Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Rajat M. Gupta"'
Autor:
Qiuyu Martin Zhu, Yu-Han H. Hsu, Frederik H. Lassen, Bryan T. MacDonald, Stephanie Stead, Edyta Malolepsza, April Kim, Taibo Li, Taiji Mizoguchi, Monica Schenone, Gaelen Guzman, Benjamin Tanenbaum, Nadine Fornelos, Steven A. Carr, Rajat M. Gupta, Patrick T. Ellinor, Kasper Lage
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Population-based association studies have identified many genetic risk loci for coronary artery disease (CAD), but it is often unclear how genes within these loci are linked to CAD. Here, we perform interaction proteomics for 11 CAD-risk gen
Externí odkaz:
https://doaj.org/article/33f24fe85b5e427da89e1cdd0af7dd9f
Autor:
J. Travis Hinson, Anant Chopra, Andre Lowe, Calvin C. Sheng, Rajat M. Gupta, Rajarajan Kuppusamy, John O'Sullivan, Glenn Rowe, Hiroko Wakimoto, Joshua Gorham, Kehan Zhang, Kiran Musunuru, Robert E. Gerszten, Sean M. Wu, Christopher S. Chen, Jonathan G. Seidman, Christine E. Seidman
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3292-3304 (2016)
AMP-activated protein kinase (AMPK) is a metabolic enzyme that can be activated by nutrient stress or genetic mutations. Missense mutations in the regulatory subunit, PRKAG2, activate AMPK and cause left ventricular hypertrophy, glycogen accumulation
Externí odkaz:
https://doaj.org/article/8a8d917c3fe94409bb77320752abdbde
Autor:
J. Travis Hinson, Anant Chopra, Andre Lowe, Calvin C. Sheng, Rajat M. Gupta, Rajarajan Kuppusamy, John O’Sullivan, Glenn Rowe, Hiroko Wakimoto, Joshua Gorham, Michael A. Burke, Kehan Zhang, Kiran Musunuru, Robert E. Gerszten, Sean M. Wu, Christopher S. Chen, Jonathan G. Seidman, Christine E. Seidman
Publikováno v:
Cell Reports, Vol 19, Iss 11, p 2410 (2017)
Externí odkaz:
https://doaj.org/article/a55d9725f02a4a78971d08e8db75c07c
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:600-608
Endothelial cells (EC) are an important mediator of atherosclerosis and vascular disease. Their exposure to atherogenic risk factors such as hypertension and serum cholesterol leads to endothelial dysfunction and many disease-associated processes. Id
Autor:
Michael C. Honigberg, Buu Truong, Raiyan R. Khan, Brenda Xiao, Laxmi Bhatta, Ha My T. Vy, Rafael F. Guerrero, Art Schuermans, Margaret Sunitha Selvaraj, Aniruddh P. Patel, Satoshi Koyama, So Mi Jemma Cho, Shamsudheen Karuthedath Vellarikkal, Mark Trinder, Sarah M. Urbut, Kathryn J. Gray, Ben M. Brumpton, Snehal Patil, Sebastian Zöllner, Mariah C. Antopia, Richa Saxena, Girish N. Nadkarni, Ron Do, Qi Yan, Itsik Pe’er, Shefali Setia Verma, Rajat M. Gupta, David M. Haas, Hilary C. Martin, David A. van Heel, Triin Laisk, Pradeep Natarajan
Publikováno v:
Nature Medicine.
Autor:
Rajat M, Gupta
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 42(5)
Autor:
Aleksandrina Goeva, Michael-John Dolan, Judy Luu, Eric Garcia, Rebecca Boiarsky, Rajat M Gupta, Evan Macosko
In case-control single-cell RNA-seq studies, sample-level labels are transferred onto individual cells, labeling all case cells as affected, but only a small fraction of them may actually be perturbed. Here, using simulations, we demonstrate that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5738aef20b3a1e2e050006be92a07d0a
https://doi.org/10.1101/2023.01.06.523013
https://doi.org/10.1101/2023.01.06.523013
Autor:
Gavin R. Schnitzler, Helen Kang, Vivian S. Lee-Kim, X. Rosa Ma, Tony Zeng, Ramcharan S. Angom, Shi Fang, Shamsudheen Karuthedath Vellarikkal, Ronghao Zhou, Katherine Guo, Oscar Sias-Garcia, Alex Bloemendal, Glen Munson, Philine Guckelberger, Tung H. Nguyen, Drew T. Bergman, Nathan Cheng, Brian Cleary, Krishna Aragam, Debabrata Mukhopadhyay, Eric S. Lander, Hilary K. Finucane, Rajat M. Gupta, Jesse M. Engreitz
Genome-wide association studies (GWAS) have discovered thousands of risk loci for common, complex diseases, each of which could point to genes and gene programs that influence disease. For some diseases, it has been observed that GWAS signals converg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68bba175f1157fd63e5f5dccdcf1c6d9
https://doi.org/10.1101/2022.11.01.514606
https://doi.org/10.1101/2022.11.01.514606
Autor:
Rajat M. Gupta
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42:610-612
Autor:
Dafeng Yang, Stefan Haemmig, Jingshu Chen, Michael McCoy, Henry S. Cheng, Haoyang Zhou, Daniel Pérez-Cremades, Xiao Cheng, Xinghui Sun, Jorge Haneo-Mejia, Shamsudheen K. Vellarikkal, Rajat M. Gupta, Victor Barrera, Mark W. Feinberg
Publikováno v:
Atherosclerosis
BACKGROUND AND AIMS: Chronic vascular endothelial inflammation predisposes to atherosclerosis; however, the cell-autonomous roles for endothelial-expressing microRNAs (miRNAs) are poorly understood in this process. MiR-181b is expressed in several ce