Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Rajeev B. Tajhya"'
Autor:
Ralf Bergmann, Manja Kubeil, Kristof Zarschler, Sandeep Chhabra, Rajeev B. Tajhya, Christine Beeton, Michael W. Pennington, Michael Bachmann, Raymond S. Norton, Holger Stephan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The peptide HsTX1[R14A] is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, which is a highly promising target for the treatment of autoimmune diseases and other conditions. In order to assess the biodistribution
Externí odkaz:
https://doaj.org/article/df49b90ff84b43d9acf32897f9f258e4
Autor:
Michael W. Pennington, Shih Chieh Chang, Satendra Chauhan, Redwan Huq, Rajeev B. Tajhya, Sandeep Chhabra, Raymond S. Norton, Christine Beeton
Publikováno v:
Marine Drugs, Vol 13, Iss 1, Pp 529-542 (2015)
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM. We developed an analog of this peptide, ShK-186,
Externí odkaz:
https://doaj.org/article/c1c30af770e04c0a8a922513e4d0220d
Autor:
Satendra Chauhan, Sandeep Chhabra, Rajeev B. Tajhya, Redwan Huq, Christine Beeton, Raymond S. Norton, Michael W. Pennington, Shihchieh Jeff Chang
Publikováno v:
Marine Drugs
Marine Drugs, Vol 13, Iss 1, Pp 529-542 (2015)
Volume 13
Issue 1
Pages 529-542
Marine Drugs, Vol 13, Iss 1, Pp 529-542 (2015)
Volume 13
Issue 1
Pages 529-542
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM. We developed an analog of this peptide, ShK-186,
Autor:
Raymond S. Norton, Michael W. Pennington, Redwan Huq, Elizabeth J. Gehrmann, Mustafa A. Atik, Christine Beeton, Mark R. Tanner, Kathia E. Rodarte, Rajeev B. Tajhya
Effector memory T lymphocytes (TEM cells) that lack expression of CCR7 are major drivers of inflammation in a number of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. The Kv1.3 potassium channel is a key regulator of CCR7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4aa5b79f727fcf959f72faa4d9a4b7
https://europepmc.org/articles/PMC5484050/
https://europepmc.org/articles/PMC5484050/
Publikováno v:
Methods in Molecular Biology ISBN: 9781493968619
Matrix metalloproteinases (MMPs) represent more than 20 zinc-containing endopeptidases that cleave internal peptide bonds, leading to protein degradation. They play a critical role in many physiological cell functions, including tissue remodeling, em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed75a1ed8b113a057a72899dbb64c17
https://europepmc.org/articles/PMC5465868/
https://europepmc.org/articles/PMC5465868/
Autor:
Rajeev B. Tajhya, Robia G. Pautler, Taeko Inoue, Fatima S. Khan, Errol L. G. Samuel, David B. Corry, Christine Beeton, Lizanne G. Nilewski, Tom V. Lee, Paul Porter, Rutvik S. Patel, William K.A. Sikkema, Mark R. Tanner, Redwan Huq, James M. Tour
Publikováno v:
Scientific Reports
Autoimmune diseases mediated by a type of white blood cell—T lymphocytes—are currently treated using mainly broad-spectrum immunosuppressants that can lead to adverse side effects. Antioxidants represent an alternative approach for therapy of aut
Autor:
Redwan Huq, Rajeev B. Tajhya, Gyorgy Panyi, Teresina Laragione, Christine Beeton, Pércio S. Gulko, Mark R. Tanner, Zoltán Petho
Publikováno v:
Arthritis Research & Therapy
Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA-FLS) contribute to joint inflammation and damage characteristic of the disease. RA-FLS express KCa1.1 (BK, Slo1, MaxiK, KCNMA1) as their major plasma membrane potassium channel. Blocking
Publikováno v:
Scientific Reports
Botulinum neurotoxins (BoNTs) are the most toxic substances known. BoNT intoxicates cells in a highly programmed fashion initiated by binding to the cell surface, internalization and enzymatic cleavage of substrate, thus, inhibiting synaptic exocytos
Autor:
Pércio S. Gulko, Mark R. Tanner, Christine Beeton, Michael W. Pennington, Redwan Huq, Rajeev B. Tajhya, Teresina Laragione
Publikováno v:
Toxicon. 149:86
Autor:
Satendra Chauhan, Michael W. Pennington, Christine Beeton, Rosendo Estrada, Redwan U. Huq, Rajeev B. Tajhya
Publikováno v:
Peptides 2015, Proceedings of the 24th American Peptide Symposium.
With more than 80 different types of autoimmune disorders affecting all organ systems in the human body, finding a drug which would treat patients at the root cause of these diseases has been a quest of our mutual labs for the past two decades. These