Výsledky vyhledávání - "Rajee Antony"

Supplementary Methods, Tables 1 - 9, Figures 1 - 8 from Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer

Autor: Levi A. Garraway, José Baselga, Maurizio Scaltriti, Pau Castel, Mahmoud Ghandi, Flora Luo, Daniel J. Treacy, Pedram Razavi, Rajee Antony, Xiuning Le

Supplementary Methods, Tables 1 - 9, Figures 1 - 8. Supplementary Table 1. Functional classification for validated genes. Supplementary Table 2. Validated 43 candidate genes' genetic alteration status in the invasive breast cancer (TCGA) database. Su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f022893c11b83a89ff5306c7529365
https://doi.org/10.1158/2159-8290.22531055

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Supplementary Figure Legends from C-RAF Mutations Confer Resistance to RAF Inhibitors

Autor: Levi A. Garraway, Allison M. Sawyer, Caroline M. Emery, Rajee Antony

Supplementary Figure Legends - PDF file 92K, Supplementary figure legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf849cacb0134a210ed0112d4f20fef
https://doi.org/10.1158/0008-5472.22397753.v1

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Supplementary Material from C-RAF Mutations Confer Resistance to RAF Inhibitors

Autor: Levi A. Garraway, Allison M. Sawyer, Caroline M. Emery, Rajee Antony

Supplementary Material - PDF file 1876K, Supplementary Figure S1. Characterization of mutants obtained from B-RAFV600E random mutagenesis screens Supplementary Figure S2. Biochemical characterization of C-RAF resistance alleles Supplementary Figure S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a14d865d0ed8e511ce0839b53cf3143
https://doi.org/10.1158/0008-5472.22397750.v1

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Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer

Autor: Daniel J. Treacy, Flora Luo, Maurizio Scaltriti, Xiuning Le, Pedram Razavi, José Baselga, Rajee Antony, Pau Castel, Mahmoud Ghandi, Levi A. Garraway

Publikováno v: Cancer Discovery. 6:1134-1147

PIK3CA (which encodes the PI3K alpha isoform) is the most frequently mutated oncogene in breast cancer. Small-molecule PI3K inhibitors have shown promise in clinical trials; however, intrinsic and acquired resistance limits their utility. We used a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068ec969f53e32b3571441bc81a0bef8
https://doi.org/10.1158/2159-8290.cd-16-0305

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Neuroprotectin D1 Induces Dephosphorylation of Bcl-xL in a PP2A-dependent Manner during Oxidative Stress and Promotes Retinal Pigment Epithelial Cell Survival

Autor: Nicolas G. Bazan, Rajee Antony, Walter J. Lukiw

Publikováno v: Journal of Biological Chemistry. 285:18301-18308

Retinal pigment epithelial (RPE) cell integrity is critical for the survival of photoreceptor cells. Bcl-x(L) is a major anti-apoptotic Bcl-2 protein required for RPE cell survival, and phosphorylation of Bcl-x(L) at residue Ser-62 renders this prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db159fe020b77b365fff60912b9b6b4
https://doi.org/10.1074/jbc.m109.095232

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Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils

Autor: Makoto Arita, Rajee Antony, Charles N. Serhan, Nicos A. Petasis, Victor L. Marcheselli, Pranab K. Mukherjee, Song Hong, Nicolas G. Bazan, Kristopher G. Sheets, Jeremy W. Winkler

Publikováno v: Prostaglandins, leukotrienes, and essential fatty acids. 82(1)

Retinal pigment epithelial (RPE) cells, derived from the neuroectoderm, biosynthesize the novel lipid mediator neuroprotectin D1 (NPD1) from docosahexaenoic acid (DHA) in response to oxidative stress or to neurotrophins, and in turn, elicits cytoprot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b2b71524e45231a02bd853f1cf3eb7
https://pubmed.ncbi.nlm.nih.gov/19931440

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Neuroprotectin D1 Modulates Bcl‐xL Phosphorylation during Oxidative Stress in Retinal Pigment Epithelial Cells

Autor: Nicolas G. Bazan, Rajee Antony

Publikováno v: The FASEB Journal. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39ab6e5dae89e6bf06401b6856ce5690
https://doi.org/10.1096/fasebj.23.1_supplement.526.14

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Cis-regulatory organization of the Pax6 gene in the ascidian Ciona intestinalis

Autor: Vera C. Fonseca, Steven Q. Irvine, Rajee Antony, Michael A. Zompa

The Pax6 gene has attracted intense research interest due to its apparently important role in the development of eyes and the central nervous system (CNS) in many animal groups. Pax6 is also of interest for comparative genomics since it has not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb60bba66c1a0b7c8e88c76a5adc621
https://europepmc.org/articles/PMC2684816/

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Abstract 2953: Anticipating new biochemical mechanisms of resistance to Raf inhibition in Melanoma

Autor: Rajee Antony, Levi A. Garraway, Caroline Emery

Publikováno v: Cancer Research. 72:2953-2953

More than 50% of melanoma's harbor the V600E activating mutation in BRAF, which constitutively activates the Mek/Erk signaling cascade leading to tumor cell proliferation. The BRAF(V600E) mutation predicts responsiveness to RAF inhibitors, which led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db237667e82ad598de0fb43b73d9dfb1
https://doi.org/10.1158/1538-7445.am2012-2953

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