Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Rajeev, Saggar"'
Autor:
Dave Singh, Tuan Nguyen, Jacky Woo, Rajeev Saggar, Nathan D Pfeifer, David A Lombardi, Brett Haumann, John Belperio, Maxim Bogus, Valentyn Moskalenko, David L Bourdet, Elad Kaufman, Corbin G Thompson, Edmund J Moran
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Background The inhaled lung-selective pan-Janus kinase inhibitor nezulcitinib had favourable safety and potential efficacy signals in part 1 of a phase 2 trial in patients with severe COVID-19, supporting progression to part 2.Methods Part 2 was a ra
Externí odkaz:
https://doaj.org/article/905da654e8a64ea59f91db7bc7d56b1d
Autor:
Thomas Bertero, Yu Lu, Sofia Annis, Andrew Hale, Balkrishen Bhat, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Sara O. Vargas, Brian B. Graham, Rahul Kumar, Stephen M. Black, Sohrab Fratz, Jeffrey R. Fineman, James D. West, Kathleen J. Haley, Aaron B. Waxman, B. Nelson Chau, Katherine A. Cottrill, Stephen Y. Chan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/f75ae1b920ed4388b4b98edd05c4de18
Autor:
Rajeev Saggar, Paresh C. Giri, Chunqin Deng, Dana Johnson, Mary K. McCloy, Lloyd Liang, Faisal Shaikh, Jason Hong, Richard N. Channick, Shelley S. Shapiro, Joseph P. Lynch, John A. Belperio, Samuel S. Weigt, Allison L. Ramsey, David J. Ross, David M. Sayah, Michael Y. Shino, Ariss Derhovanessian, Alexander E. Sherman, Rajan Saggar
Publikováno v:
Pulmonary Circulation, Vol 11 (2021)
The association of autoimmune disease (AI) with transplant-free survival in the setting of severe Group 3 pulmonary hypertension and extensive pulmonary fibrosis remains unclear. We report cases of severe pulmonary hypertension (mean pulmonary artery
Externí odkaz:
https://doaj.org/article/de848169b58d43ad9c6dc063d0502e7c
Autor:
Thomas Bertero, Katherine A. Cottrill, Yu Lu, Christina M. Haeger, Paul Dieffenbach, Sofia Annis, Andrew Hale, Balkrishen Bhat, Vivek Kaimal, Ying-Yi Zhang, Brian B. Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Stephen M. Black, Sohrab Fratz, Jeffrey R. Fineman, Sara O. Vargas, Kathleen J. Haley, Aaron B. Waxman, B. Nelson Chau, Laura E. Fredenburgh, Stephen Y. Chan
Publikováno v:
Cell Reports, Vol 13, Iss 5, Pp 1016-1032 (2015)
Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins. We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and pervasive processes that promote PH. In multiple pulmonary vascular c
Externí odkaz:
https://doaj.org/article/f5da7c8f7754420ab4de6ee73b9f1bf3
Autor:
Kevin White, Yu Lu, Sofia Annis, Andrew E Hale, B Nelson Chau, James E Dahlman, Craig Hemann, Alexander R Opotowsky, Sara O Vargas, Ivan Rosas, Mark A Perrella, Juan C Osorio, Kathleen J Haley, Brian B Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Omar F Khan, Andrew Bader, Bernadette R Gochuico, Majed Matar, Kevin Polach, Nicolai M Johannessen, Haydn M Prosser, Daniel G Anderson, Robert Langer, Jay L Zweier, Laurence A Bindoff, David Systrom, Aaron B Waxman, Richard C Jin, Stephen Y Chan
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 6, Pp 695-713 (2015)
Abstract Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies in v
Externí odkaz:
https://doaj.org/article/2ba2fa97eac5474ab7e2db24f409a724
Autor:
Steve Tseng, Nafis Shamsid-Deen, Ramachandra Sista, Sarika Savajiyani, Kurt Olson, Tony Hodges, Rajeev Saggar
Publikováno v:
Chest. 157:e161-e164
