that catalyzes dual reactions: the generation of ethylene from 2OG and the C...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06965a4d276a924898b9a052275dfef6
https://doi.org/10.1021/acscatal.0c03349
https://doi.org/10.1021/acscatal.0c03349
Autor:
Nicolai Lehnert, Rajeev Ramanan, Shobhit S. Chaturvedi, Tatyana G. Karabencheva-Christova, Christo Z. Christov, Christopher J. Schofield, Sodiq O. Waheed
Publikováno v:
ACS Central Science, Vol 6, Iss 5, Pp 795-814 (2020)
ACS Central Science
ACS Central Science
AlkB and its human homologue AlkBH2 are Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases that repair alkylated DNA bases occurring as a consequence of reactions with mutagenic agents. We used molecular dynamics (MD) and combined quantum mechanic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72917ebb97594e18621a691c5889bcfe
https://doaj.org/article/671b2154f1274f919cf4c7bb1df20bfe
https://doaj.org/article/671b2154f1274f919cf4c7bb1df20bfe
Autor:
Nicolai Lehnert, Christopher J. Schofield, Christo Z. Christov, Shobhit S. Chaturvedi, Rajeev Ramanan, Tatyana G. Karabencheva-Christova
Publikováno v:
Chemical Science
The Nε-methyl lysine status of histones is important in the regulation of eukaryotic transcription. The Fe(ii) and 2-oxoglutarate (2OG) -dependent JmjC domain enzymes are the largest family of histone Nε-methyl lysine demethylases (KDMs). The human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564b1fc1652791eeab69afbab6a13276
https://pubmed.ncbi.nlm.nih.gov/34094257
https://pubmed.ncbi.nlm.nih.gov/34094257
Publikováno v:
Journal of the American Chemical Society. 140:13350-13359
The manuscript studies the enantioselectivity and stereoselectivity of Diels-Alder (DA) cycloadditions between cyclopentadiene (CPD) and a variety of dienophiles (ranging from halo-ethenes to cyano-ethenes), under oriented external electric fields (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdef25b904c8256523d20474a18cf2f1
https://doi.org/10.1021/jacs.8b08233
https://doi.org/10.1021/jacs.8b08233
Publikováno v:
Journal of the American Chemical Society. 140:4354-4362
Oriented external electric fields (OEEFs) are potent effectors of chemical change and control. We show that the Menshutkin reaction, between substituted pyridines and methyl iodide, can be catalyzed/inhibited at will, by just flipping the orientation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f6e7330d6a3c75a969c0f7915efc69
https://doi.org/10.1021/jacs.8b00192
https://doi.org/10.1021/jacs.8b00192
Publikováno v:
Angewandte Chemie (International ed. in English). 59(20)
This contribution follows the recent remarkable catalysis observed by Groves et al. in hydrogen-abstraction reactions by a) an oxoferryl porphyrin radical-cation complex [Por⋅+ FeIV (O)Lax ] and b) a hydroxoiron porphyrazine ferric complex [PyPzFeI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00700efed9bc3b9adedb90c89c7ce4f5
https://pubmed.ncbi.nlm.nih.gov/32097514
https://pubmed.ncbi.nlm.nih.gov/32097514
Autor:
Rajeev Ramanan, Tatyana G. Karabencheva-Christova, Christopher J. Schofield, Shobhit S. Chaturvedi, Christo Z. Christov, Nicolai Lehnert
Publikováno v:
ACS Catalysis
PHF8 (KDM7B) is a human non-heme 2-oxoglutarate (2OG) JmjC domain oxygenase that catalyzes the demethylation of the di/mono-Ne-methylated K9 residue of histone H3. Altered PHF8 activity is linked to genetic diseases and cancer; thus, it is an interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a5de2cbd00f21f20e68f5b875fd018
https://pubmed.ncbi.nlm.nih.gov/31976154
https://pubmed.ncbi.nlm.nih.gov/31976154
Autor:
Shobhit S, Chaturvedi, Rajeev, Ramanan, Sodiq O, Waheed, Tatyana G, Karabencheva-Christova, Christo Z, Christov
Publikováno v:
Advances in protein chemistry and structural biology. 117
The demethylation of lysine residues of histone proteins is a key epigenetic mechanism in cells. The enzymes that catalyze these processes are called histone demethylases (KDMs). The largest family of KDMs is the Jumonji C (JmjC) domain-containing en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::718a2a46a1cedc7f73aa44082f947226
https://pubmed.ncbi.nlm.nih.gov/31564306
https://pubmed.ncbi.nlm.nih.gov/31564306