Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rajdeep Benning"'
Publikováno v:
Xenobiotica. 43:432-442
1. The disposition of anagliptin, an orally active, highly selective dipeptidyl peptidase-4 inhibitor, was investigated after a single oral dose of 100 mg/1.92 MBq [(14)C]anagliptin to six healthy men. Almost all the dose (98.2%) was recovered within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88abcd8d53bee59c544c52f1a5e5a2d5
https://doi.org/10.3109/00498254.2012.731618
https://doi.org/10.3109/00498254.2012.731618
Autor:
Wrona Wojciech, Deborah J. Davis, Hayley Angove, Christopher Thomas Brain, Alison Jo-Anne Woolford, Fan Yang, Kim Lewry, Hong Cheng, Steven Kovats, Chen Christine Hiu-Tung, Alice Loo, Mei Xu, Claudio Dagostin, Miles Congreve, David C. Rees, John William Giraldes, Yaping Wang, Young Shin Cho, Glyn Williams, Rachel McMenamin, Troy Smith, Junqing Shen, Rajiv Chopra, Ruth Feltell, Yipin Lu, Wiesia Maniara, Bharat Lagu, Steven Howard, Kristy Chung, Robert Cheng, Steven Douglas Hiscock, Sunkyu Kim, Luzzio Michael, Marc O'Reilly, Rajdeep Benning, Paul N. Mortenson
Publikováno v:
ACS Medicinal Chemistry Letters. 3:445-449
Herein, we describe the discovery of potent and highly selective inhibitors of both CDK4 and CDK6 via structure-guided optimization of a fragment-based screening hit. CDK6 X-ray crystallography and pharmacokinetic data steered efforts in identifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246f4930f1dba54c810db018516d6ce6
https://doi.org/10.1021/ml200241a
https://doi.org/10.1021/ml200241a
Autor:
Martyn Frederickson, Christopher W. Murray, Neil T. Thompson, Tim Perera, Anne Cleasby, Eddy Jean Edgard Freyne, Ruth Feltell, Jose Cosme, Lynsey Fazal, Christopher Charles Frederick Hamlett, Michael Reader, Rajdeep Benning, Alistair O'Brien, Peter King, Darcey Miller, Matthew Squires, Patrick Angibaud, Andrew Madin, Valerio Berdini, Emma Vickerstaffe, Gordon Saxty, Brent Graham, Charlotte Griffiths Jones, Andrew Pike, Edward J. Lewis, Michael A. Batey, Douglas D. Ross, Susanne S. Bethell, Sharna J. Rich, Lindsay A. Devine, Maria Grazia Carr, Abarna Thiru, Julie Irving, George Ward, John Lyons, David R. Newell
Publikováno v:
Molecular Cancer Therapeutics. 10:1542-1552
We describe here the identification and characterization of 2 novel inhibitors of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases. The compounds exhibit selective inhibition of FGFR over the closely related VEGFR2 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c0b2d868f3d5291f40d90f96003120
https://doi.org/10.1158/1535-7163.mct-11-0426
https://doi.org/10.1158/1535-7163.mct-11-0426