Case Presentation A 75-year-old man was referred to our institution for worsening dyspnea, decreased activity tolerance, myalgias, and an increase in oxygen requirement. Nine months before the initial referral, the patient presented to an outside hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bd57ed56c2e5434182c4fbd794cd236
https://doi.org/10.1016/j.chest.2019.11.012
https://doi.org/10.1016/j.chest.2019.11.012
Autor:
Richard N. Channick, Faisal Shaikh, Rajan Saggar, Zafia Anklesaria, Tasneam Shagroni, Michael J. Ryan, Eduardo Bossone, Luna Gargani, Rajeev Saggar
Publikováno v:
J Scleroderma Relat Disord
In general, pulmonary vascular disease has important negative prognostic implications, regardless of the associated condition or underlying mechanism. In this regard, systemic sclerosis is of particular interest as it is the most common connective ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dd6c0f10262a784f47dc296a402e42
https://doi.org/10.1177/2397198319851653
https://doi.org/10.1177/2397198319851653
Autor:
Antonello D’Andrea, Anna Agnese Stanziola, Rajan Saggar, Rajeev Saggar, Simona Sperlongano, Marianna Conte, Michele D’Alto, Francesco Ferrara, Luna Gargani, Patrizio Lancellotti, Eduardo Bossone, Robert Naeije, William F. Armstrong, Theodore John Kolias, Luigi Caliendo, Rosangela Cocchia, Rodolfo Citro, Michele Bellino, Ilaria Radano, Antonio Cittadini, Paola Argiento, Andreina Carbone, Santo Dellegrottaglie, Nicola De Luca, Montuori Maria Grazia, Francesco Rozza, Valentina Russo, Giovanni Di Salvo, Stefano Ghio, Ekkerard Grunig, Alberto Marra, Marco Guazzi, Francesco Bandera, Valentina Labate, André La Gerche, Giuseppe Limongelli, Giuseppe Pacileo, Marina Verrengia, Jaroslaw D. Kasprzak, Karina Wierzbowska Drabik, Gabor Kovacs, Antonella Moreo, Francesca Casadei, Benedetta De Chiara, Ellen Ostenfeld, Francesco Pieri, Lorenza Pratali, Christine Selton-Suty, Olivier Huttin, Clément Venner, Walter Serra, Anna Stanziola, Maria Martino, Giovanna Caccavo, István Szabó, Albert Varga, Gergely Agoston, Darmien Voilliot, Olga Vriz, Domenico Galzerano, Marco Scalese, Luca Carannante
Publikováno v:
Chest. 155:297-306
Background The most important determinant of long-term survival in patients with idiopathic pulmonary fibrosis is the right ventricular (RV) adaptation to the increased pulmonary vascular resistance. Our aim was to explore RV contractile reserve duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c07dd997bb4bdc97822ba92372d86ae
https://doi.org/10.1016/j.chest.2018.11.015
https://doi.org/10.1016/j.chest.2018.11.015
Autor:
Valentyn Moskalenko, Nathan D. Pfeifer, Brett Haumann, Edmund J. Moran, Elad Kaufman, Glenn Crater, David A. Lombardi, David L. Bourdet, RW Lord, Ashley Woodcock, Jacky Woo, Dave Singh, Maxim Bogus, Tuan Nguyen, Rajeev Saggar, Emily Y. Weng
BackgroundLung-targeted anti-inflammatory therapy could potentially improve outcomes in patients with COVID-19. The novel inhaled pan-Janus kinase (JAK) inhibitor TD-0903 was designed to optimise delivery to the lungs while limiting systemic exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40423d33da822e5548c57baa4f6ff857
https://doi.org/10.1101/2021.03.09.21252944
https://doi.org/10.1101/2021.03.09.21252944
Publikováno v:
Heart Failure Clinics. 14:327-331
Despite advances in targeted medical therapy, pulmonary arterial hypertension (PAH) remains a fatal disease because of progressive right ventricular dysfunction. For patients who are refractory to medical therapy, heart-lung and lung transplantation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06ce64eb88bb6f4e9c1c9b1cfa8fe9af
https://doi.org/10.1016/j.hfc.2018.02.007
https://doi.org/10.1016/j.hfc.2018.02.007